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Title: Dosimetric comparison of volumetric modulated Arc therapy, step-and-shoot, and sliding window IMRT for prostate cancer

Abstract

This study aims to evaluate treatment plans generated by Step-and-Shoot (SS), Sliding Window (SW) and Volumetric Modulated Arc Therapy (VMAT) in order to assess the differences in dose volume histograms of planning target volume (PTV) and organs at risk (OAR), conformity indices, radiobiological evaluations, and plan quality for prostate cancer cases. Six prostate cancer patients treated in our center were selected for this retrospective study. Treatment plans were generated with Eclipse version 8.9 using 10 MV photon beams. For VMAT, Varian Rapid Arc with 1 or 2 arcs, and for SS and SW IMRT, 7-9 fields were used. Each plan had three PTVs with prescription doses of 81, 59.4, and 45 Gy to prostate, to prostate and lymph nodes, and to pelvis, respectively. Doses to PTV and OAR and the conformal indices (COIN) were compared among three techniques. The equivalent uniform dose (EUD), tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated and compared. The mean doses to the PTV prostate on average were 83 Gy and the percent differences of mean dose among all techniques were below 0.28. For bladder and rectum, the percent differences of mean dose among all techniques were below 2.2. The COINmore » did not favour any particular delivery method over the other. The TCP was higher with SS and SW for four patients and higher with VMAT for two patients. The NTCP for the rectum was the lowest with VMAT in five out of the six patients. The results show similar target coverage in general.« less

Authors:
; ; ; ; ; ; ;  [1]
  1. Department of Radiation Oncology, University of Oklahoma Health Sciences Center 800 N.E. 10th St., OKCC L100, Oklahoma City, OK 73104 (United States)
Publication Date:
OSTI Identifier:
22075684
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1494; Journal Issue: 1; Conference: 12. Mexican symposium on medical physics, Oaxaca (Mexico), 16-19 Mar 2012; Other Information: (c) 2012 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY; BLADDER; COMPARATIVE EVALUATIONS; CONTROL; GAMMA DOSIMETRY; LYMPH NODES; NEOPLASMS; PATIENTS; PELVIS; PHOTON BEAMS; PROBABILITY; PROSTATE; RADIATION DOSES; RADIOTHERAPY; RECTUM

Citation Formats

Schnell, Erich, De La Fuente Herman, Tania, Young, Julie, Hildebrand, Kim, Algan, Ozer, Syzek, Elizabeth, Herman, Terence, and Ahmad, Salahuddin. Dosimetric comparison of volumetric modulated Arc therapy, step-and-shoot, and sliding window IMRT for prostate cancer. United States: N. p., 2012. Web. doi:10.1063/1.4764589.
Schnell, Erich, De La Fuente Herman, Tania, Young, Julie, Hildebrand, Kim, Algan, Ozer, Syzek, Elizabeth, Herman, Terence, & Ahmad, Salahuddin. Dosimetric comparison of volumetric modulated Arc therapy, step-and-shoot, and sliding window IMRT for prostate cancer. United States. doi:10.1063/1.4764589.
Schnell, Erich, De La Fuente Herman, Tania, Young, Julie, Hildebrand, Kim, Algan, Ozer, Syzek, Elizabeth, Herman, Terence, and Ahmad, Salahuddin. Tue . "Dosimetric comparison of volumetric modulated Arc therapy, step-and-shoot, and sliding window IMRT for prostate cancer". United States. doi:10.1063/1.4764589.
@article{osti_22075684,
title = {Dosimetric comparison of volumetric modulated Arc therapy, step-and-shoot, and sliding window IMRT for prostate cancer},
author = {Schnell, Erich and De La Fuente Herman, Tania and Young, Julie and Hildebrand, Kim and Algan, Ozer and Syzek, Elizabeth and Herman, Terence and Ahmad, Salahuddin},
abstractNote = {This study aims to evaluate treatment plans generated by Step-and-Shoot (SS), Sliding Window (SW) and Volumetric Modulated Arc Therapy (VMAT) in order to assess the differences in dose volume histograms of planning target volume (PTV) and organs at risk (OAR), conformity indices, radiobiological evaluations, and plan quality for prostate cancer cases. Six prostate cancer patients treated in our center were selected for this retrospective study. Treatment plans were generated with Eclipse version 8.9 using 10 MV photon beams. For VMAT, Varian Rapid Arc with 1 or 2 arcs, and for SS and SW IMRT, 7-9 fields were used. Each plan had three PTVs with prescription doses of 81, 59.4, and 45 Gy to prostate, to prostate and lymph nodes, and to pelvis, respectively. Doses to PTV and OAR and the conformal indices (COIN) were compared among three techniques. The equivalent uniform dose (EUD), tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated and compared. The mean doses to the PTV prostate on average were 83 Gy and the percent differences of mean dose among all techniques were below 0.28. For bladder and rectum, the percent differences of mean dose among all techniques were below 2.2. The COIN did not favour any particular delivery method over the other. The TCP was higher with SS and SW for four patients and higher with VMAT for two patients. The NTCP for the rectum was the lowest with VMAT in five out of the six patients. The results show similar target coverage in general.},
doi = {10.1063/1.4764589},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1494,
place = {United States},
year = {2012},
month = {10}
}