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Title: Development of a flexible optical fiber based high resolution integrated PET/MRI system

Abstract

Purpose: The simultaneous measurement of PET and magnetic resonance imaging (MRI) is an emerging field for molecular imaging research. Although optical fiber based PET/MRI systems have advantages on less interference between PET and MRI, there is a drawback in reducing the scintillation light due to the fiber. To reduce the problem, the authors newly developed flexible optical fiber bundle based block detectors and employed them for a high resolution integrated PET/MRI system. Methods: The flexible optical fiber bundle used 0.5 mm diameter, 80 cm long double clad fibers which have dual 12 mm Multiplication-Sign 24 mm rectangular inputs and a single 24 mm Multiplication-Sign 24 mm rectangular output. In the input surface, LGSO scintillators of 0.025 mol.% (decay time: {approx}31 ns: 0.9 mm Multiplication-Sign 1.3 mm Multiplication-Sign 5 mm) and 0.75 mol.% (decay time: {approx}46 ns: 0.9 mm Multiplication-Sign 1.3 mm Multiplication-Sign 6 mm) were optically coupled in depth direction to form depth-of-interaction detector, arranged in 11 Multiplication-Sign 13 matrix and optically coupled to the fiber bundle. The two inputs of the bundle are bent for 90 Degree-Sign , bound to one, and are optically coupled to a Hamamatsu 1-in. square position sensitive photomultiplier tube. Results: Light loss due tomore » the fiber bundle could be reduced and the performance of the block detectors was improved. Eight optical fiber based block detectors (16 LGSO blocks) were arranged in a 56 mm diameter ring to form a PET system. Spatial resolution and sensitivity were 1.2 mm full-width at half-maximum and 1.2% at the central field-of-view, respectively. Sensitivity change was less than 1% for 2 Degree-Sign C temperature changes. This PET system was integrated with a 0.3 T permanent magnet MRI system which has 17 cm diameter hole at the yoke area for insertion of the PET detector ring. There was no observable interference between PET and MRI. Simultaneous imaging of PET and MRI was successfully performed for small animal studies. Conclusions: The authors confirmed that the developed high resolution PET/MRI system is promising for molecular imaging research.« less

Authors:
; ; ; ; ; ; ;  [1];  [2];  [2];  [2];  [2];  [3]
  1. Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673 (Japan)
  2. (Japan)
  3. (Japan) and Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871 (Japan)
Publication Date:
OSTI Identifier:
22099076
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 39; Journal Issue: 11; Other Information: (c) 2012 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 60 APPLIED LIFE SCIENCES; BIOPHYSICS; NMR IMAGING; OPTICAL FIBERS; PERMANENT MAGNETS; POSITRON COMPUTED TOMOGRAPHY; SENSITIVITY; SOLID SCINTILLATION DETECTORS; SPATIAL RESOLUTION

Citation Formats

Yamamoto, Seiichi, Watabe, Hiroshi, Kanai, Yasukazu, Watabe, Tadashi, Aoki, Masaaki, Sugiyama, Eiji, Kato, Katsuhiko, Hatazawa, Jun, Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Neomax Engineering, Takasaki 370-2115, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, and Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka 565-0871. Development of a flexible optical fiber based high resolution integrated PET/MRI system. United States: N. p., 2012. Web. doi:10.1118/1.4757911.
Yamamoto, Seiichi, Watabe, Hiroshi, Kanai, Yasukazu, Watabe, Tadashi, Aoki, Masaaki, Sugiyama, Eiji, Kato, Katsuhiko, Hatazawa, Jun, Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Neomax Engineering, Takasaki 370-2115, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, & Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka 565-0871. Development of a flexible optical fiber based high resolution integrated PET/MRI system. United States. doi:10.1118/1.4757911.
Yamamoto, Seiichi, Watabe, Hiroshi, Kanai, Yasukazu, Watabe, Tadashi, Aoki, Masaaki, Sugiyama, Eiji, Kato, Katsuhiko, Hatazawa, Jun, Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Neomax Engineering, Takasaki 370-2115, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, and Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka 565-0871. Thu . "Development of a flexible optical fiber based high resolution integrated PET/MRI system". United States. doi:10.1118/1.4757911.
@article{osti_22099076,
title = {Development of a flexible optical fiber based high resolution integrated PET/MRI system},
author = {Yamamoto, Seiichi and Watabe, Hiroshi and Kanai, Yasukazu and Watabe, Tadashi and Aoki, Masaaki and Sugiyama, Eiji and Kato, Katsuhiko and Hatazawa, Jun and Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871 and Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 565-0871 Osaka and Neomax Engineering, Takasaki 370-2115 and Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673 and Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka 565-0871},
abstractNote = {Purpose: The simultaneous measurement of PET and magnetic resonance imaging (MRI) is an emerging field for molecular imaging research. Although optical fiber based PET/MRI systems have advantages on less interference between PET and MRI, there is a drawback in reducing the scintillation light due to the fiber. To reduce the problem, the authors newly developed flexible optical fiber bundle based block detectors and employed them for a high resolution integrated PET/MRI system. Methods: The flexible optical fiber bundle used 0.5 mm diameter, 80 cm long double clad fibers which have dual 12 mm Multiplication-Sign 24 mm rectangular inputs and a single 24 mm Multiplication-Sign 24 mm rectangular output. In the input surface, LGSO scintillators of 0.025 mol.% (decay time: {approx}31 ns: 0.9 mm Multiplication-Sign 1.3 mm Multiplication-Sign 5 mm) and 0.75 mol.% (decay time: {approx}46 ns: 0.9 mm Multiplication-Sign 1.3 mm Multiplication-Sign 6 mm) were optically coupled in depth direction to form depth-of-interaction detector, arranged in 11 Multiplication-Sign 13 matrix and optically coupled to the fiber bundle. The two inputs of the bundle are bent for 90 Degree-Sign , bound to one, and are optically coupled to a Hamamatsu 1-in. square position sensitive photomultiplier tube. Results: Light loss due to the fiber bundle could be reduced and the performance of the block detectors was improved. Eight optical fiber based block detectors (16 LGSO blocks) were arranged in a 56 mm diameter ring to form a PET system. Spatial resolution and sensitivity were 1.2 mm full-width at half-maximum and 1.2% at the central field-of-view, respectively. Sensitivity change was less than 1% for 2 Degree-Sign C temperature changes. This PET system was integrated with a 0.3 T permanent magnet MRI system which has 17 cm diameter hole at the yoke area for insertion of the PET detector ring. There was no observable interference between PET and MRI. Simultaneous imaging of PET and MRI was successfully performed for small animal studies. Conclusions: The authors confirmed that the developed high resolution PET/MRI system is promising for molecular imaging research.},
doi = {10.1118/1.4757911},
journal = {Medical Physics},
issn = {0094-2405},
number = 11,
volume = 39,
place = {United States},
year = {2012},
month = {11}
}