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Title: Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey

Abstract

Background: Limited epidemiologic data are available concerning the cardiovascular effects of cadmium exposure, although recent studies suggest associations with myocardial infarction and peripheral arterial disease. We examined the associations of cadmium exposure with cardiovascular disease in nationally representative general Korean adults. Methods: We used cross-sectional data on blood cadmium and self-reported diagnoses of ischemic heart disease (IHD), stroke, and hypertension in a sub-sample of 1908 adults, aged 20 years and older, who participated in the 2005 Korea National Health and Nutrition Examination Survey (KNHANES). We used survey logistic regression models accounting for the complex sampling design to estimate the odds ratios (OR), adjusting for age, education, income, alcohol, smoking, body mass index, waist circumference, family history of hypertension, blood pressure, and blood lead. Results: The geometric mean of blood cadmium was 1.53 {mu}g/L. After adjusting for potential confounders, an interquartile range (IQR) increase in blood cadmium (0.91 {mu}g/L) was found to be associated with an increased risk for IHD (OR 2.1, 95% confidence interval (CI) 1.3-3.4). An IQR increase in blood cadmium was found to be associated with an elevated risk for hypertension only among men (OR 1.4, 95% CI 1.1-1.8) but not among women. No association was observed withmore » stroke in both genders. Conclusions: These findings suggest that cadmium in blood may be associated with an increased risk for IHD and hypertension in the general Korean adult population.« less

Authors:
 [1]; ;  [2];  [3]
  1. Department of Environmental Health, Harvard School of Public Health, Boston, MA (United States)
  2. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI (United States)
  3. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI (United States)
Publication Date:
OSTI Identifier:
22149235
Resource Type:
Journal Article
Journal Name:
Environmental Research
Additional Journal Information:
Journal Volume: 111; Journal Issue: 1; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BLOOD; CADMIUM; HYPERTENSION; MYOCARDIAL INFARCTION; NUTRITION; PUBLIC HEALTH

Citation Formats

Lee, Mi-Sun, Park, Sung Kyun, Hu, Howard, Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, Lee, Sundong, and Department of Preventive Medicine, School of Oriental Medicine, Sangji University, Wonju, Kangwon. Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. United States: N. p., 2011. Web. doi:10.1016/J.ENVRES.2010.10.006.
Lee, Mi-Sun, Park, Sung Kyun, Hu, Howard, Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, Lee, Sundong, & Department of Preventive Medicine, School of Oriental Medicine, Sangji University, Wonju, Kangwon. Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. United States. doi:10.1016/J.ENVRES.2010.10.006.
Lee, Mi-Sun, Park, Sung Kyun, Hu, Howard, Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, Lee, Sundong, and Department of Preventive Medicine, School of Oriental Medicine, Sangji University, Wonju, Kangwon. Sat . "Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey". United States. doi:10.1016/J.ENVRES.2010.10.006.
@article{osti_22149235,
title = {Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey},
author = {Lee, Mi-Sun and Park, Sung Kyun and Hu, Howard and Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI and Lee, Sundong and Department of Preventive Medicine, School of Oriental Medicine, Sangji University, Wonju, Kangwon},
abstractNote = {Background: Limited epidemiologic data are available concerning the cardiovascular effects of cadmium exposure, although recent studies suggest associations with myocardial infarction and peripheral arterial disease. We examined the associations of cadmium exposure with cardiovascular disease in nationally representative general Korean adults. Methods: We used cross-sectional data on blood cadmium and self-reported diagnoses of ischemic heart disease (IHD), stroke, and hypertension in a sub-sample of 1908 adults, aged 20 years and older, who participated in the 2005 Korea National Health and Nutrition Examination Survey (KNHANES). We used survey logistic regression models accounting for the complex sampling design to estimate the odds ratios (OR), adjusting for age, education, income, alcohol, smoking, body mass index, waist circumference, family history of hypertension, blood pressure, and blood lead. Results: The geometric mean of blood cadmium was 1.53 {mu}g/L. After adjusting for potential confounders, an interquartile range (IQR) increase in blood cadmium (0.91 {mu}g/L) was found to be associated with an increased risk for IHD (OR 2.1, 95% confidence interval (CI) 1.3-3.4). An IQR increase in blood cadmium was found to be associated with an elevated risk for hypertension only among men (OR 1.4, 95% CI 1.1-1.8) but not among women. No association was observed with stroke in both genders. Conclusions: These findings suggest that cadmium in blood may be associated with an increased risk for IHD and hypertension in the general Korean adult population.},
doi = {10.1016/J.ENVRES.2010.10.006},
journal = {Environmental Research},
issn = {0013-9351},
number = 1,
volume = 111,
place = {United States},
year = {2011},
month = {1}
}