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Title: Mapping of RBE-Weighted Doses Between HIMAC- and LEM-Based Treatment Planning Systems for Carbon Ion Therapy

Abstract

Purpose: A method was developed to convert clinically prescribed RBE (Relative Biological Effectiveness)-weighted doses from the approach used at the Heavy-Ion Medical Accelerator (HIMAC) at the National Institute of Radiological Science, Chiba, Japan, to the LEM (Local Effect Model)-based TReatment planning for Particles (TRiP98) approach used in the pilot project at the GSI Helmholtzzentrum, Darmstadt, and the Heidelberg Ion-Beam Therapy Center (HIT). Methods and Materials: The proposed conversion method is based on a simulation of the fixed spread-out Bragg peak (SOBP) depth dose profiles as used for the irradiation at HIMAC by LEM/TRiP98 and a recalculation of the resulting RBE-weighted dose distribution. We present data according to the clinical studies conducted at GSI in the past decade (LEM I), as well as data used in current studies (refined LEM version: LEM IV). Results: We found conversion factors (RBE-weighted dose LEM/RBE-weighted dose HIMAC) reaching from 0.4 to 2.0 for prescribed carbon ion doses from 1 to 60 Gy (RBE) for SOBP extensions ranging from 20 to 120 mm according to the HIMAC approach. A conversion factor of 1.0 was found for approximately 5 Gy (RBE). The conversion factor decreases with increasing prescribed dose. Slightly smaller values for the LEM IV-based datamore » set compared with LEM I were found. A significant dependence of the conversion factor from the SOBP width could be observed in particular for LEM IV, whereas the depth dependence was found to be small. Conclusions: For the interpretation and comparison of clinical trials performed at HIMAC and GSI/HIT, it is of extreme importance to consider these conversion factors because according to the various methods to determine the RBE-weighted dose, similar dose values might not necessarily be related to similar clinical outcomes.« less

Authors:
 [1];  [1];  [2];  [2];  [1];  [2];  [1];  [1];  [2];  [1]
  1. Abteilung Biophysik, GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany)
  2. (Germany)
Publication Date:
OSTI Identifier:
22149612
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAGG CURVE; CARBON IONS; CLINICAL TRIALS; DEPTH DOSE DISTRIBUTIONS; HEAVY IONS; ION BEAMS; IRRADIATION; PLANNING; RADIATION DOSES; RADIOTHERAPY; SIMULATION

Citation Formats

Steinstraeter, Olaf, E-mail: o.steinstraeter@gsi.de, Gruen, Rebecca, Institut fuer Medizinische Physik und Strahlenschutz, TH-Mittelhessen, Giessen, Fachbereich Medizin, Philipps-Universitaet Marburg, Marburg, Scholz, Uwe, Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt, Friedrich, Thomas, Durante, Marco, Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt, and Scholz, Michael. Mapping of RBE-Weighted Doses Between HIMAC- and LEM-Based Treatment Planning Systems for Carbon Ion Therapy. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2012.01.038.
Steinstraeter, Olaf, E-mail: o.steinstraeter@gsi.de, Gruen, Rebecca, Institut fuer Medizinische Physik und Strahlenschutz, TH-Mittelhessen, Giessen, Fachbereich Medizin, Philipps-Universitaet Marburg, Marburg, Scholz, Uwe, Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt, Friedrich, Thomas, Durante, Marco, Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt, & Scholz, Michael. Mapping of RBE-Weighted Doses Between HIMAC- and LEM-Based Treatment Planning Systems for Carbon Ion Therapy. United States. doi:10.1016/J.IJROBP.2012.01.038.
Steinstraeter, Olaf, E-mail: o.steinstraeter@gsi.de, Gruen, Rebecca, Institut fuer Medizinische Physik und Strahlenschutz, TH-Mittelhessen, Giessen, Fachbereich Medizin, Philipps-Universitaet Marburg, Marburg, Scholz, Uwe, Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt, Friedrich, Thomas, Durante, Marco, Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt, and Scholz, Michael. Thu . "Mapping of RBE-Weighted Doses Between HIMAC- and LEM-Based Treatment Planning Systems for Carbon Ion Therapy". United States. doi:10.1016/J.IJROBP.2012.01.038.
@article{osti_22149612,
title = {Mapping of RBE-Weighted Doses Between HIMAC- and LEM-Based Treatment Planning Systems for Carbon Ion Therapy},
author = {Steinstraeter, Olaf, E-mail: o.steinstraeter@gsi.de and Gruen, Rebecca and Institut fuer Medizinische Physik und Strahlenschutz, TH-Mittelhessen, Giessen and Fachbereich Medizin, Philipps-Universitaet Marburg, Marburg and Scholz, Uwe and Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt and Friedrich, Thomas and Durante, Marco and Institut fuer Festkoerperphysik, Technische Universitaet Darmstadt, Darmstadt and Scholz, Michael},
abstractNote = {Purpose: A method was developed to convert clinically prescribed RBE (Relative Biological Effectiveness)-weighted doses from the approach used at the Heavy-Ion Medical Accelerator (HIMAC) at the National Institute of Radiological Science, Chiba, Japan, to the LEM (Local Effect Model)-based TReatment planning for Particles (TRiP98) approach used in the pilot project at the GSI Helmholtzzentrum, Darmstadt, and the Heidelberg Ion-Beam Therapy Center (HIT). Methods and Materials: The proposed conversion method is based on a simulation of the fixed spread-out Bragg peak (SOBP) depth dose profiles as used for the irradiation at HIMAC by LEM/TRiP98 and a recalculation of the resulting RBE-weighted dose distribution. We present data according to the clinical studies conducted at GSI in the past decade (LEM I), as well as data used in current studies (refined LEM version: LEM IV). Results: We found conversion factors (RBE-weighted dose LEM/RBE-weighted dose HIMAC) reaching from 0.4 to 2.0 for prescribed carbon ion doses from 1 to 60 Gy (RBE) for SOBP extensions ranging from 20 to 120 mm according to the HIMAC approach. A conversion factor of 1.0 was found for approximately 5 Gy (RBE). The conversion factor decreases with increasing prescribed dose. Slightly smaller values for the LEM IV-based data set compared with LEM I were found. A significant dependence of the conversion factor from the SOBP width could be observed in particular for LEM IV, whereas the depth dependence was found to be small. Conclusions: For the interpretation and comparison of clinical trials performed at HIMAC and GSI/HIT, it is of extreme importance to consider these conversion factors because according to the various methods to determine the RBE-weighted dose, similar dose values might not necessarily be related to similar clinical outcomes.},
doi = {10.1016/J.IJROBP.2012.01.038},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}