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Title: Cosmetic Outcome and Seroma Formation After Breast-Conserving Surgery With Intraoperative Radiation Therapy Boost for Early Breast Cancer

Abstract

Purpose: To evaluate cosmetic outcome and its association with breast wound seroma after breast-conserving surgery (BCS) with targeted intraoperative radiation therapy (tIORT) boost for early breast cancer. Methods and Materials: An analysis of a single-arm prospective study of 55 patients with early breast cancer treated with BCS and tIORT boost followed by conventional whole breast radiation therapy (WBRT) between August 2003 and January 2006 was performed. A seroma was defined as a fluid collection at the primary tumor resection site identified clinically or radiologically. Cosmetic assessments using the European Organization for Research and Treatment of Cancer rating system were performed at baseline before BCS and 30 months after WBRT was completed. Results: Twenty-eight patients (51%) developed a seroma, with 18 patients (33%) requiring at least 1 aspiration. Tumor location was significantly associated with seroma formation (P=.001). Ten of 11 patients with an upper inner quadrant tumor developed a seroma. Excellent or good overall cosmetic outcome at 30 months was observed in 34 patients (62%, 95% confidence interval 53%-80%). Seroma formation was not associated with the overall cosmetic result (P=.54). Conclusion: BCS with tIORT boost followed by WBRT was associated with an acceptable cosmetic outcome. Seroma formation was not significantly associatedmore » with an adverse cosmetic outcome.« less

Authors:
 [1];  [2];  [1];  [3]
  1. Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne (Australia)
  2. Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne (Australia)
  3. (Australia)
Publication Date:
OSTI Identifier:
22149498
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 84; Journal Issue: 2; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FLUIDS; MAMMARY GLANDS; NEOPLASMS; PATIENTS; RADIOTHERAPY; SURGERY; WOUNDS

Citation Formats

Senthi, Sashendra, E-mail: sashasenthi@msn.com, Link, Emma, Chua, Boon H., and University of Melbourne, Melbourne. Cosmetic Outcome and Seroma Formation After Breast-Conserving Surgery With Intraoperative Radiation Therapy Boost for Early Breast Cancer. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2012.03.015.
Senthi, Sashendra, E-mail: sashasenthi@msn.com, Link, Emma, Chua, Boon H., & University of Melbourne, Melbourne. Cosmetic Outcome and Seroma Formation After Breast-Conserving Surgery With Intraoperative Radiation Therapy Boost for Early Breast Cancer. United States. doi:10.1016/J.IJROBP.2012.03.015.
Senthi, Sashendra, E-mail: sashasenthi@msn.com, Link, Emma, Chua, Boon H., and University of Melbourne, Melbourne. Mon . "Cosmetic Outcome and Seroma Formation After Breast-Conserving Surgery With Intraoperative Radiation Therapy Boost for Early Breast Cancer". United States. doi:10.1016/J.IJROBP.2012.03.015.
@article{osti_22149498,
title = {Cosmetic Outcome and Seroma Formation After Breast-Conserving Surgery With Intraoperative Radiation Therapy Boost for Early Breast Cancer},
author = {Senthi, Sashendra, E-mail: sashasenthi@msn.com and Link, Emma and Chua, Boon H. and University of Melbourne, Melbourne},
abstractNote = {Purpose: To evaluate cosmetic outcome and its association with breast wound seroma after breast-conserving surgery (BCS) with targeted intraoperative radiation therapy (tIORT) boost for early breast cancer. Methods and Materials: An analysis of a single-arm prospective study of 55 patients with early breast cancer treated with BCS and tIORT boost followed by conventional whole breast radiation therapy (WBRT) between August 2003 and January 2006 was performed. A seroma was defined as a fluid collection at the primary tumor resection site identified clinically or radiologically. Cosmetic assessments using the European Organization for Research and Treatment of Cancer rating system were performed at baseline before BCS and 30 months after WBRT was completed. Results: Twenty-eight patients (51%) developed a seroma, with 18 patients (33%) requiring at least 1 aspiration. Tumor location was significantly associated with seroma formation (P=.001). Ten of 11 patients with an upper inner quadrant tumor developed a seroma. Excellent or good overall cosmetic outcome at 30 months was observed in 34 patients (62%, 95% confidence interval 53%-80%). Seroma formation was not associated with the overall cosmetic result (P=.54). Conclusion: BCS with tIORT boost followed by WBRT was associated with an acceptable cosmetic outcome. Seroma formation was not significantly associated with an adverse cosmetic outcome.},
doi = {10.1016/J.IJROBP.2012.03.015},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 84,
place = {United States},
year = {Mon Oct 01 00:00:00 EDT 2012},
month = {Mon Oct 01 00:00:00 EDT 2012}
}