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Title: Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes

Abstract

Purpose: The indication for postmastectomy radiotherapy (PMRT) in breast cancer patients with one to three positive lymph nodes has been in discussion. The purpose of this study was to identify patient groups for whom PMRT may be indicated, focusing on varied locoregional recurrence rates depending on lymphatic invasion (ly) status. Methods and Materials: Retrospective analysis of 1,994 node-positive patients who had undergone mastectomy without postoperative radiotherapy between January 1990 and December 2000 at our hospital was performed. Patient groups for whom PMRT should be indicated were assessed using statistical tests based on the relationship between locoregional recurrence rate and ly status. Results: Multivariate analysis showed that the ly status affected the locoregional recurrence rate to as great a degree as the number of positive lymph nodes (p < 0.001). Especially for patients with one to three positive nodes, extensive ly was a more significant factor than stage T3 in the TNM staging system for locoregional recurrence (p < 0.001 vs. p = 0.295). Conclusion: Among postmastectomy patients with one to three positive lymph nodes, patients with extensive ly seem to require local therapy regimens similar to those used for patients with four or more positive nodes and also seem tomore » require consideration of the use of PMRT.« less

Authors:
 [1];  [2];  [3];  [1];  [4]; ; ; ; ; ; ; ;  [1];  [5];  [6];  [7];  [1]
  1. Department of Surgery, Breast Oncology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan)
  2. (Japan)
  3. Radiation Oncology Department, Breast Oncology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan)
  4. Bioinformatics Group, Genome Center of the Japanese Foundation for Cancer Research and Division of Cancer Genomics, Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo (Japan)
  5. Department of Diagnostic Imaging, Breast Oncology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan)
  6. Division of Pathology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan)
  7. Division of Pathology, Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo (Japan)
Publication Date:
OSTI Identifier:
22058883
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 83; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LYMPH NODES; MAMMARY GLANDS; MULTIVARIATE ANALYSIS; NEOPLASMS; PATIENTS; RADIOTHERAPY

Citation Formats

Matsunuma, Ryoichi, E-mail: r-matsunuma@nifty.com, First Department of Surgery, Hamamatsu University School of Medicine, Shizuoka, Oguchi, Masahiko, Fujikane, Tomoko, Matsuura, Masaaki, Sakai, Takehiko, Kimura, Kiyomi, Morizono, Hidetomo, Iijima, Kotaro, Izumori, Ayumi, Miyagi, Yumi, Nishimura, Seiichiro, Makita, Masujiro, Gomi, Naoya, Horii, Rie, Akiyama, Futoshi, and Iwase, Takuji. Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.08.029.
Matsunuma, Ryoichi, E-mail: r-matsunuma@nifty.com, First Department of Surgery, Hamamatsu University School of Medicine, Shizuoka, Oguchi, Masahiko, Fujikane, Tomoko, Matsuura, Masaaki, Sakai, Takehiko, Kimura, Kiyomi, Morizono, Hidetomo, Iijima, Kotaro, Izumori, Ayumi, Miyagi, Yumi, Nishimura, Seiichiro, Makita, Masujiro, Gomi, Naoya, Horii, Rie, Akiyama, Futoshi, & Iwase, Takuji. Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes. United States. doi:10.1016/J.IJROBP.2011.08.029.
Matsunuma, Ryoichi, E-mail: r-matsunuma@nifty.com, First Department of Surgery, Hamamatsu University School of Medicine, Shizuoka, Oguchi, Masahiko, Fujikane, Tomoko, Matsuura, Masaaki, Sakai, Takehiko, Kimura, Kiyomi, Morizono, Hidetomo, Iijima, Kotaro, Izumori, Ayumi, Miyagi, Yumi, Nishimura, Seiichiro, Makita, Masujiro, Gomi, Naoya, Horii, Rie, Akiyama, Futoshi, and Iwase, Takuji. Sun . "Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes". United States. doi:10.1016/J.IJROBP.2011.08.029.
@article{osti_22058883,
title = {Influence of Lymphatic Invasion on Locoregional Recurrence Following Mastectomy: Indication for Postmastectomy Radiotherapy for Breast Cancer Patients With One to Three Positive Nodes},
author = {Matsunuma, Ryoichi, E-mail: r-matsunuma@nifty.com and First Department of Surgery, Hamamatsu University School of Medicine, Shizuoka and Oguchi, Masahiko and Fujikane, Tomoko and Matsuura, Masaaki and Sakai, Takehiko and Kimura, Kiyomi and Morizono, Hidetomo and Iijima, Kotaro and Izumori, Ayumi and Miyagi, Yumi and Nishimura, Seiichiro and Makita, Masujiro and Gomi, Naoya and Horii, Rie and Akiyama, Futoshi and Iwase, Takuji},
abstractNote = {Purpose: The indication for postmastectomy radiotherapy (PMRT) in breast cancer patients with one to three positive lymph nodes has been in discussion. The purpose of this study was to identify patient groups for whom PMRT may be indicated, focusing on varied locoregional recurrence rates depending on lymphatic invasion (ly) status. Methods and Materials: Retrospective analysis of 1,994 node-positive patients who had undergone mastectomy without postoperative radiotherapy between January 1990 and December 2000 at our hospital was performed. Patient groups for whom PMRT should be indicated were assessed using statistical tests based on the relationship between locoregional recurrence rate and ly status. Results: Multivariate analysis showed that the ly status affected the locoregional recurrence rate to as great a degree as the number of positive lymph nodes (p < 0.001). Especially for patients with one to three positive nodes, extensive ly was a more significant factor than stage T3 in the TNM staging system for locoregional recurrence (p < 0.001 vs. p = 0.295). Conclusion: Among postmastectomy patients with one to three positive lymph nodes, patients with extensive ly seem to require local therapy regimens similar to those used for patients with four or more positive nodes and also seem to require consideration of the use of PMRT.},
doi = {10.1016/J.IJROBP.2011.08.029},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 83,
place = {United States},
year = {2012},
month = {7}
}