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Title: Radiosurgery for Para-IAC Meningiomas: The Effect of Radiation Dose to the Cochlea on Hearing Outcome

Abstract

Purpose: This study was performed to assess the radiosurgical results of meningiomas extending into the internal acoustic canal (para-IAC meningiomas), with a particular focus on the effect of radiation dose to the cochlea on hearing outcome. Methods and Materials: A total of 50 patients who underwent radiosurgery for para-IAC meningiomas between 1998 and 2009, which were followed for 2 years, were enrolled. The mean age was 55.8 years (range, 15-75). The mean tumor volume was 6.1 cm{sup 3} (range, 1.0-19.0), the mean tumor length in the IAC was 6.9 mm (range, 1.3-13.3), and the mean prescribed marginal dose was 13.1 Gy (range, 10-15) at an isodose line of 50%. The mean follow-up duration was 46 months (range, 24-122). Results: Eight (16.0%) patients had nonserviceable hearing at the time of surgery. At the last follow-up, the tumor control rate was 94%; unchanged in 17 patients, decreased in 30 patients, and increased in 3 patients. Among 42 patients with serviceable hearing at the time of radiosurgery, it was preserved in 41 (97.6%) patients at the last follow-up. The maximal and mean radiation doses to the cochleae of these 41 patients were 5.8 Gy {+-} 0.3 (range, 3.1-11.5) and 4.3 Gy {+-} 0.2more » (range, 2.2-7.5), respectively. The maximal dose to the cochlea of the patient who lost hearing after radiosurgery was 4.7 Gy. Conclusions: The radiation dose to the cochlea may have the minimal toxic effect on the hearing outcome in patients who undergo radiosurgery for para-IAC meningiomas.« less

Authors:
 [1];  [2];  [3];  [2];  [1];  [2]; ; ;  [3];  [2];  [1];  [2]; ; ;  [3];  [2];  [1];  [2]; ;  [3] more »;  [2] « less
  1. Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si (Korea, Republic of)
  2. (Korea, Republic of)
  3. Department of Neurosurgery, Seoul National University Hospital, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
22149567
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GY RANGE 10-100; NEOPLASMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SURGERY; TOXICITY

Citation Formats

Kim, Young-Hoon, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Dong Gyu, E-mail: gknife@plaza.snu.ac.kr, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Han, Jung Ho, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Chung, Hyun-Tai, Kim, In Kyung, Song, Sang Woo, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Park, Jeong-Hoon, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Jin Wook, Kim, Yong Hwy, Park, Chul-Kee, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Chae-Yong, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Paek, Sun Ha, Jung, Hee-Won, and Department of Neurosurgery, Seoul National University College of Medicine, Seoul. Radiosurgery for Para-IAC Meningiomas: The Effect of Radiation Dose to the Cochlea on Hearing Outcome. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.12.078.
Kim, Young-Hoon, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Dong Gyu, E-mail: gknife@plaza.snu.ac.kr, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Han, Jung Ho, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Chung, Hyun-Tai, Kim, In Kyung, Song, Sang Woo, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Park, Jeong-Hoon, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Jin Wook, Kim, Yong Hwy, Park, Chul-Kee, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Chae-Yong, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Paek, Sun Ha, Jung, Hee-Won, & Department of Neurosurgery, Seoul National University College of Medicine, Seoul. Radiosurgery for Para-IAC Meningiomas: The Effect of Radiation Dose to the Cochlea on Hearing Outcome. United States. doi:10.1016/J.IJROBP.2011.12.078.
Kim, Young-Hoon, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Dong Gyu, E-mail: gknife@plaza.snu.ac.kr, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Han, Jung Ho, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Chung, Hyun-Tai, Kim, In Kyung, Song, Sang Woo, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Park, Jeong-Hoon, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Jin Wook, Kim, Yong Hwy, Park, Chul-Kee, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Kim, Chae-Yong, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Paek, Sun Ha, Jung, Hee-Won, and Department of Neurosurgery, Seoul National University College of Medicine, Seoul. Thu . "Radiosurgery for Para-IAC Meningiomas: The Effect of Radiation Dose to the Cochlea on Hearing Outcome". United States. doi:10.1016/J.IJROBP.2011.12.078.
@article{osti_22149567,
title = {Radiosurgery for Para-IAC Meningiomas: The Effect of Radiation Dose to the Cochlea on Hearing Outcome},
author = {Kim, Young-Hoon and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Kim, Dong Gyu, E-mail: gknife@plaza.snu.ac.kr and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Han, Jung Ho and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Chung, Hyun-Tai and Kim, In Kyung and Song, Sang Woo and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Park, Jeong-Hoon and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Kim, Jin Wook and Kim, Yong Hwy and Park, Chul-Kee and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Kim, Chae-Yong and Department of Neurosurgery, Seoul National University College of Medicine, Seoul and Paek, Sun Ha and Jung, Hee-Won and Department of Neurosurgery, Seoul National University College of Medicine, Seoul},
abstractNote = {Purpose: This study was performed to assess the radiosurgical results of meningiomas extending into the internal acoustic canal (para-IAC meningiomas), with a particular focus on the effect of radiation dose to the cochlea on hearing outcome. Methods and Materials: A total of 50 patients who underwent radiosurgery for para-IAC meningiomas between 1998 and 2009, which were followed for 2 years, were enrolled. The mean age was 55.8 years (range, 15-75). The mean tumor volume was 6.1 cm{sup 3} (range, 1.0-19.0), the mean tumor length in the IAC was 6.9 mm (range, 1.3-13.3), and the mean prescribed marginal dose was 13.1 Gy (range, 10-15) at an isodose line of 50%. The mean follow-up duration was 46 months (range, 24-122). Results: Eight (16.0%) patients had nonserviceable hearing at the time of surgery. At the last follow-up, the tumor control rate was 94%; unchanged in 17 patients, decreased in 30 patients, and increased in 3 patients. Among 42 patients with serviceable hearing at the time of radiosurgery, it was preserved in 41 (97.6%) patients at the last follow-up. The maximal and mean radiation doses to the cochleae of these 41 patients were 5.8 Gy {+-} 0.3 (range, 3.1-11.5) and 4.3 Gy {+-} 0.2 (range, 2.2-7.5), respectively. The maximal dose to the cochlea of the patient who lost hearing after radiosurgery was 4.7 Gy. Conclusions: The radiation dose to the cochlea may have the minimal toxic effect on the hearing outcome in patients who undergo radiosurgery for para-IAC meningiomas.},
doi = {10.1016/J.IJROBP.2011.12.078},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 84,
place = {United States},
year = {Thu Nov 01 00:00:00 EDT 2012},
month = {Thu Nov 01 00:00:00 EDT 2012}
}