skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

Abstract

Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15-84 years). The range of external-beam radiation delivered was 50.0-75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90-120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7-70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuriamore » was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.« less

Authors:
; ; ; ; ;  [1];  [1]
  1. Department of Radiation Oncology, Drexel University College of Medicine, Philadelphia, Pennsylvania (United States)
Publication Date:
OSTI Identifier:
22149580
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CYSTS; OXYGEN; PATIENTS; PROCTITIS; PROSTATE; RADIATION INJURIES; RADIOTHERAPY; SIDE EFFECTS; SYMPTOMS; TOXICITY

Citation Formats

Oliai, Caspian, Fisher, Brandon, Jani, Ashish, Wong, Michael, Poli, Jaganmohan, Brady, Luther W., and Komarnicky, Lydia T., E-mail: lydia.komarnicky-kocher@drexelmed.edu. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.12.056.
Oliai, Caspian, Fisher, Brandon, Jani, Ashish, Wong, Michael, Poli, Jaganmohan, Brady, Luther W., & Komarnicky, Lydia T., E-mail: lydia.komarnicky-kocher@drexelmed.edu. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis. United States. doi:10.1016/J.IJROBP.2011.12.056.
Oliai, Caspian, Fisher, Brandon, Jani, Ashish, Wong, Michael, Poli, Jaganmohan, Brady, Luther W., and Komarnicky, Lydia T., E-mail: lydia.komarnicky-kocher@drexelmed.edu. Thu . "Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis". United States. doi:10.1016/J.IJROBP.2011.12.056.
@article{osti_22149580,
title = {Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis},
author = {Oliai, Caspian and Fisher, Brandon and Jani, Ashish and Wong, Michael and Poli, Jaganmohan and Brady, Luther W. and Komarnicky, Lydia T., E-mail: lydia.komarnicky-kocher@drexelmed.edu},
abstractNote = {Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15-84 years). The range of external-beam radiation delivered was 50.0-75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90-120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7-70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.},
doi = {10.1016/J.IJROBP.2011.12.056},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}