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Title: Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer

Abstract

Purpose: The purpose of this study was to examine factors associated with the presence of secondary external and internal lymphedema in patients with head-and-neck cancer (HNC). Methods and Materials: The sample included 81 patients {>=}3 months after HNC treatment. Physical and endoscopic examinations were conducted to determine if participants had external, internal, and/or combined head-and-neck lymphedema. Logistic regression analysis was used to examine the factors associated with the presence of lymphedema. Results: The following factors were statistically significantly associated with presence of lymphedema: (1) location of tumor associated with presence of external (P=.009) and combined lymphedema (P=.032); (2) time since end of HNC treatment associated with presence of external (P=.004) and combined lymphedema (P=.005); (3) total dosage of radiation therapy (P=.010) and days of radiation (P=.017) associated with the presence of combined lymphedema; (4) radiation status of surgical bed was associated with the presence of internal lymphedema, including surgery with postoperative radiation (P=.030) and (salvage) surgery in the irradiated field (P=.008); and (5) number of treatment modalities associated with external (P=.002), internal (P=.039), and combined lymphedema (P=.004). No demographic, health behavior-related, or comorbidity factors were associated with the presence of lymphedema in the sample. Conclusions: Select tumor and treatment parametersmore » are associated with increased occurrence of lymphedema in patients with HNC. Larger and longitudinal studies are needed to identify adjusted effects and causative risk factors contributing to the development of lymphedema in patients with HNC.« less

Authors:
 [1];  [1];  [2];  [1];  [2];  [2]; ;  [1]; ; ;  [3]
  1. School of Nursing, Vanderbilt University, Nashville, Tennessee (United States)
  2. (United States)
  3. Vanderbilt-Ingram Cancer Center, Nashville, Tennessee (United States)
Publication Date:
OSTI Identifier:
22149584
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEAD; HEALTH HAZARDS; NECK; NEOPLASMS; PATIENTS; RADIOTHERAPY; REGRESSION ANALYSIS; SURGERY

Citation Formats

Deng Jie, E-mail: jie.deng@vanderbilt.edu, Ridner, Sheila H., Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, Dietrich, Mary S., Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, Tennessee, Wells, Nancy, Wallston, Kenneth A., Sinard, Robert J., Cmelak, Anthony J., and Murphy, Barbara A. Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2012.04.013.
Deng Jie, E-mail: jie.deng@vanderbilt.edu, Ridner, Sheila H., Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, Dietrich, Mary S., Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, Tennessee, Wells, Nancy, Wallston, Kenneth A., Sinard, Robert J., Cmelak, Anthony J., & Murphy, Barbara A. Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer. United States. doi:10.1016/J.IJROBP.2012.04.013.
Deng Jie, E-mail: jie.deng@vanderbilt.edu, Ridner, Sheila H., Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, Dietrich, Mary S., Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, Tennessee, Wells, Nancy, Wallston, Kenneth A., Sinard, Robert J., Cmelak, Anthony J., and Murphy, Barbara A. Thu . "Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer". United States. doi:10.1016/J.IJROBP.2012.04.013.
@article{osti_22149584,
title = {Factors Associated With External and Internal Lymphedema in Patients With Head-and-Neck Cancer},
author = {Deng Jie, E-mail: jie.deng@vanderbilt.edu and Ridner, Sheila H. and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee and Dietrich, Mary S. and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee and Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, Tennessee and Wells, Nancy and Wallston, Kenneth A. and Sinard, Robert J. and Cmelak, Anthony J. and Murphy, Barbara A.},
abstractNote = {Purpose: The purpose of this study was to examine factors associated with the presence of secondary external and internal lymphedema in patients with head-and-neck cancer (HNC). Methods and Materials: The sample included 81 patients {>=}3 months after HNC treatment. Physical and endoscopic examinations were conducted to determine if participants had external, internal, and/or combined head-and-neck lymphedema. Logistic regression analysis was used to examine the factors associated with the presence of lymphedema. Results: The following factors were statistically significantly associated with presence of lymphedema: (1) location of tumor associated with presence of external (P=.009) and combined lymphedema (P=.032); (2) time since end of HNC treatment associated with presence of external (P=.004) and combined lymphedema (P=.005); (3) total dosage of radiation therapy (P=.010) and days of radiation (P=.017) associated with the presence of combined lymphedema; (4) radiation status of surgical bed was associated with the presence of internal lymphedema, including surgery with postoperative radiation (P=.030) and (salvage) surgery in the irradiated field (P=.008); and (5) number of treatment modalities associated with external (P=.002), internal (P=.039), and combined lymphedema (P=.004). No demographic, health behavior-related, or comorbidity factors were associated with the presence of lymphedema in the sample. Conclusions: Select tumor and treatment parameters are associated with increased occurrence of lymphedema in patients with HNC. Larger and longitudinal studies are needed to identify adjusted effects and causative risk factors contributing to the development of lymphedema in patients with HNC.},
doi = {10.1016/J.IJROBP.2012.04.013},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}