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Title: Statistical Modeling of the Eye for Multimodal Treatment Planning for External Beam Radiation Therapy of Intraocular Tumors

Abstract

Purpose: Ocular anatomy and radiation-associated toxicities provide unique challenges for external beam radiation therapy. For treatment planning, precise modeling of organs at risk and tumor volume are crucial. Development of a precise eye model and automatic adaptation of this model to patients' anatomy remain problematic because of organ shape variability. This work introduces the application of a 3-dimensional (3D) statistical shape model as a novel method for precise eye modeling for external beam radiation therapy of intraocular tumors. Methods and Materials: Manual and automatic segmentations were compared for 17 patients, based on head computed tomography (CT) volume scans. A 3D statistical shape model of the cornea, lens, and sclera as well as of the optic disc position was developed. Furthermore, an active shape model was built to enable automatic fitting of the eye model to CT slice stacks. Cross-validation was performed based on leave-one-out tests for all training shapes by measuring dice coefficients and mean segmentation errors between automatic segmentation and manual segmentation by an expert. Results: Cross-validation revealed a dice similarity of 95% {+-} 2% for the sclera and cornea and 91% {+-} 2% for the lens. Overall, mean segmentation error was found to be 0.3 {+-} 0.1 mm.more » Average segmentation time was 14 {+-} 2 s on a standard personal computer. Conclusions: Our results show that the solution presented outperforms state-of-the-art methods in terms of accuracy, reliability, and robustness. Moreover, the eye model shape as well as its variability is learned from a training set rather than by making shape assumptions (eg, as with the spherical or elliptical model). Therefore, the model appears to be capable of modeling nonspherically and nonelliptically shaped eyes.« less

Authors:
 [1];  [2];  [3];  [4];  [1];  [3];  [1]
  1. ARTORG Center for Biomedical Engineering Research, University of Bern (Switzerland)
  2. Department of Radiology, University Hospital Center (CHUV) and University of Lausanne (UNIL), Signal Processing Laboratory - LTS5, Ecole Polytechnique Federale de Lausanne (Switzerland)
  3. Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern (Switzerland)
  4. Department of Ophthalmology, University Hospital Zurich (Switzerland)
Publication Date:
OSTI Identifier:
22149654
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 4; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; COMPUTERIZED TOMOGRAPHY; CORNEA; ERRORS; HEALTH HAZARDS; LENSES; NEOPLASMS; PATIENTS; PLANNING; RADIOTHERAPY; RELIABILITY; SIMULATION; TOXICITY; TRAINING; VALIDATION

Citation Formats

Rueegsegger, Michael B., Bach Cuadra, Meritxell, Pica, Alessia, Amstutz, Christoph A., Rudolph, Tobias, Aebersold, Daniel, and Kowal, Jens H., E-mail: jens.kowal@artorg.unibe.ch. Statistical Modeling of the Eye for Multimodal Treatment Planning for External Beam Radiation Therapy of Intraocular Tumors. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2012.05.040.
Rueegsegger, Michael B., Bach Cuadra, Meritxell, Pica, Alessia, Amstutz, Christoph A., Rudolph, Tobias, Aebersold, Daniel, & Kowal, Jens H., E-mail: jens.kowal@artorg.unibe.ch. Statistical Modeling of the Eye for Multimodal Treatment Planning for External Beam Radiation Therapy of Intraocular Tumors. United States. doi:10.1016/J.IJROBP.2012.05.040.
Rueegsegger, Michael B., Bach Cuadra, Meritxell, Pica, Alessia, Amstutz, Christoph A., Rudolph, Tobias, Aebersold, Daniel, and Kowal, Jens H., E-mail: jens.kowal@artorg.unibe.ch. Thu . "Statistical Modeling of the Eye for Multimodal Treatment Planning for External Beam Radiation Therapy of Intraocular Tumors". United States. doi:10.1016/J.IJROBP.2012.05.040.
@article{osti_22149654,
title = {Statistical Modeling of the Eye for Multimodal Treatment Planning for External Beam Radiation Therapy of Intraocular Tumors},
author = {Rueegsegger, Michael B. and Bach Cuadra, Meritxell and Pica, Alessia and Amstutz, Christoph A. and Rudolph, Tobias and Aebersold, Daniel and Kowal, Jens H., E-mail: jens.kowal@artorg.unibe.ch},
abstractNote = {Purpose: Ocular anatomy and radiation-associated toxicities provide unique challenges for external beam radiation therapy. For treatment planning, precise modeling of organs at risk and tumor volume are crucial. Development of a precise eye model and automatic adaptation of this model to patients' anatomy remain problematic because of organ shape variability. This work introduces the application of a 3-dimensional (3D) statistical shape model as a novel method for precise eye modeling for external beam radiation therapy of intraocular tumors. Methods and Materials: Manual and automatic segmentations were compared for 17 patients, based on head computed tomography (CT) volume scans. A 3D statistical shape model of the cornea, lens, and sclera as well as of the optic disc position was developed. Furthermore, an active shape model was built to enable automatic fitting of the eye model to CT slice stacks. Cross-validation was performed based on leave-one-out tests for all training shapes by measuring dice coefficients and mean segmentation errors between automatic segmentation and manual segmentation by an expert. Results: Cross-validation revealed a dice similarity of 95% {+-} 2% for the sclera and cornea and 91% {+-} 2% for the lens. Overall, mean segmentation error was found to be 0.3 {+-} 0.1 mm. Average segmentation time was 14 {+-} 2 s on a standard personal computer. Conclusions: Our results show that the solution presented outperforms state-of-the-art methods in terms of accuracy, reliability, and robustness. Moreover, the eye model shape as well as its variability is learned from a training set rather than by making shape assumptions (eg, as with the spherical or elliptical model). Therefore, the model appears to be capable of modeling nonspherically and nonelliptically shaped eyes.},
doi = {10.1016/J.IJROBP.2012.05.040},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}