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Title: IMRT for Image-Guided Single Vocal Cord Irradiation

Abstract

Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques. Methods and Materials: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions. Results: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose {+-} standard deviation to the planning target volume was 67 {+-} 1 Gy. The contralateral vocal cord dose was reduced from 66 {+-} 1 Gy in the conventional plans to 39 {+-} 8 Gy and 36 {+-} 6 Gy in themore » coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk. Conclusions: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.« less

Authors:
 [1]; ; ; ; ; ; ; ;  [1]
  1. Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)
Publication Date:
OSTI Identifier:
22056080
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 82; Journal Issue: 2; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; CARCINOMAS; CAROTID ARTERIES; CONTROL; HAZARDS; IMAGES; IRRADIATION; MONTE CARLO METHOD; MUSCLES; OPTIMIZATION; PATIENTS; PHOTON BEAMS; PLANNING; RADIATION DOSES; RADIOTHERAPY; SPINAL CORD; STANDARD OF LIVING

Citation Formats

Osman, Sarah O.S., E-mail: s.osman@erasmusmc.nl, Astreinidou, Eleftheria, Boer, Hans C.J. de, Keskin-Cambay, Fatma, Breedveld, Sebastiaan, Voet, Peter, Al-Mamgani, Abrahim, Heijmen, Ben J.M., and Levendag, Peter C. IMRT for Image-Guided Single Vocal Cord Irradiation. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2010.12.022.
Osman, Sarah O.S., E-mail: s.osman@erasmusmc.nl, Astreinidou, Eleftheria, Boer, Hans C.J. de, Keskin-Cambay, Fatma, Breedveld, Sebastiaan, Voet, Peter, Al-Mamgani, Abrahim, Heijmen, Ben J.M., & Levendag, Peter C. IMRT for Image-Guided Single Vocal Cord Irradiation. United States. doi:10.1016/J.IJROBP.2010.12.022.
Osman, Sarah O.S., E-mail: s.osman@erasmusmc.nl, Astreinidou, Eleftheria, Boer, Hans C.J. de, Keskin-Cambay, Fatma, Breedveld, Sebastiaan, Voet, Peter, Al-Mamgani, Abrahim, Heijmen, Ben J.M., and Levendag, Peter C. Wed . "IMRT for Image-Guided Single Vocal Cord Irradiation". United States. doi:10.1016/J.IJROBP.2010.12.022.
@article{osti_22056080,
title = {IMRT for Image-Guided Single Vocal Cord Irradiation},
author = {Osman, Sarah O.S., E-mail: s.osman@erasmusmc.nl and Astreinidou, Eleftheria and Boer, Hans C.J. de and Keskin-Cambay, Fatma and Breedveld, Sebastiaan and Voet, Peter and Al-Mamgani, Abrahim and Heijmen, Ben J.M. and Levendag, Peter C.},
abstractNote = {Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques. Methods and Materials: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions. Results: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose {+-} standard deviation to the planning target volume was 67 {+-} 1 Gy. The contralateral vocal cord dose was reduced from 66 {+-} 1 Gy in the conventional plans to 39 {+-} 8 Gy and 36 {+-} 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk. Conclusions: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.},
doi = {10.1016/J.IJROBP.2010.12.022},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 82,
place = {United States},
year = {2012},
month = {2}
}