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Title: Impact of Triple-Negative Phenotype on Prognosis of Patients With Breast Cancer Brain Metastases

Abstract

Purpose: To elucidate survival times and identify potential prognostic factors in patients with triple-negative (TN) phenotype who harbored brain metastases arising from breast cancer and who underwent stereotactic radiosurgery (SRS). Methods and Materials: A total of 103 breast cancer patients with brain metastases were treated with SRS and then studied retrospectively. Twenty-four patients (23.3%) were TN. Survival times were estimated using the Kaplan-Meier method, with a log-rank test computing the survival time difference between groups. Univariate and multivariate analyses to predict potential prognostic factors were performed using a Cox proportional hazard regression model. Results: The presence of TN phenotype was associated with worse survival times, including overall survival after the diagnosis of primary breast cancer (43 months vs. 82 months), neurologic survival after the diagnosis of intracranial metastases, and radiosurgical survival after SRS, with median survival times being 13 months vs. 25 months and 6 months vs. 16 months, respectively (p < 0.002 in all three comparisons). On multivariate analysis, radiosurgical survival benefit was associated with non-TN status and lower recursive partitioning analysis class at the initial SRS. Conclusion: The TN phenotype represents a significant adverse prognostic factor with respect to overall survival, neurologic survival, and radiosurgical survival in breastmore » cancer patients with intracranial metastasis. Recursive partitioning analysis class also served as an important and independent prognostic factor.« less

Authors:
 [1];  [2];  [1];  [2];  [1]
  1. Department of Neurosurgery, University of Virginia, Charlottesville, Virginia (United States)
  2. Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia (United States)
Publication Date:
OSTI Identifier:
22149556
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 84; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; DIAGNOSIS; HEALTH HAZARDS; MAMMARY GLANDS; METASTASES; MULTIVARIATE ANALYSIS; NEOPLASMS; PATIENTS; RADIOTHERAPY; SURGERY; SURVIVAL TIME

Citation Formats

Xu Zhiyuan, Schlesinger, David, Toulmin, Sushila, Rich, Tyvin, and Sheehan, Jason, E-mail: jps2f@virginia.edu. Impact of Triple-Negative Phenotype on Prognosis of Patients With Breast Cancer Brain Metastases. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.12.054.
Xu Zhiyuan, Schlesinger, David, Toulmin, Sushila, Rich, Tyvin, & Sheehan, Jason, E-mail: jps2f@virginia.edu. Impact of Triple-Negative Phenotype on Prognosis of Patients With Breast Cancer Brain Metastases. United States. doi:10.1016/J.IJROBP.2011.12.054.
Xu Zhiyuan, Schlesinger, David, Toulmin, Sushila, Rich, Tyvin, and Sheehan, Jason, E-mail: jps2f@virginia.edu. Thu . "Impact of Triple-Negative Phenotype on Prognosis of Patients With Breast Cancer Brain Metastases". United States. doi:10.1016/J.IJROBP.2011.12.054.
@article{osti_22149556,
title = {Impact of Triple-Negative Phenotype on Prognosis of Patients With Breast Cancer Brain Metastases},
author = {Xu Zhiyuan and Schlesinger, David and Toulmin, Sushila and Rich, Tyvin and Sheehan, Jason, E-mail: jps2f@virginia.edu},
abstractNote = {Purpose: To elucidate survival times and identify potential prognostic factors in patients with triple-negative (TN) phenotype who harbored brain metastases arising from breast cancer and who underwent stereotactic radiosurgery (SRS). Methods and Materials: A total of 103 breast cancer patients with brain metastases were treated with SRS and then studied retrospectively. Twenty-four patients (23.3%) were TN. Survival times were estimated using the Kaplan-Meier method, with a log-rank test computing the survival time difference between groups. Univariate and multivariate analyses to predict potential prognostic factors were performed using a Cox proportional hazard regression model. Results: The presence of TN phenotype was associated with worse survival times, including overall survival after the diagnosis of primary breast cancer (43 months vs. 82 months), neurologic survival after the diagnosis of intracranial metastases, and radiosurgical survival after SRS, with median survival times being 13 months vs. 25 months and 6 months vs. 16 months, respectively (p < 0.002 in all three comparisons). On multivariate analysis, radiosurgical survival benefit was associated with non-TN status and lower recursive partitioning analysis class at the initial SRS. Conclusion: The TN phenotype represents a significant adverse prognostic factor with respect to overall survival, neurologic survival, and radiosurgical survival in breast cancer patients with intracranial metastasis. Recursive partitioning analysis class also served as an important and independent prognostic factor.},
doi = {10.1016/J.IJROBP.2011.12.054},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 84,
place = {United States},
year = {2012},
month = {11}
}