Chrysin, a natural flavone, improves murine inflammatory bowel diseases
- Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, 39 Hallymdaehakgil, Chuncheon, GangwonDo 200-702 (Korea, Republic of)
Chrysin (5,7-dihydroxyflavone) is a natural flavone commonly found in many plants. It has previously been shown to be an anti-tumor agent. In this study, we investigated whether chrysin could alleviate the symptoms of dextran sodium sulfate (DSS)-induced colitis in mice and whether chrysin has an inhibitory effect on nuclear factor (NF)-{kappa}B activation in vitro. A significant blunting of weight loss and clinical signs was observed in DSS-exposed, chrysin-treated mice when compared to vehicle-treated mice. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E{sub 2}, and pro-inflammatory cytokines. In addition, chrysin inhibited tumor necrosis factor (TNF)-{alpha}-induced activation of NF-{kappa}B in IEC-6 cells. These findings suggest that chrysin exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of NF-{kappa}B activation.
- OSTI ID:
- 22199649
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 381, Issue 4; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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