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Title: Cyclotron production of {sup 61}Cu using natural Zn and enriched {sup 64}Zn targets

Abstract

Copper-61 ({sup 61}Cu) shares with {sup 64}Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study {sup 61}Cu was produced using the {sup 64}Zn(p,{alpha}){sup 61}Cu reaction on natural Zn or enriched {sup 64}Zn targets. The enriched {sup 64}Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30{mu}A; at 11.7, 14.5 or 17.6MeV over 30-60min. The {sup 61}Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The {sup 64}Zn target material was recovered after each run, for re-use. In a direct comparison with enriched {sup 64}Zn-target results, {sup 61}Cu production using the cheaper {sup nat}Zn target proved to be an effective alternative.

Authors:
; ; ; ; ;  [1];  [2];  [3];  [3];  [3];  [3];  [3]
  1. RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia, Imaging and Applied Physics, Curtin University, Perth, Australia, and Center of Excellence in Anti-matter Matter Studies, Australian National University, Can (Australia)
  2. (United States) and Center of Excellence in Anti-matter Matter Studies, Australian National University, Canberra (Australia)
  3. (Australia)
Publication Date:
OSTI Identifier:
22075959
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1509; Journal Issue: 1; Conference: 14. international workshop on targetry and target chemistry, Playa del Carmen (Mexico), 26-29 Aug 2012; Other Information: (c) 2012 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPES AND RADIATION SOURCES; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; ALPHA PARTICLES; COMPARATIVE EVALUATIONS; COPPER 61; COPPER 64; CYCLOTRONS; ELECTROPLATING; FOILS; GOLD; HALF-LIFE; ION EXCHANGE; ISOTOPE PRODUCTION; ISOTOPE SEPARATION; PROTON REACTIONS; RADIOCHEMISTRY; SILVER; ZINC 64 TARGET

Citation Formats

Asad, A. H., Smith, S. V., Chan, S., Jeffery, C. M., Morandeau, L., Price, R. I., Brookhaven National Laboratory, Upton, NY, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Center of Excellence in Anti-matter Matter Studies, Australian National University, Canberra, Australia, and Chemistry, University of Western Australia, Pe, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, and RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia and Physics, University of Western Australia, Perth. Cyclotron production of {sup 61}Cu using natural Zn and enriched {sup 64}Zn targets. United States: N. p., 2012. Web. doi:10.1063/1.4773947.
Asad, A. H., Smith, S. V., Chan, S., Jeffery, C. M., Morandeau, L., Price, R. I., Brookhaven National Laboratory, Upton, NY, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Center of Excellence in Anti-matter Matter Studies, Australian National University, Canberra, Australia, and Chemistry, University of Western Australia, Pe, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, & RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia and Physics, University of Western Australia, Perth. Cyclotron production of {sup 61}Cu using natural Zn and enriched {sup 64}Zn targets. United States. doi:10.1063/1.4773947.
Asad, A. H., Smith, S. V., Chan, S., Jeffery, C. M., Morandeau, L., Price, R. I., Brookhaven National Laboratory, Upton, NY, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Center of Excellence in Anti-matter Matter Studies, Australian National University, Canberra, Australia, and Chemistry, University of Western Australia, Pe, RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, and RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia and Physics, University of Western Australia, Perth. Wed . "Cyclotron production of {sup 61}Cu using natural Zn and enriched {sup 64}Zn targets". United States. doi:10.1063/1.4773947.
@article{osti_22075959,
title = {Cyclotron production of {sup 61}Cu using natural Zn and enriched {sup 64}Zn targets},
author = {Asad, A. H. and Smith, S. V. and Chan, S. and Jeffery, C. M. and Morandeau, L. and Price, R. I. and Brookhaven National Laboratory, Upton, NY and RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth and RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth and Center of Excellence in Anti-matter Matter Studies, Australian National University, Canberra, Australia, and Chemistry, University of Western Australia, Pe and RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth and RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia and Physics, University of Western Australia, Perth},
abstractNote = {Copper-61 ({sup 61}Cu) shares with {sup 64}Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study {sup 61}Cu was produced using the {sup 64}Zn(p,{alpha}){sup 61}Cu reaction on natural Zn or enriched {sup 64}Zn targets. The enriched {sup 64}Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30{mu}A; at 11.7, 14.5 or 17.6MeV over 30-60min. The {sup 61}Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The {sup 64}Zn target material was recovered after each run, for re-use. In a direct comparison with enriched {sup 64}Zn-target results, {sup 61}Cu production using the cheaper {sup nat}Zn target proved to be an effective alternative.},
doi = {10.1063/1.4773947},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1509,
place = {United States},
year = {2012},
month = {12}
}