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Title: Dependences of mucosal dose on photon beams in head-and-neck intensity-modulated radiation therapy: a Monte Carlo study

Abstract

Dependences of mucosal dose in the oral or nasal cavity on the beam energy, beam angle, multibeam configuration, and mucosal thickness were studied for small photon fields using Monte Carlo simulations (EGSnrc-based code), which were validated by measurements. Cylindrical mucosa phantoms (mucosal thickness = 1, 2, and 3 mm) with and without the bone and air inhomogeneities were irradiated by the 6- and 18-MV photon beams (field size = 1 Multiplication-Sign 1 cm{sup 2}) with gantry angles equal to 0 Degree-Sign , 90 Degree-Sign , and 180 Degree-Sign , and multibeam configurations using 2, 4, and 8 photon beams in different orientations around the phantom. Doses along the central beam axis in the mucosal tissue were calculated. The mucosal surface doses were found to decrease slightly (1% for the 6-MV photon beam and 3% for the 18-MV beam) with an increase of mucosal thickness from 1-3 mm, when the beam angle is 0 Degree-Sign . The variation of mucosal surface dose with its thickness became insignificant when the beam angle was changed to 180 Degree-Sign , but the dose at the bone-mucosa interface was found to increase (28% for the 6-MV photon beam and 20% for the 18-MV beam) withmore » the mucosal thickness. For different multibeam configurations, the dependence of mucosal dose on its thickness became insignificant when the number of photon beams around the mucosal tissue was increased. The mucosal dose with bone was varied with the beam energy, beam angle, multibeam configuration and mucosal thickness for a small segmental photon field. These dosimetric variations are important to consider improving the treatment strategy, so the mucosal complications in head-and-neck intensity-modulated radiation therapy can be minimized.« less

Authors:
 [1];  [2];  [2];  [1]
  1. Department of Radiation Physics, Princess Margaret Hospital, Toronto, Ontario (Canada)
  2. (Canada)
Publication Date:
OSTI Identifier:
22130404
Resource Type:
Journal Article
Journal Name:
Medical Dosimetry
Additional Journal Information:
Journal Volume: 37; Journal Issue: 2; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; COMPUTERIZED SIMULATION; DOSIMETRY; MONTE CARLO METHOD; MUCOUS MEMBRANES; NECK; NOSE; PHANTOMS; PHOTON BEAMS; PHOTONS; RADIATION DOSES; RADIOTHERAPY; SKELETON

Citation Formats

Chow, James C.L., E-mail: james.chow@rmp.uhn.on.ca, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Department of Physics, Ryerson University, Toronto, Ontario, and Owrangi, Amir M. Dependences of mucosal dose on photon beams in head-and-neck intensity-modulated radiation therapy: a Monte Carlo study. United States: N. p., 2012. Web. doi:10.1016/J.MEDDOS.2011.07.002.
Chow, James C.L., E-mail: james.chow@rmp.uhn.on.ca, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Department of Physics, Ryerson University, Toronto, Ontario, & Owrangi, Amir M. Dependences of mucosal dose on photon beams in head-and-neck intensity-modulated radiation therapy: a Monte Carlo study. United States. doi:10.1016/J.MEDDOS.2011.07.002.
Chow, James C.L., E-mail: james.chow@rmp.uhn.on.ca, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Department of Physics, Ryerson University, Toronto, Ontario, and Owrangi, Amir M. Sun . "Dependences of mucosal dose on photon beams in head-and-neck intensity-modulated radiation therapy: a Monte Carlo study". United States. doi:10.1016/J.MEDDOS.2011.07.002.
@article{osti_22130404,
title = {Dependences of mucosal dose on photon beams in head-and-neck intensity-modulated radiation therapy: a Monte Carlo study},
author = {Chow, James C.L., E-mail: james.chow@rmp.uhn.on.ca and Department of Radiation Oncology, University of Toronto, Toronto, Ontario and Department of Physics, Ryerson University, Toronto, Ontario and Owrangi, Amir M.},
abstractNote = {Dependences of mucosal dose in the oral or nasal cavity on the beam energy, beam angle, multibeam configuration, and mucosal thickness were studied for small photon fields using Monte Carlo simulations (EGSnrc-based code), which were validated by measurements. Cylindrical mucosa phantoms (mucosal thickness = 1, 2, and 3 mm) with and without the bone and air inhomogeneities were irradiated by the 6- and 18-MV photon beams (field size = 1 Multiplication-Sign 1 cm{sup 2}) with gantry angles equal to 0 Degree-Sign , 90 Degree-Sign , and 180 Degree-Sign , and multibeam configurations using 2, 4, and 8 photon beams in different orientations around the phantom. Doses along the central beam axis in the mucosal tissue were calculated. The mucosal surface doses were found to decrease slightly (1% for the 6-MV photon beam and 3% for the 18-MV beam) with an increase of mucosal thickness from 1-3 mm, when the beam angle is 0 Degree-Sign . The variation of mucosal surface dose with its thickness became insignificant when the beam angle was changed to 180 Degree-Sign , but the dose at the bone-mucosa interface was found to increase (28% for the 6-MV photon beam and 20% for the 18-MV beam) with the mucosal thickness. For different multibeam configurations, the dependence of mucosal dose on its thickness became insignificant when the number of photon beams around the mucosal tissue was increased. The mucosal dose with bone was varied with the beam energy, beam angle, multibeam configuration and mucosal thickness for a small segmental photon field. These dosimetric variations are important to consider improving the treatment strategy, so the mucosal complications in head-and-neck intensity-modulated radiation therapy can be minimized.},
doi = {10.1016/J.MEDDOS.2011.07.002},
journal = {Medical Dosimetry},
issn = {0958-3947},
number = 2,
volume = 37,
place = {United States},
year = {2012},
month = {7}
}