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Title: 4D analysis of influence of patient movement and anatomy alteration on the quality of 3D U/S-based prostate HDR brachytherapy treatment delivery

Abstract

Purpose: Modern HDR brachytherapy treatment for prostate cancer based on the 3D ultrasound (U/S) plays increasingly important role. The purpose of this study is to investigate possible patient movement and anatomy alteration between the clinical image set acquisition, made after the needle implantation, and the patient irradiation and their influence on the quality of treatment. Methods: The authors used 3D U/S image sets and the corresponding treatment plans based on a 4D-treatment planning procedure: plans of 25 patients are obtained right after the needle implantation (clinical plan is based on this 3D image set) and just before and after the treatment delivery. The authors notice the slight decrease of treatment quality with increase of time gap between the clinical image set acquisition and the patient irradiation. 4D analysis of dose-volume-histograms (DVHs) for prostate: CTV1 = PTV, and urethra, rectum, and bladder as organs at risk (OARs) and conformity index (COIN) is presented, demonstrating the effect of prostate, OARs, and needles displacement. Results: The authors show that in the case that the patient body movement/anatomy alteration takes place, this results in modification of DVHs and radiobiological parameters, hence the plan quality. The observed average displacement of needles (1 mm) and ofmore » prostate (0.57 mm) is quite small as compared with the average displacement noted in several other reports [A. A. Martinez et al., Int. J. Radiat. Oncol., Biol., Phys. 49(1), 61-69 (2001); S. J. Damore et al., Int. J. Radiat. Oncol., Biol., Phys. 46(5), 1205-1211 (2000); P. J. Hoskin et al., Radiotherm. Oncol. 68(3), 285-288 (2003); E. Mullokandov et al., Int. J. Radiat. Oncol., Biol., Phys. 58(4), 1063-1071 (2004)] in the literature. Conclusions: Although the decrease of quality of dosimetric and radiobiological parameters occurs, this does not cause clinically unacceptable changes to the 3D dose distribution, according to our clinical protocol.« less

Authors:
; ; ; ; ; ; ;  [1];  [2];  [3];  [3];  [3];  [4]
  1. Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main (Germany)
  2. (Sweden)
  3. (Germany)
  4. (Greece)
Publication Date:
OSTI Identifier:
22098609
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 38; Journal Issue: 9; Other Information: (c) 2011 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANATOMY; BLADDER; BRACHYTHERAPY; CARBON MONOXIDE; DOSIMETRY; HAZARDS; IMAGES; IRRADIATION; MODIFICATIONS; NEOPLASMS; PROSTATE; RADIATION DOSE DISTRIBUTIONS; RADIOBIOLOGY

Citation Formats

Milickovic, Natasa, Mavroidis, Panayiotis, Tselis, Nikolaos, Nikolova, Iliyana, Katsilieri, Zaira, Kefala, Vasiliki, Zamboglou, Nikolaos, Baltas, Dimos, Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, and Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Germany and Nuclear and Particle Physics Section, Physics Department, University of Athens, 15771 Athens. 4D analysis of influence of patient movement and anatomy alteration on the quality of 3D U/S-based prostate HDR brachytherapy treatment delivery. United States: N. p., 2011. Web. doi:10.1118/1.3618735.
Milickovic, Natasa, Mavroidis, Panayiotis, Tselis, Nikolaos, Nikolova, Iliyana, Katsilieri, Zaira, Kefala, Vasiliki, Zamboglou, Nikolaos, Baltas, Dimos, Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, & Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Germany and Nuclear and Particle Physics Section, Physics Department, University of Athens, 15771 Athens. 4D analysis of influence of patient movement and anatomy alteration on the quality of 3D U/S-based prostate HDR brachytherapy treatment delivery. United States. doi:10.1118/1.3618735.
Milickovic, Natasa, Mavroidis, Panayiotis, Tselis, Nikolaos, Nikolova, Iliyana, Katsilieri, Zaira, Kefala, Vasiliki, Zamboglou, Nikolaos, Baltas, Dimos, Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, and Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Germany and Nuclear and Particle Physics Section, Physics Department, University of Athens, 15771 Athens. Thu . "4D analysis of influence of patient movement and anatomy alteration on the quality of 3D U/S-based prostate HDR brachytherapy treatment delivery". United States. doi:10.1118/1.3618735.
@article{osti_22098609,
title = {4D analysis of influence of patient movement and anatomy alteration on the quality of 3D U/S-based prostate HDR brachytherapy treatment delivery},
author = {Milickovic, Natasa and Mavroidis, Panayiotis and Tselis, Nikolaos and Nikolova, Iliyana and Katsilieri, Zaira and Kefala, Vasiliki and Zamboglou, Nikolaos and Baltas, Dimos and Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University and Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main and Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main and Department of Radiation Oncology, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main and Department of Medical Physics and Engineering, Offenbach Clinic, Starkenburgring 66, 63069 Offenbach am Main, Germany and Nuclear and Particle Physics Section, Physics Department, University of Athens, 15771 Athens},
abstractNote = {Purpose: Modern HDR brachytherapy treatment for prostate cancer based on the 3D ultrasound (U/S) plays increasingly important role. The purpose of this study is to investigate possible patient movement and anatomy alteration between the clinical image set acquisition, made after the needle implantation, and the patient irradiation and their influence on the quality of treatment. Methods: The authors used 3D U/S image sets and the corresponding treatment plans based on a 4D-treatment planning procedure: plans of 25 patients are obtained right after the needle implantation (clinical plan is based on this 3D image set) and just before and after the treatment delivery. The authors notice the slight decrease of treatment quality with increase of time gap between the clinical image set acquisition and the patient irradiation. 4D analysis of dose-volume-histograms (DVHs) for prostate: CTV1 = PTV, and urethra, rectum, and bladder as organs at risk (OARs) and conformity index (COIN) is presented, demonstrating the effect of prostate, OARs, and needles displacement. Results: The authors show that in the case that the patient body movement/anatomy alteration takes place, this results in modification of DVHs and radiobiological parameters, hence the plan quality. The observed average displacement of needles (1 mm) and of prostate (0.57 mm) is quite small as compared with the average displacement noted in several other reports [A. A. Martinez et al., Int. J. Radiat. Oncol., Biol., Phys. 49(1), 61-69 (2001); S. J. Damore et al., Int. J. Radiat. Oncol., Biol., Phys. 46(5), 1205-1211 (2000); P. J. Hoskin et al., Radiotherm. Oncol. 68(3), 285-288 (2003); E. Mullokandov et al., Int. J. Radiat. Oncol., Biol., Phys. 58(4), 1063-1071 (2004)] in the literature. Conclusions: Although the decrease of quality of dosimetric and radiobiological parameters occurs, this does not cause clinically unacceptable changes to the 3D dose distribution, according to our clinical protocol.},
doi = {10.1118/1.3618735},
journal = {Medical Physics},
issn = {0094-2405},
number = 9,
volume = 38,
place = {United States},
year = {2011},
month = {9}
}