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Title: Hybrid quadrupole mass filter/quadrupole ion trap/time-of-flight-mass spectrometer for infrared multiple photon dissociation spectroscopy of mass-selected ions

Abstract

We present a laboratory-constructed mass spectrometer optimized for recording infrared multiple photon dissociation (IRMPD) spectra of mass-selected ions using a benchtop tunable infrared optical parametric oscillator/amplifier (OPO/A). The instrument is equipped with two ionization sources, an electrospray ionization source, as well as an electron ionization source for troubleshooting. This hybrid mass spectrometer is composed of a quadrupole mass filter for mass selection, a reduced pressure ({approx}10{sup -5} Torr) quadrupole ion trap (QIT) for OPO irradiation, and a reflectron time-of-flight drift tube for detecting the remaining precursor and photofragment ions. A helium gas pulse is introduced into the QIT to temporarily increase the pressure and hence enhance the trapping efficiency of axially injected ions. After a brief pump-down delay, the compact ion cloud is subjected to the focused output from the continuous wave OPO. In a recent study, we implemented this setup in the study of protonated tryptophan, TrpH{sup +}, as well as collision-induced dissociation products of this protonated amino acid [W. K. Mino, Jr., K. Gulyuz, D. Wang, C. N. Stedwell, and N. C. Polfer, J. Phys. Chem. Lett. 2, 299 (2011)]. Here, we give a more detailed account on the figures of merit of such IRMPD experiments. The appreciablemore » photodissociation yields in these measurements demonstrate that IRMPD spectroscopy of covalently bound ions can be routinely carried out using benchtop OPO setups.« less

Authors:
; ; ;  [1]
  1. Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, Florida 32611 (United States)
Publication Date:
OSTI Identifier:
22062330
Resource Type:
Journal Article
Journal Name:
Review of Scientific Instruments
Additional Journal Information:
Journal Volume: 82; Journal Issue: 5; Other Information: (c) 2011 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0034-6748
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; COVALENCE; DISSOCIATION; DRIFT TUBES; EFFICIENCY; ELECTRONS; HELIUM; INFRARED SPECTRA; IONIZATION; IONS; IRRADIATION; PARAMETRIC AMPLIFIERS; PARAMETRIC OSCILLATORS; PHOTOLYSIS; PHOTONS; PULSES; TIME-OF-FLIGHT MASS SPECTROMETERS; TIME-OF-FLIGHT METHOD; TRAPPING; TRYPTOPHAN

Citation Formats

Gulyuz, Kerim, Stedwell, Corey N, Da, Wang, and Polfer, Nick C. Hybrid quadrupole mass filter/quadrupole ion trap/time-of-flight-mass spectrometer for infrared multiple photon dissociation spectroscopy of mass-selected ions. United States: N. p., 2011. Web. doi:10.1063/1.3585982.
Gulyuz, Kerim, Stedwell, Corey N, Da, Wang, & Polfer, Nick C. Hybrid quadrupole mass filter/quadrupole ion trap/time-of-flight-mass spectrometer for infrared multiple photon dissociation spectroscopy of mass-selected ions. United States. https://doi.org/10.1063/1.3585982
Gulyuz, Kerim, Stedwell, Corey N, Da, Wang, and Polfer, Nick C. 2011. "Hybrid quadrupole mass filter/quadrupole ion trap/time-of-flight-mass spectrometer for infrared multiple photon dissociation spectroscopy of mass-selected ions". United States. https://doi.org/10.1063/1.3585982.
@article{osti_22062330,
title = {Hybrid quadrupole mass filter/quadrupole ion trap/time-of-flight-mass spectrometer for infrared multiple photon dissociation spectroscopy of mass-selected ions},
author = {Gulyuz, Kerim and Stedwell, Corey N and Da, Wang and Polfer, Nick C},
abstractNote = {We present a laboratory-constructed mass spectrometer optimized for recording infrared multiple photon dissociation (IRMPD) spectra of mass-selected ions using a benchtop tunable infrared optical parametric oscillator/amplifier (OPO/A). The instrument is equipped with two ionization sources, an electrospray ionization source, as well as an electron ionization source for troubleshooting. This hybrid mass spectrometer is composed of a quadrupole mass filter for mass selection, a reduced pressure ({approx}10{sup -5} Torr) quadrupole ion trap (QIT) for OPO irradiation, and a reflectron time-of-flight drift tube for detecting the remaining precursor and photofragment ions. A helium gas pulse is introduced into the QIT to temporarily increase the pressure and hence enhance the trapping efficiency of axially injected ions. After a brief pump-down delay, the compact ion cloud is subjected to the focused output from the continuous wave OPO. In a recent study, we implemented this setup in the study of protonated tryptophan, TrpH{sup +}, as well as collision-induced dissociation products of this protonated amino acid [W. K. Mino, Jr., K. Gulyuz, D. Wang, C. N. Stedwell, and N. C. Polfer, J. Phys. Chem. Lett. 2, 299 (2011)]. Here, we give a more detailed account on the figures of merit of such IRMPD experiments. The appreciable photodissociation yields in these measurements demonstrate that IRMPD spectroscopy of covalently bound ions can be routinely carried out using benchtop OPO setups.},
doi = {10.1063/1.3585982},
url = {https://www.osti.gov/biblio/22062330}, journal = {Review of Scientific Instruments},
issn = {0034-6748},
number = 5,
volume = 82,
place = {United States},
year = {Sun May 15 00:00:00 EDT 2011},
month = {Sun May 15 00:00:00 EDT 2011}
}