Visceral Blood Flow Modulation: Potential Therapy for Morbid Obesity

Journal Article · Sat Jun 15 00:00:00 EDT 2013 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-013-0560-Z· OSTI ID:22113639

Murphy, Timothy P.; Jay, Bryan S. ^[1]; Hampson, Christopher O.; Zafar, Abdul M. ^[2]

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1. Rhode Island Hospital, Brown University, Department of Diagnostic Imaging, Vascular Disease Research Center (United States)
2. University of Texas Health Science Center at San Antonio, Department of Radiology (United States)

We present this preliminary investigation into the safety and feasibility of endovascular therapy for morbid obesity in a swine model. A flow-limiting, balloon-expandable covered stent was placed in the superior mesenteric artery of three Yorkshire swine after femoral arterial cutdown. The pigs were monitored for between 15 and 51 days after the procedure and then killed, with weights obtained at 2-week increments. In the two pigs in which the stent was flow limiting, a reduced rate of weight gain (0.42 and 0.53 kg/day) was observed relative to the third pig (0.69 kg/day), associated with temporary food aversion and signs of mesenteric ischemia in one pig.

• OSTI ID: 22113639
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 36, Issue 3; Other Information: Copyright (c) 2013 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
ISCHEMIA
METABOLIC DISEASES
SWINE
THERAPY