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Title: Impact of Different Treatment Approaches on Pregnancy Outcomes in 99 Women Treated for Hodgkin Lymphoma

Abstract

Purpose: The aim of this study was to evaluate the pregnancy outcomes in women with Hodgkin lymphoma (HL) diagnosis, treated between 1972 and 1999 at Department of Radiotherapy and Hematology of University 'Sapienza' of Roma. Methods and Materials: We retrospectively studied 99 female patients that conceived after treatment for HL. Fifty-nine (59%) were treated with chemotherapy and radiotherapy, 32 (32%) with radiotherapy alone as supradiaphragmatic or as infradiaphragmatic and 8 (8%) patients with chemotherapy alone. Results: Ninety-nine patients reported 145 pregnancies. We observed 132 deliveries (2 of them twin births) after a median of 55 months (range, 14-278 months) from the end of therapy. Twelve women (12%) experienced 13 miscarriages after a median of 50 months (range, 13-120) from the end of therapy. We recorded 9/132 (7%) premature births and 3/134 babies (2%) were underweight at the time of birth. We recorded 2 cases of congenital malformations. No statistical differences were recorded when adverse pregnancy outcomes were analyzed with respect to chemotherapy alone, radiotherapy alone, or combined therapy. Conclusions: No significant associations between pregnancy outcomes and therapeutic approaches were found. In particular, the infradiaphragmatic radiotherapy showed no statistical association with miscarriages, premature birth, and low birth weight at term whenmore » compared with other therapeutic approaches.« less

Authors:
 [1];  [1];  [2];  [1]; ; ;  [3]; ; ; ;  [1]
  1. Department of Radiotherapy, University 'Sapienza', Rome (Italy)
  2. Statistics, Probability and Applied Statistics, University 'Sapienza', Rome (Italy)
  3. Department of Hematology, University 'Sapienza', Rome (Italy)
Publication Date:
OSTI Identifier:
22149585
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; COMBINED THERAPY; CONGENITAL MALFORMATIONS; DIAGNOSIS; HEMATOLOGY; LYMPHOMAS; PARTURITION; PATIENTS; PREGNANCY; RADIOTHERAPY; WOMEN

Citation Formats

De Sanctis, Vitaliana, E-mail: vitaliana.desanctis@uniroma1.it, Filippone, Francesco Romeo, Alfo, Marco, Muni, Roberta, Cavalieri, Elena, Pulsoni, Alessandro, Annechini, Giorgia, Valeriani, Maurizio, Osti, Mattia Falchetto, Minniti, Giuseppe, and Enrici, Riccardo Maurizi. Impact of Different Treatment Approaches on Pregnancy Outcomes in 99 Women Treated for Hodgkin Lymphoma. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.12.066.
De Sanctis, Vitaliana, E-mail: vitaliana.desanctis@uniroma1.it, Filippone, Francesco Romeo, Alfo, Marco, Muni, Roberta, Cavalieri, Elena, Pulsoni, Alessandro, Annechini, Giorgia, Valeriani, Maurizio, Osti, Mattia Falchetto, Minniti, Giuseppe, & Enrici, Riccardo Maurizi. Impact of Different Treatment Approaches on Pregnancy Outcomes in 99 Women Treated for Hodgkin Lymphoma. United States. doi:10.1016/J.IJROBP.2011.12.066.
De Sanctis, Vitaliana, E-mail: vitaliana.desanctis@uniroma1.it, Filippone, Francesco Romeo, Alfo, Marco, Muni, Roberta, Cavalieri, Elena, Pulsoni, Alessandro, Annechini, Giorgia, Valeriani, Maurizio, Osti, Mattia Falchetto, Minniti, Giuseppe, and Enrici, Riccardo Maurizi. Thu . "Impact of Different Treatment Approaches on Pregnancy Outcomes in 99 Women Treated for Hodgkin Lymphoma". United States. doi:10.1016/J.IJROBP.2011.12.066.
@article{osti_22149585,
title = {Impact of Different Treatment Approaches on Pregnancy Outcomes in 99 Women Treated for Hodgkin Lymphoma},
author = {De Sanctis, Vitaliana, E-mail: vitaliana.desanctis@uniroma1.it and Filippone, Francesco Romeo and Alfo, Marco and Muni, Roberta and Cavalieri, Elena and Pulsoni, Alessandro and Annechini, Giorgia and Valeriani, Maurizio and Osti, Mattia Falchetto and Minniti, Giuseppe and Enrici, Riccardo Maurizi},
abstractNote = {Purpose: The aim of this study was to evaluate the pregnancy outcomes in women with Hodgkin lymphoma (HL) diagnosis, treated between 1972 and 1999 at Department of Radiotherapy and Hematology of University 'Sapienza' of Roma. Methods and Materials: We retrospectively studied 99 female patients that conceived after treatment for HL. Fifty-nine (59%) were treated with chemotherapy and radiotherapy, 32 (32%) with radiotherapy alone as supradiaphragmatic or as infradiaphragmatic and 8 (8%) patients with chemotherapy alone. Results: Ninety-nine patients reported 145 pregnancies. We observed 132 deliveries (2 of them twin births) after a median of 55 months (range, 14-278 months) from the end of therapy. Twelve women (12%) experienced 13 miscarriages after a median of 50 months (range, 13-120) from the end of therapy. We recorded 9/132 (7%) premature births and 3/134 babies (2%) were underweight at the time of birth. We recorded 2 cases of congenital malformations. No statistical differences were recorded when adverse pregnancy outcomes were analyzed with respect to chemotherapy alone, radiotherapy alone, or combined therapy. Conclusions: No significant associations between pregnancy outcomes and therapeutic approaches were found. In particular, the infradiaphragmatic radiotherapy showed no statistical association with miscarriages, premature birth, and low birth weight at term when compared with other therapeutic approaches.},
doi = {10.1016/J.IJROBP.2011.12.066},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}