A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age
- Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA (United States)
- Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY (United States)
- Department of Environmental Medicine, Slovak Medical University, Bratislava (Slovakia)
- Department of Immunology and Immunotoxicology, Slovak Medical University, Bratislava (Slovakia)
- Department of Toxic Organic Pollutants, Slovak Medical University, Bratislava (Slovakia)
- Department of Public Health Sciences, University of California, Davis, CA (United States)
- Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA (United States)
Background: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. Methods: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Results: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. Conclusions: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age.
- OSTI ID:
- 22149217
- Journal Information:
- Environmental Research, Vol. 110, Issue 4; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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