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Title: Characterization of an x-ray phase contrast imaging system based on the miniature synchrotron MIRRORCLE-6X

Abstract

Purpose: The implementation of in-line x-ray phase contrast imaging (PCI) for soft-tissue patient imaging is hampered by the lack of a bright and spatially coherent x-ray source that fits into the hospital environment. This article provides a quantitative characterization of the phase-contrast enhancement of a PCI system based on the miniature synchrotron technology MIRRORCLE-6X. Methods: The phase-contrast effect was measured using an edge response of a plexiglass plate as a function of the incident angle of radiation. We have developed a comprehensive x-ray propagation model based on the system's components, properties, and geometry in order to interpret the measurement data. Monte-Carlo simulations are used to estimate the system's spectral properties and resolution. Results: The measured ratio of the detected phase-contrast to the absorption contrast is currently in the range 100% to 200%. Experiments show that with the current implementation of the MIRRORCLE-6X, a target smaller than 30-40 {mu}m does not lead to a larger phase-contrast. The reason for this is that the fraction of x-rays produced by the material (carbon filament and glue) that is used for mounting the target in the electron beam is more than 25% of the total amount of x-rays produced. This increases the apparent sourcemore » size. The measured phase-contrast is at maximum two times larger than the absorption contrast with the current set-up. Conclusions: Calculations based on our model of the present imaging system predict that the phase-contrast can be up to an order of magnitude larger than the absorption contrast in case the materials used for mounting the target in the electron beam do not (or hardly) produce x-rays. The methods described in this paper provide vital feedback for guiding future modifications to the design of the x-ray target of MIRRORCLE-type system and configuration of the in-line PCI systems in general.« less

Authors:
; ; ; ; ; ;  [1];  [2];  [3];  [3];  [3]
  1. Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft (Netherlands)
  2. (Japan)
  3. (Netherlands)
Publication Date:
OSTI Identifier:
22098618
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 38; Journal Issue: 9; Other Information: (c) 2011 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; ABSORPTION; CARBON; COMPUTERIZED SIMULATION; CONFIGURATION; DESIGN; ELECTRON BEAMS; FEEDBACK; FILAMENTS; HOSPITALS; MATERIALS; MODIFICATIONS; MONTE CARLO METHOD; PATIENTS; PLATES; RESOLUTION; SYNCHROTRON RADIATION; X RADIATION; X-RAY SOURCES

Citation Formats

Heekeren, Joop van, Kostenko, Alexander, Hanashima, Takayasu, Yamada, Hironari, Stallinga, Sjoerd, Offerman, S. Erik, Vliet, Lucas J. van, Photon Production Laboratory Ltd, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, and Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft. Characterization of an x-ray phase contrast imaging system based on the miniature synchrotron MIRRORCLE-6X. United States: N. p., 2011. Web. doi:10.1118/1.3622606.
Heekeren, Joop van, Kostenko, Alexander, Hanashima, Takayasu, Yamada, Hironari, Stallinga, Sjoerd, Offerman, S. Erik, Vliet, Lucas J. van, Photon Production Laboratory Ltd, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, & Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft. Characterization of an x-ray phase contrast imaging system based on the miniature synchrotron MIRRORCLE-6X. United States. doi:10.1118/1.3622606.
Heekeren, Joop van, Kostenko, Alexander, Hanashima, Takayasu, Yamada, Hironari, Stallinga, Sjoerd, Offerman, S. Erik, Vliet, Lucas J. van, Photon Production Laboratory Ltd, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, and Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft. Thu . "Characterization of an x-ray phase contrast imaging system based on the miniature synchrotron MIRRORCLE-6X". United States. doi:10.1118/1.3622606.
@article{osti_22098618,
title = {Characterization of an x-ray phase contrast imaging system based on the miniature synchrotron MIRRORCLE-6X},
author = {Heekeren, Joop van and Kostenko, Alexander and Hanashima, Takayasu and Yamada, Hironari and Stallinga, Sjoerd and Offerman, S. Erik and Vliet, Lucas J. van and Photon Production Laboratory Ltd, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577 and Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft and Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft and Quantitative Imaging Group, Department of Imaging Science and Technology, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft},
abstractNote = {Purpose: The implementation of in-line x-ray phase contrast imaging (PCI) for soft-tissue patient imaging is hampered by the lack of a bright and spatially coherent x-ray source that fits into the hospital environment. This article provides a quantitative characterization of the phase-contrast enhancement of a PCI system based on the miniature synchrotron technology MIRRORCLE-6X. Methods: The phase-contrast effect was measured using an edge response of a plexiglass plate as a function of the incident angle of radiation. We have developed a comprehensive x-ray propagation model based on the system's components, properties, and geometry in order to interpret the measurement data. Monte-Carlo simulations are used to estimate the system's spectral properties and resolution. Results: The measured ratio of the detected phase-contrast to the absorption contrast is currently in the range 100% to 200%. Experiments show that with the current implementation of the MIRRORCLE-6X, a target smaller than 30-40 {mu}m does not lead to a larger phase-contrast. The reason for this is that the fraction of x-rays produced by the material (carbon filament and glue) that is used for mounting the target in the electron beam is more than 25% of the total amount of x-rays produced. This increases the apparent source size. The measured phase-contrast is at maximum two times larger than the absorption contrast with the current set-up. Conclusions: Calculations based on our model of the present imaging system predict that the phase-contrast can be up to an order of magnitude larger than the absorption contrast in case the materials used for mounting the target in the electron beam do not (or hardly) produce x-rays. The methods described in this paper provide vital feedback for guiding future modifications to the design of the x-ray target of MIRRORCLE-type system and configuration of the in-line PCI systems in general.},
doi = {10.1118/1.3622606},
journal = {Medical Physics},
issn = {0094-2405},
number = 9,
volume = 38,
place = {United States},
year = {2011},
month = {9}
}