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Title: Silver Clear Nylon Dressing is Effective in Preventing Radiation-Induced Dermatitis in Patients With Lower Gastrointestinal Cancer: Results From a Phase III Study

Abstract

Purpose: For patients with anal canal and advanced rectal cancer, chemoradiation therapy is a curative modality or an important adjunct to surgery. Nearly all patients treated with chemoradiation experience some degree of radiation-induced dermatitis (RID). Prevention and effective treatment of RID, therefore, is of considerable clinical relevance. The present phase III randomized trial compared the efficacy of silver clear nylon dressing (SCND) with that of standard skin care for these patients. Methods and Materials: A total of 42 rectal or anal canal cancer patients were randomized to either a SCND or standard skin care group. SCND was applied from Day 1 of radiation therapy (RT) until 2 weeks after treatment completion. In the control arm, sulfadiazine cream was applied at the time of skin dermatitis. Printed digital photographs taken 2 weeks prior to, on the last day, and two weeks after the treatment completion were scored by 10 blinded readers, who used the common toxicity scoring system for skin dermatitis. Results: The radiation dose ranged from 50.4 to 59.4 Gy, and there were no differences between the 2 groups. On the last day of RT, when the most severe RID occurs, the mean dermatitis score was 2.53 (standard deviation [SD],more » 1.17) for the standard and 1.67 (SD, 1.2; P=.01) for the SCND arm. At 2 weeks after RT, the difference was 0.39 points in favor of SCND (P=.39). There was considerable intraclass correlation among the 10 observers. Conclusions: Silver clear nylon dressing is effective in reducing RID in patients with lower gastrointestinal cancer treated with combined chemotherapy and radiation treatment.« less

Authors:
 [1];  [1];  [2];  [3];  [4];  [5]; ; ; ;  [6];  [7]
  1. Segal Cancer Centre, Department of Radiation Oncology, Jewish General Hospital, McGill University (Canada)
  2. Department of Epidemiology, Jewish General Hospital, McGill University (Canada)
  3. Department of Clinical Oncology, Leiden University Medical Center, Amsterdam (Netherlands)
  4. Department of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw (Poland)
  5. Department of Radiation Oncology, Hotel-Dieu de France Hospital (Lebanon)
  6. Department of Radiation Oncology, Montreal-General-Hospital, McGill University, Montreal (Canada)
  7. Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto (Canada)
Publication Date:
OSTI Identifier:
22149575
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; DERMATITIS; IMAGES; NEOPLASMS; NYLON; PATIENTS; PHOTOGRAPHY; RADIATION DOSES; RADIOTHERAPY; RECTUM; SILVER; SKIN; STANDARDS; SULFONAMIDES; SURGERY; TOXICITY

Citation Formats

Niazi, Tamim M., Vuong, Te, E-mail: tvuong@jgh.mcgill.ca, Azoulay, Laurant, Marijnen, Corrie, Bujko, Kryzstof, Nasr, Elie, Lambert, Christine, Duclos, Marie, Faria, Sergio, David, Marc, and Cummings, Bernard. Silver Clear Nylon Dressing is Effective in Preventing Radiation-Induced Dermatitis in Patients With Lower Gastrointestinal Cancer: Results From a Phase III Study. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2012.03.062.
Niazi, Tamim M., Vuong, Te, E-mail: tvuong@jgh.mcgill.ca, Azoulay, Laurant, Marijnen, Corrie, Bujko, Kryzstof, Nasr, Elie, Lambert, Christine, Duclos, Marie, Faria, Sergio, David, Marc, & Cummings, Bernard. Silver Clear Nylon Dressing is Effective in Preventing Radiation-Induced Dermatitis in Patients With Lower Gastrointestinal Cancer: Results From a Phase III Study. United States. doi:10.1016/J.IJROBP.2012.03.062.
Niazi, Tamim M., Vuong, Te, E-mail: tvuong@jgh.mcgill.ca, Azoulay, Laurant, Marijnen, Corrie, Bujko, Kryzstof, Nasr, Elie, Lambert, Christine, Duclos, Marie, Faria, Sergio, David, Marc, and Cummings, Bernard. Thu . "Silver Clear Nylon Dressing is Effective in Preventing Radiation-Induced Dermatitis in Patients With Lower Gastrointestinal Cancer: Results From a Phase III Study". United States. doi:10.1016/J.IJROBP.2012.03.062.
@article{osti_22149575,
title = {Silver Clear Nylon Dressing is Effective in Preventing Radiation-Induced Dermatitis in Patients With Lower Gastrointestinal Cancer: Results From a Phase III Study},
author = {Niazi, Tamim M. and Vuong, Te, E-mail: tvuong@jgh.mcgill.ca and Azoulay, Laurant and Marijnen, Corrie and Bujko, Kryzstof and Nasr, Elie and Lambert, Christine and Duclos, Marie and Faria, Sergio and David, Marc and Cummings, Bernard},
abstractNote = {Purpose: For patients with anal canal and advanced rectal cancer, chemoradiation therapy is a curative modality or an important adjunct to surgery. Nearly all patients treated with chemoradiation experience some degree of radiation-induced dermatitis (RID). Prevention and effective treatment of RID, therefore, is of considerable clinical relevance. The present phase III randomized trial compared the efficacy of silver clear nylon dressing (SCND) with that of standard skin care for these patients. Methods and Materials: A total of 42 rectal or anal canal cancer patients were randomized to either a SCND or standard skin care group. SCND was applied from Day 1 of radiation therapy (RT) until 2 weeks after treatment completion. In the control arm, sulfadiazine cream was applied at the time of skin dermatitis. Printed digital photographs taken 2 weeks prior to, on the last day, and two weeks after the treatment completion were scored by 10 blinded readers, who used the common toxicity scoring system for skin dermatitis. Results: The radiation dose ranged from 50.4 to 59.4 Gy, and there were no differences between the 2 groups. On the last day of RT, when the most severe RID occurs, the mean dermatitis score was 2.53 (standard deviation [SD], 1.17) for the standard and 1.67 (SD, 1.2; P=.01) for the SCND arm. At 2 weeks after RT, the difference was 0.39 points in favor of SCND (P=.39). There was considerable intraclass correlation among the 10 observers. Conclusions: Silver clear nylon dressing is effective in reducing RID in patients with lower gastrointestinal cancer treated with combined chemotherapy and radiation treatment.},
doi = {10.1016/J.IJROBP.2012.03.062},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}