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Title: A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties

Abstract

The magnetic-luminescent multifunctional nanoparticles based on Gd-DTPA and NaYF{sub 4}:Yb, Er were successfully synthesized by the conjugation of activated DTPA and silica-coated/surface-aminolated NaYF{sub 4}:Yb, Er nanoparticles through EDC/NHS coupling chemistry. The as-prepared products were characterized by powder X-ray diffraction, transmission electron microscopy, dynamic light scattering, energy dispersive X-ray analysis, and fourier transform infrared spectrometry. The room-temperature upconversion luminescent spectra and T{sub 1}-weighted maps of the obtained nanoparticles were carried out by 980 nm NIR light excitation and a 3T MR imaging scanner, respectively. The results indicated that the as-synthesized multifunctional nanoparticles with small size, highly solubility in water, and both high MR relaxivities and upconversion luminescence may have potential usage for MR imaging in future. - Graphical abstract: We have synthesized magnetic-luminescent multifunctional nanoparticles based on Gd-DTPA and NaYF4:Yb, Er by the conjugation of activated DTPA and silica-coated/surface-aminolated NaYF4:Yb, Er nanoparticles through EDC/NHS coupling chemistry. Highlights: Black-Right-Pointing-Pointer A novel magnetic-luminescent multifunctional nanoparticles are synthesized. Black-Right-Pointing-Pointer The nanoparticles are highly efficient for luminescence and T{sub 1}-weighted MR imaging. Black-Right-Pointing-Pointer The nanoparticles are small in size and highly solubility in water. Black-Right-Pointing-Pointer The nanoparticles hold great potential usage for future biomedical engineering.

Authors:
 [1];  [2];  [1];  [1];  [2]
  1. Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai 200127 (China)
  2. National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Rd, Shanghai 200241 (China)
Publication Date:
OSTI Identifier:
22131103
Resource Type:
Journal Article
Journal Name:
Journal of Solid State Chemistry
Additional Journal Information:
Journal Volume: 192; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0022-4596
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY; DOPED MATERIALS; DTPA; FOURIER TRANSFORMATION; GADOLINIUM COMPOUNDS; LUMINESCENCE; MAGNETIC RESONANCE; NANOSTRUCTURES; PARTICLES; RARE EARTHS; SILICA; TRANSMISSION ELECTRON MICROSCOPY; X RADIATION; X-RAY DIFFRACTION

Citation Formats

Lu Qing, Wei Daixu, Cheng Jiejun, Xu Jianrong, E-mail: xujianr@hotmail.com, and Zhu Jun, E-mail: yzjzhu@163.com. A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties. United States: N. p., 2012. Web. doi:10.1016/J.JSSC.2012.03.016.
Lu Qing, Wei Daixu, Cheng Jiejun, Xu Jianrong, E-mail: xujianr@hotmail.com, & Zhu Jun, E-mail: yzjzhu@163.com. A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties. United States. doi:10.1016/J.JSSC.2012.03.016.
Lu Qing, Wei Daixu, Cheng Jiejun, Xu Jianrong, E-mail: xujianr@hotmail.com, and Zhu Jun, E-mail: yzjzhu@163.com. Wed . "A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties". United States. doi:10.1016/J.JSSC.2012.03.016.
@article{osti_22131103,
title = {A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties},
author = {Lu Qing and Wei Daixu and Cheng Jiejun and Xu Jianrong, E-mail: xujianr@hotmail.com and Zhu Jun, E-mail: yzjzhu@163.com},
abstractNote = {The magnetic-luminescent multifunctional nanoparticles based on Gd-DTPA and NaYF{sub 4}:Yb, Er were successfully synthesized by the conjugation of activated DTPA and silica-coated/surface-aminolated NaYF{sub 4}:Yb, Er nanoparticles through EDC/NHS coupling chemistry. The as-prepared products were characterized by powder X-ray diffraction, transmission electron microscopy, dynamic light scattering, energy dispersive X-ray analysis, and fourier transform infrared spectrometry. The room-temperature upconversion luminescent spectra and T{sub 1}-weighted maps of the obtained nanoparticles were carried out by 980 nm NIR light excitation and a 3T MR imaging scanner, respectively. The results indicated that the as-synthesized multifunctional nanoparticles with small size, highly solubility in water, and both high MR relaxivities and upconversion luminescence may have potential usage for MR imaging in future. - Graphical abstract: We have synthesized magnetic-luminescent multifunctional nanoparticles based on Gd-DTPA and NaYF4:Yb, Er by the conjugation of activated DTPA and silica-coated/surface-aminolated NaYF4:Yb, Er nanoparticles through EDC/NHS coupling chemistry. Highlights: Black-Right-Pointing-Pointer A novel magnetic-luminescent multifunctional nanoparticles are synthesized. Black-Right-Pointing-Pointer The nanoparticles are highly efficient for luminescence and T{sub 1}-weighted MR imaging. Black-Right-Pointing-Pointer The nanoparticles are small in size and highly solubility in water. Black-Right-Pointing-Pointer The nanoparticles hold great potential usage for future biomedical engineering.},
doi = {10.1016/J.JSSC.2012.03.016},
journal = {Journal of Solid State Chemistry},
issn = {0022-4596},
number = ,
volume = 192,
place = {United States},
year = {2012},
month = {8}
}