Role of Early Postradiation Magnetic Resonance Imaging Scans in Children With Diffuse Intrinsic Pontine Glioma

Ko, Christine; Kaushal, Aradhana; Hammoud, Dima A; Steffen-Smith, Emilie A; Bent, Robyn; Citrin, Deborah; Camphausen, Kevin; Warren, Katherine E

doi:10.1016/J.IJROBP.2011.09.046

Title: Role of Early Postradiation Magnetic Resonance Imaging Scans in Children With Diffuse Intrinsic Pontine Glioma

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Abstract

Purpose: To determine optimal timing of assessing postradiation radiographic response on magnetic resonance imaging (MRI) scans in pediatric patients with diffuse intrinsic pontine glioma (DIPG). Methods and Materials: Patients were treated on a prospective study at the National Cancer Institute (Protocol no. 06-C-0219) evaluating the effects of radiotherapy (RT). Standard RT was administered in standard fractionation over 6 weeks. Postradiation MRI scans were performed at 2 and 6-8 weeks. Results: Eleven patients with DIPG were evaluated. Median age was 6 years (range, 4-13 years). Patients were treated with external-beam RT to 55.8 Gy (n = 10) or 54 Gy (n = 1), with a gross tumor volume to planning target volume expansion of 1.8-2.0 cm. All patients received prescribed dose and underwent posttreatment MRI scans at 2 and 6-8 weeks. Pretreatment imaging revealed compression of fourth ventricle (n = 11); basilar artery encasement (n = 9); tumor extension outside the pons (n = 11); and tumor hemorrhage (n = 2). At the 2-week scan, basilar artery encasement improved in 7 of 9 patients, and extent of tumor was reduced in 5 of 11 patients. Fourth ventricle compression improved in 6 of 11 patients but worsened in 3 of 11 patients.more »« less

Authors:

Ko, Christine ^[1]; Kaushal, Aradhana ^[1]; Hammoud, Dima A ^[2]; Steffen-Smith, Emilie A; Bent, Robyn ^[3]; Citrin, Deborah; Camphausen, Kevin ^[1]; Warren, Katherine E ^[3]

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States)
Radiology and Imaging Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States)
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States)

Publication Date:: Sun Jul 15 00:00:00 EDT 2012

OSTI Identifier:: 22058971

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 83; Journal Issue: 4; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; CHILDREN; GLIOMAS; HEMORRHAGE; MALFORMATIONS; NECROSIS; NMR IMAGING; PATIENTS; PEDIATRICS; PLANNING; RADIATION DOSES; RADIOTHERAPY

Citation Formats


                    Ko, Christine, Kaushal, Aradhana, Hammoud, Dima A, Steffen-Smith, Emilie A, Bent, Robyn, Citrin, Deborah, Camphausen, Kevin, and Warren, Katherine E. Role of Early Postradiation Magnetic Resonance Imaging Scans in Children With Diffuse Intrinsic Pontine Glioma.  United States: N. p., 2012. 
        Web.  doi:10.1016/J.IJROBP.2011.09.046.

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                    Ko, Christine, Kaushal, Aradhana, Hammoud, Dima A, Steffen-Smith, Emilie A, Bent, Robyn, Citrin, Deborah, Camphausen, Kevin, & Warren, Katherine E. Role of Early Postradiation Magnetic Resonance Imaging Scans in Children With Diffuse Intrinsic Pontine Glioma.  United States.  https://doi.org/10.1016/J.IJROBP.2011.09.046

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                    Ko, Christine, Kaushal, Aradhana, Hammoud, Dima A, Steffen-Smith, Emilie A, Bent, Robyn, Citrin, Deborah, Camphausen, Kevin, and Warren, Katherine E. 2012.  
        "Role of Early Postradiation Magnetic Resonance Imaging Scans in Children With Diffuse Intrinsic Pontine Glioma".  United States.  https://doi.org/10.1016/J.IJROBP.2011.09.046.

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@article{osti_22058971,

  title        = {Role of Early Postradiation Magnetic Resonance Imaging Scans in Children With Diffuse Intrinsic Pontine Glioma},

  author       = {Ko, Christine and Kaushal, Aradhana and Hammoud, Dima A and Steffen-Smith, Emilie A and Bent, Robyn and Citrin, Deborah and Camphausen, Kevin and Warren, Katherine E},

  abstractNote = {Purpose: To determine optimal timing of assessing postradiation radiographic response on magnetic resonance imaging (MRI) scans in pediatric patients with diffuse intrinsic pontine glioma (DIPG). Methods and Materials: Patients were treated on a prospective study at the National Cancer Institute (Protocol no. 06-C-0219) evaluating the effects of radiotherapy (RT). Standard RT was administered in standard fractionation over 6 weeks. Postradiation MRI scans were performed at 2 and 6-8 weeks. Results: Eleven patients with DIPG were evaluated. Median age was 6 years (range, 4-13 years). Patients were treated with external-beam RT to 55.8 Gy (n = 10) or 54 Gy (n = 1), with a gross tumor volume to planning target volume expansion of 1.8-2.0 cm. All patients received prescribed dose and underwent posttreatment MRI scans at 2 and 6-8 weeks. Pretreatment imaging revealed compression of fourth ventricle (n = 11); basilar artery encasement (n = 9); tumor extension outside the pons (n = 11); and tumor hemorrhage (n = 2). At the 2-week scan, basilar artery encasement improved in 7 of 9 patients, and extent of tumor was reduced in 5 of 11 patients. Fourth ventricle compression improved in 6 of 11 patients but worsened in 3 of 11 patients. Presumed necrosis was observed in 5 of 11 patients at 2 weeks and in 1 additional patient at 6-8 weeks. There was no significant difference in mean anteroposterior and transverse diameters of tumor between the 2- and 6-8-week time points. Six of 11 patients had increasing ventricular size, with no evidence of obstruction. Conclusions: There is no significant difference in tumor size of DIPG patients who have received standard RT when measured at 2 weeks vs. 6-8 weeks after RT. The majority of patients had the largest change in tumor size at the 2-week post-RT scan, with evolving changes documented on the 6-8-week scan. Six of 11 patients had progressive ventriculomegaly without obstruction, suggestive of communicating hydrocephalus. To the best of our knowledge, this is the first documentation of this phenomenon in this cohort of patients.},

  doi          = {10.1016/J.IJROBP.2011.09.046},

  url          = {https://www.osti.gov/biblio/22058971},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 4,

  volume       = 83,

  place        = {United States},

  year         = {Sun Jul 15 00:00:00 EDT 2012},

  month        = {Sun Jul 15 00:00:00 EDT 2012}

}

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