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Title: Carbon Ion Radiotherapy in Advanced Hypofractionated Regimens for Prostate Cancer: From 20 to 16 Fractions

Abstract

Purpose: To assess the effects of differences in dose fractionation on late radiation toxicity and biochemical control in patients with prostate cancer treated with carbon ion radiotherapy (C-ion RT). Methods and Materials: A total of 740 prostate cancer patients who received C-ion RT between April 2000 and February 2009 were analyzed. Of those, 664 patients followed for at least 1 year were analyzed with regard to late radiation toxicity. Biochemical relapse-free (BRF) and overall survival (OS) rates in patient subgroups with each dose-fractionation were analyzed. Results: Only 1 case of grade 3 genitourinary (GU) morbidity was observed in 20 fractions, and none of the patients developed higher grade morbidities. The incidence of late GU toxicity in patients treated with 16 fractions was lower than that of patients treated with 20 fractions. The OS rate and BRF rate of the entire group at 5 years were 95.2% and 89.7%, respectively. The 5-year BRF rate of the patients treated with 16 fractions of C-ion RT (88.5%) was comparable to that of the patients treated with 20 fractions (90.2%). Conclusion: C-ion RT of 57.6 GyE (the physical C-ion dose [Gy] Multiplication-Sign RBE) in 16 fractions could offer an even lower incidence of genitourinarymore » toxicity and comparable BRF rate than that in 20 fractions. Advancement in hypofractionation could be safely achieved with C-ion RT for prostate cancer.« less

Authors:
 [1];  [1];  [1]; ; ;  [2];  [1]
  1. National Institute of Radiological Sciences, Chiba (Japan)
  2. Department of Urology, Graduate School of Medicine, Chiba University, Chiba (Japan)
Publication Date:
OSTI Identifier:
22149636
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 4; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON IONS; DISEASE INCIDENCE; FRACTIONATED IRRADIATION; NEOPLASMS; PATIENTS; PROSTATE; RADIATION DOSES; RADIOTHERAPY; TOXICITY

Citation Formats

Okada, Tohru, Tsuji, Hiroshi, E-mail: h_tsuji@nirs.go.jp, Kamada, Tadashi, Akakura, Koichiro, Suzuki, Hiroyoshi, Shimazaki, Jun, and Tsujii, Hirohiko. Carbon Ion Radiotherapy in Advanced Hypofractionated Regimens for Prostate Cancer: From 20 to 16 Fractions. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2012.01.072.
Okada, Tohru, Tsuji, Hiroshi, E-mail: h_tsuji@nirs.go.jp, Kamada, Tadashi, Akakura, Koichiro, Suzuki, Hiroyoshi, Shimazaki, Jun, & Tsujii, Hirohiko. Carbon Ion Radiotherapy in Advanced Hypofractionated Regimens for Prostate Cancer: From 20 to 16 Fractions. United States. doi:10.1016/J.IJROBP.2012.01.072.
Okada, Tohru, Tsuji, Hiroshi, E-mail: h_tsuji@nirs.go.jp, Kamada, Tadashi, Akakura, Koichiro, Suzuki, Hiroyoshi, Shimazaki, Jun, and Tsujii, Hirohiko. Thu . "Carbon Ion Radiotherapy in Advanced Hypofractionated Regimens for Prostate Cancer: From 20 to 16 Fractions". United States. doi:10.1016/J.IJROBP.2012.01.072.
@article{osti_22149636,
title = {Carbon Ion Radiotherapy in Advanced Hypofractionated Regimens for Prostate Cancer: From 20 to 16 Fractions},
author = {Okada, Tohru and Tsuji, Hiroshi, E-mail: h_tsuji@nirs.go.jp and Kamada, Tadashi and Akakura, Koichiro and Suzuki, Hiroyoshi and Shimazaki, Jun and Tsujii, Hirohiko},
abstractNote = {Purpose: To assess the effects of differences in dose fractionation on late radiation toxicity and biochemical control in patients with prostate cancer treated with carbon ion radiotherapy (C-ion RT). Methods and Materials: A total of 740 prostate cancer patients who received C-ion RT between April 2000 and February 2009 were analyzed. Of those, 664 patients followed for at least 1 year were analyzed with regard to late radiation toxicity. Biochemical relapse-free (BRF) and overall survival (OS) rates in patient subgroups with each dose-fractionation were analyzed. Results: Only 1 case of grade 3 genitourinary (GU) morbidity was observed in 20 fractions, and none of the patients developed higher grade morbidities. The incidence of late GU toxicity in patients treated with 16 fractions was lower than that of patients treated with 20 fractions. The OS rate and BRF rate of the entire group at 5 years were 95.2% and 89.7%, respectively. The 5-year BRF rate of the patients treated with 16 fractions of C-ion RT (88.5%) was comparable to that of the patients treated with 20 fractions (90.2%). Conclusion: C-ion RT of 57.6 GyE (the physical C-ion dose [Gy] Multiplication-Sign RBE) in 16 fractions could offer an even lower incidence of genitourinary toxicity and comparable BRF rate than that in 20 fractions. Advancement in hypofractionation could be safely achieved with C-ion RT for prostate cancer.},
doi = {10.1016/J.IJROBP.2012.01.072},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}