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Title: Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China

Abstract

Strontium has been widely used in industries like electronic and pharmacy. It has a carcinogenic potential, however, and no study has been conducted to evaluate its effects on cancer risk. The aim of this study was to explore the possible association between strontium and breast cancer risk in a case-control study including 240 incident invasive breast cancer patients and 246 age-matched controls. We measured the urinary concentrations of strontium by inductively coupled plasma mass spectrometry, and conducted face-to-face interviews to obtain information on potential breast cancer risk factors. Multivariable analysis was used to estimate the association. Creatinine-adjusted levels [median (25th, 75th) {mu}g/g] of strontium were 155.59 (99.05, 230.70) in the breast cancer patients and 119.62 (81.97, 163.76) in the controls. Women in the highest tertile of strontium showed 124% increased risk of breast cancer, when compared with those in the lowest tertile after adjustment for the potential risk factors [OR (95% CI): 2.24 (1.42-3.81)]. This association was particularly strong for HER2 positive breast cancer [OR (95% CI): 10.92 (3.53-33.77)], and only occurred among premenopausal women. These results suggest a potential role of strontium in the development of breast cancer and urge further studies on the environmental contamination and the physiologicalmore » and pathological mechanisms of strontium.« less

Authors:
 [1];  [1];  [2];  [1];  [2]; ; ;  [1];  [3];  [4];  [1];  [5];  [1]
  1. The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)
  2. (China)
  3. The Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300 (China)
  4. The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080 (China)
  5. The Second Affiliated Hospital, Sun Yat-sen University, 107 Yanjiang West, Guangzhou 510120 (China)
Publication Date:
OSTI Identifier:
22156254
Resource Type:
Journal Article
Journal Name:
Environmental Research
Additional Journal Information:
Journal Volume: 112; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 54 ENVIRONMENTAL SCIENCES; CREATININE; HEALTH HAZARDS; ICP MASS SPECTROSCOPY; MAMMARY GLANDS; NEOPLASMS; PATIENTS; STRONTIUM; URINE

Citation Formats

Chen, Li-Juan, Tang, Lu-Ying, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, He, Jian-Rong, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Su, Yi, Cen, Yu-Ling, Yu, Dan-Dan, Wu, Bang-Hua, Lin, Ying, Chen, Wei-Qing, Song, Er-Wei, E-mail: songerwei02@yahoo.com.cn, and Ren, Ze-Fang, E-mail: renzef@mail.sysu.edu.cn. Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China. United States: N. p., 2012. Web. doi:10.1016/J.ENVRES.2011.11.005.
Chen, Li-Juan, Tang, Lu-Ying, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, He, Jian-Rong, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Su, Yi, Cen, Yu-Ling, Yu, Dan-Dan, Wu, Bang-Hua, Lin, Ying, Chen, Wei-Qing, Song, Er-Wei, E-mail: songerwei02@yahoo.com.cn, & Ren, Ze-Fang, E-mail: renzef@mail.sysu.edu.cn. Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China. United States. doi:10.1016/J.ENVRES.2011.11.005.
Chen, Li-Juan, Tang, Lu-Ying, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, He, Jian-Rong, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Su, Yi, Cen, Yu-Ling, Yu, Dan-Dan, Wu, Bang-Hua, Lin, Ying, Chen, Wei-Qing, Song, Er-Wei, E-mail: songerwei02@yahoo.com.cn, and Ren, Ze-Fang, E-mail: renzef@mail.sysu.edu.cn. Sun . "Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China". United States. doi:10.1016/J.ENVRES.2011.11.005.
@article{osti_22156254,
title = {Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China},
author = {Chen, Li-Juan and Tang, Lu-Ying and The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630 and He, Jian-Rong and Guangzhou Women and Children's Medical Center, Guangzhou 510623 and Su, Yi and Cen, Yu-Ling and Yu, Dan-Dan and Wu, Bang-Hua and Lin, Ying and Chen, Wei-Qing and Song, Er-Wei, E-mail: songerwei02@yahoo.com.cn and Ren, Ze-Fang, E-mail: renzef@mail.sysu.edu.cn},
abstractNote = {Strontium has been widely used in industries like electronic and pharmacy. It has a carcinogenic potential, however, and no study has been conducted to evaluate its effects on cancer risk. The aim of this study was to explore the possible association between strontium and breast cancer risk in a case-control study including 240 incident invasive breast cancer patients and 246 age-matched controls. We measured the urinary concentrations of strontium by inductively coupled plasma mass spectrometry, and conducted face-to-face interviews to obtain information on potential breast cancer risk factors. Multivariable analysis was used to estimate the association. Creatinine-adjusted levels [median (25th, 75th) {mu}g/g] of strontium were 155.59 (99.05, 230.70) in the breast cancer patients and 119.62 (81.97, 163.76) in the controls. Women in the highest tertile of strontium showed 124% increased risk of breast cancer, when compared with those in the lowest tertile after adjustment for the potential risk factors [OR (95% CI): 2.24 (1.42-3.81)]. This association was particularly strong for HER2 positive breast cancer [OR (95% CI): 10.92 (3.53-33.77)], and only occurred among premenopausal women. These results suggest a potential role of strontium in the development of breast cancer and urge further studies on the environmental contamination and the physiological and pathological mechanisms of strontium.},
doi = {10.1016/J.ENVRES.2011.11.005},
journal = {Environmental Research},
issn = {0013-9351},
number = ,
volume = 112,
place = {United States},
year = {2012},
month = {1}
}