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Title: Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo

Abstract

The delivery of gold nanoparticles (nanocages coated with a layer of silicon dioxide (40/20 nm)) dispersed in the solution (glycerol + polyethylene glycol-400, 1 : 1) into the skin tissue is studied experimentally in vivo. From the data of optical coherence tomography and histochemical analysis it follows that simple application of suspension of nanoparticles is not efficient enough for delivery of the particles into the skin as a result of passive diffusion. It is shown that fractional laser microablation of skin before the application of the suspension, followed by the topical treatment by ultrasound allows penetration through the epidermis layer and delivery of nanoparticles into dermis and hypodermis.

Authors:
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Publication Date:
OSTI Identifier:
22043937
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 42; Journal Issue: 6; Other Information: Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; BIOPHYSICS; DELIVERY; DIFFUSION; EPIDERMIS; GLYCEROL; GOLD; IN VIVO; LASER RADIATION; LAYERS; NANOSTRUCTURES; PARTICLES; POLYETHYLENE GLYCOLS; SILICON OXIDES; SUSPENSIONS; TOMOGRAPHY

Citation Formats

Terentyuk, G S, Genina, Elina A, Bashkatov, A N, Ryzhova, M V, Tsyganova, N A, Chumakov, D S, Khlebtsov, B N, Sazonov, A A, Dolotov, L E, Tuchin, Valerii V, Khlebtsov, Nikolai G, and Inozemtseva, O A. Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo. United States: N. p., 2012. Web. doi:10.1070/QE2012V042N06ABEH014882.
Terentyuk, G S, Genina, Elina A, Bashkatov, A N, Ryzhova, M V, Tsyganova, N A, Chumakov, D S, Khlebtsov, B N, Sazonov, A A, Dolotov, L E, Tuchin, Valerii V, Khlebtsov, Nikolai G, & Inozemtseva, O A. Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo. United States. doi:10.1070/QE2012V042N06ABEH014882.
Terentyuk, G S, Genina, Elina A, Bashkatov, A N, Ryzhova, M V, Tsyganova, N A, Chumakov, D S, Khlebtsov, B N, Sazonov, A A, Dolotov, L E, Tuchin, Valerii V, Khlebtsov, Nikolai G, and Inozemtseva, O A. Sat . "Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo". United States. doi:10.1070/QE2012V042N06ABEH014882.
@article{osti_22043937,
title = {Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo},
author = {Terentyuk, G S and Genina, Elina A and Bashkatov, A N and Ryzhova, M V and Tsyganova, N A and Chumakov, D S and Khlebtsov, B N and Sazonov, A A and Dolotov, L E and Tuchin, Valerii V and Khlebtsov, Nikolai G and Inozemtseva, O A},
abstractNote = {The delivery of gold nanoparticles (nanocages coated with a layer of silicon dioxide (40/20 nm)) dispersed in the solution (glycerol + polyethylene glycol-400, 1 : 1) into the skin tissue is studied experimentally in vivo. From the data of optical coherence tomography and histochemical analysis it follows that simple application of suspension of nanoparticles is not efficient enough for delivery of the particles into the skin as a result of passive diffusion. It is shown that fractional laser microablation of skin before the application of the suspension, followed by the topical treatment by ultrasound allows penetration through the epidermis layer and delivery of nanoparticles into dermis and hypodermis.},
doi = {10.1070/QE2012V042N06ABEH014882},
journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 6,
volume = 42,
place = {United States},
year = {2012},
month = {6}
}