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Title: Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis

Abstract

Purpose: During the past two decades, radiosurgery has arisen as a promising approach to the management of glomus jugulare. In the present study, we report on a systematic review and meta-analysis of the available published data on the radiosurgical management of glomus jugulare tumors. Methods and Materials: To identify eligible studies, systematic searches of all glomus jugulare tumors treated with radiosurgery were conducted in major scientific publication databases. The data search yielded 19 studies, which were included in the meta-analysis. The data from 335 glomus jugulare patients were extracted. The fixed effects pooled proportions were calculated from the data when Cochrane's statistic was statistically insignificant and the inconsistency among studies was <25%. Bias was assessed using the Egger funnel plot test. Results: Across all studies, 97% of patients achieved tumor control, and 95% of patients achieved clinical control. Eight studies reported a mean or median follow-up time of >36 months. In these studies, 95% of patients achieved clinical control and 96% achieved tumor control. The gamma knife, linear accelerator, and CyberKnife technologies all exhibited high rates of tumor and clinical control. Conclusions: The present study reports the results of a meta-analysis for the radiosurgical management of glomus jugulare. Because ofmore » its high effectiveness, we suggest considering radiosurgery for the primary management of glomus jugulare tumors.« less

Authors:
;  [1];  [2];  [3];  [4];  [5];  [1];  [4];  [3];  [5];  [1]
  1. Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD (United States)
  2. Department of Otolaryngology, Johns Hopkins Hospital, Baltimore, MD (United States)
  3. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA (United States)
  4. Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States)
  5. Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, MD (United States)
Publication Date:
OSTI Identifier:
22054418
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 81; Journal Issue: 4; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LINEAR ACCELERATORS; NEOPLASMS; PATIENTS; RADIOTHERAPY; SURGERY

Citation Formats

Guss, Zachary D., Batra, Sachin, Limb, Charles J., Li, Gordon, Sughrue, Michael E., Redmond, Kristin, Rigamonti, Daniele, Parsa, Andrew T., Chang, Steven, Kleinberg, Lawrence, and Lim, Michael, E-mail: mlim3@jhmi.edu. Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis. United States: N. p., 2011. Web. doi:10.1016/J.IJROBP.2011.05.006.
Guss, Zachary D., Batra, Sachin, Limb, Charles J., Li, Gordon, Sughrue, Michael E., Redmond, Kristin, Rigamonti, Daniele, Parsa, Andrew T., Chang, Steven, Kleinberg, Lawrence, & Lim, Michael, E-mail: mlim3@jhmi.edu. Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis. United States. doi:10.1016/J.IJROBP.2011.05.006.
Guss, Zachary D., Batra, Sachin, Limb, Charles J., Li, Gordon, Sughrue, Michael E., Redmond, Kristin, Rigamonti, Daniele, Parsa, Andrew T., Chang, Steven, Kleinberg, Lawrence, and Lim, Michael, E-mail: mlim3@jhmi.edu. Tue . "Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis". United States. doi:10.1016/J.IJROBP.2011.05.006.
@article{osti_22054418,
title = {Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis},
author = {Guss, Zachary D. and Batra, Sachin and Limb, Charles J. and Li, Gordon and Sughrue, Michael E. and Redmond, Kristin and Rigamonti, Daniele and Parsa, Andrew T. and Chang, Steven and Kleinberg, Lawrence and Lim, Michael, E-mail: mlim3@jhmi.edu},
abstractNote = {Purpose: During the past two decades, radiosurgery has arisen as a promising approach to the management of glomus jugulare. In the present study, we report on a systematic review and meta-analysis of the available published data on the radiosurgical management of glomus jugulare tumors. Methods and Materials: To identify eligible studies, systematic searches of all glomus jugulare tumors treated with radiosurgery were conducted in major scientific publication databases. The data search yielded 19 studies, which were included in the meta-analysis. The data from 335 glomus jugulare patients were extracted. The fixed effects pooled proportions were calculated from the data when Cochrane's statistic was statistically insignificant and the inconsistency among studies was <25%. Bias was assessed using the Egger funnel plot test. Results: Across all studies, 97% of patients achieved tumor control, and 95% of patients achieved clinical control. Eight studies reported a mean or median follow-up time of >36 months. In these studies, 95% of patients achieved clinical control and 96% achieved tumor control. The gamma knife, linear accelerator, and CyberKnife technologies all exhibited high rates of tumor and clinical control. Conclusions: The present study reports the results of a meta-analysis for the radiosurgical management of glomus jugulare. Because of its high effectiveness, we suggest considering radiosurgery for the primary management of glomus jugulare tumors.},
doi = {10.1016/J.IJROBP.2011.05.006},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 81,
place = {United States},
year = {2011},
month = {11}
}