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Title: Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor

Abstract

The use of lutetium in medicine has been increasing over the last few years. The {sup 177}Lu radionuclide is commercially available for research and test purposes as a diagnostic and radiotherapy agent in the treatment of several malignant tumours. The yield of {sup 177}Lu from the {sup 176}Lu(n,{gamma}){sup 177}Lu nuclear reaction depends significantly on the thermal neutron fluence rate. The capture cross-sections of both reaction {sup 176}Lu(n,{gamma}){sup 177}Lu and reaction {sup 177}Lu(n,{gamma}){sup 178}Lu are very high. Therefore a burn-up of target and product nuclides should be taken into account when calculating {sup 177}Lu activity. The maximum irradiation time, when the activity of the {sup 177}Lu radionuclide begins to decline, was found for different fluence rates. Two vertical irradiation channels at the LVR-15 nuclear research reactor were compared in order to choose the channel with better irradiation conditions, such as a higher thermal neutron fluence rate in the irradiation volume. In this experiment, lutetium was irradiated in a titanium capsule. The influence of the Ti capsule on the neutron spectrum was monitored using activation detectors. The choice of detectors was based on requirements for irradiation time and accurate determination of thermal neutrons. The following activation detectors were selected for measurement ofmore » the neutron spectrum: Ti, Fe, Ni, Co, Ag and W. (authors)« less

Authors:
; ;  [1];  [2]
  1. Research Centre Rez Ltd., Husinec-130, Rez 250 67 (Czech Republic)
  2. Nuclear Physics Inst. of the Academy of Sciences, Husinec-130, Rez 250 67 (Czech Republic)
Publication Date:
Research Org.:
American Nuclear Society, Inc., 555 N. Kensington Avenue, La Grange Park, Illinois 60526 (United States)
OSTI Identifier:
22105862
Resource Type:
Conference
Resource Relation:
Conference: PHYSOR 2012: Conference on Advances in Reactor Physics - Linking Research, Industry, and Education, Knoxville, TN (United States), 15-20 Apr 2012; Other Information: Country of input: France; 5 refs.
Country of Publication:
United States
Language:
English
Subject:
22 GENERAL STUDIES OF NUCLEAR REACTORS; ACTIVATION DETECTORS; BURNUP; CAPSULES; CROSS SECTIONS; EXPERIMENTAL CHANNELS; IRRADIATION; LUTETIUM 176; LUTETIUM 177; LUTETIUM 178; NEUTRON FLUENCE; NEUTRON SPECTRA; NEUTRON SPECTROMETERS; NUCLEAR ENGINEERING; OPTIMIZATION; RADIOTHERAPY; RESEARCH REACTORS; THERMAL NEUTRONS

Citation Formats

Lahodova, Z., Viererbl, L., Klupak, V., and Srank, J. Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor. United States: N. p., 2012. Web.
Lahodova, Z., Viererbl, L., Klupak, V., & Srank, J. Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor. United States.
Lahodova, Z., Viererbl, L., Klupak, V., and Srank, J. Sun . "Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor". United States.
@article{osti_22105862,
title = {Optimization of irradiation conditions for {sup 177}Lu production at the LVR-15 research reactor},
author = {Lahodova, Z. and Viererbl, L. and Klupak, V. and Srank, J.},
abstractNote = {The use of lutetium in medicine has been increasing over the last few years. The {sup 177}Lu radionuclide is commercially available for research and test purposes as a diagnostic and radiotherapy agent in the treatment of several malignant tumours. The yield of {sup 177}Lu from the {sup 176}Lu(n,{gamma}){sup 177}Lu nuclear reaction depends significantly on the thermal neutron fluence rate. The capture cross-sections of both reaction {sup 176}Lu(n,{gamma}){sup 177}Lu and reaction {sup 177}Lu(n,{gamma}){sup 178}Lu are very high. Therefore a burn-up of target and product nuclides should be taken into account when calculating {sup 177}Lu activity. The maximum irradiation time, when the activity of the {sup 177}Lu radionuclide begins to decline, was found for different fluence rates. Two vertical irradiation channels at the LVR-15 nuclear research reactor were compared in order to choose the channel with better irradiation conditions, such as a higher thermal neutron fluence rate in the irradiation volume. In this experiment, lutetium was irradiated in a titanium capsule. The influence of the Ti capsule on the neutron spectrum was monitored using activation detectors. The choice of detectors was based on requirements for irradiation time and accurate determination of thermal neutrons. The following activation detectors were selected for measurement of the neutron spectrum: Ti, Fe, Ni, Co, Ag and W. (authors)},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {7}
}

Conference:
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