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Title: Depth-resolved monitoring of diffusion of hyperosmotic agents in normal and malignant human esophagus tissues using optical coherence tomography in-vitro

Abstract

Depth-resolved monitoring with differentiation and quantification of glucose diffusion in healthy and abnormal esophagus tissues has been studied in vitro. Experiments have been performed using human normal esophagus and esophageal squamous cell carcinoma (ESCC) tissues by the optical coherence tomography (OCT). The images have been continuously acquired for 120 min in the experiments, and the depth-resolved and average permeability coefficients of the 40 % glucose solution have been calculated by the OCT amplitude (OCTA) method. We demonstrate the capability of the OCT technique for depth-resolved monitoring, differentiation, and quantifying of glucose diffusion in normal esophagus and ESCC tissues. It is found that the permeability coefficients of the 40 % glucose solution are not uniform throughout the normal esophagus and ESCC tissues and increase from (3.30 {+-} 0.09) Multiplication-Sign 10{sup -6} and (1.57 {+-} 0.05) Multiplication-Sign 10{sup -5} cm s{sup -1} at the mucous membrane of normal esophagus and ESCC tissues to (1.82 {+-} 0.04) Multiplication-Sign 10{sup -5} and (3.53 {+-} 0.09) Multiplication-Sign 10{sup -5} cm s{sup -1} at the submucous layer approximately 742 {mu}m away from the epithelial surface of normal esophagus and ESCC tissues, respectively. (optical coherence tomography)

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
22043664
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 41; Journal Issue: 10; Other Information: Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; AMPLITUDES; ANIMAL TISSUES; BIOPHYSICS; CARCINOMAS; DIFFUSION; ESOPHAGUS; GLUCOSE; IMAGES; IN VITRO; LAYERS; MUCOUS MEMBRANES; PERMEABILITY; SURFACES; TOMOGRAPHY

Citation Formats

Qingliang, Zhao, Zhouyi, Guo, Huajiang, Wei, Hongqin, Yang, and Shusen, Xie. Depth-resolved monitoring of diffusion of hyperosmotic agents in normal and malignant human esophagus tissues using optical coherence tomography in-vitro. United States: N. p., 2011. Web. doi:10.1070/QE2011V041N10ABEH014549.
Qingliang, Zhao, Zhouyi, Guo, Huajiang, Wei, Hongqin, Yang, & Shusen, Xie. Depth-resolved monitoring of diffusion of hyperosmotic agents in normal and malignant human esophagus tissues using optical coherence tomography in-vitro. United States. https://doi.org/10.1070/QE2011V041N10ABEH014549
Qingliang, Zhao, Zhouyi, Guo, Huajiang, Wei, Hongqin, Yang, and Shusen, Xie. 2011. "Depth-resolved monitoring of diffusion of hyperosmotic agents in normal and malignant human esophagus tissues using optical coherence tomography in-vitro". United States. https://doi.org/10.1070/QE2011V041N10ABEH014549.
@article{osti_22043664,
title = {Depth-resolved monitoring of diffusion of hyperosmotic agents in normal and malignant human esophagus tissues using optical coherence tomography in-vitro},
author = {Qingliang, Zhao and Zhouyi, Guo and Huajiang, Wei and Hongqin, Yang and Shusen, Xie},
abstractNote = {Depth-resolved monitoring with differentiation and quantification of glucose diffusion in healthy and abnormal esophagus tissues has been studied in vitro. Experiments have been performed using human normal esophagus and esophageal squamous cell carcinoma (ESCC) tissues by the optical coherence tomography (OCT). The images have been continuously acquired for 120 min in the experiments, and the depth-resolved and average permeability coefficients of the 40 % glucose solution have been calculated by the OCT amplitude (OCTA) method. We demonstrate the capability of the OCT technique for depth-resolved monitoring, differentiation, and quantifying of glucose diffusion in normal esophagus and ESCC tissues. It is found that the permeability coefficients of the 40 % glucose solution are not uniform throughout the normal esophagus and ESCC tissues and increase from (3.30 {+-} 0.09) Multiplication-Sign 10{sup -6} and (1.57 {+-} 0.05) Multiplication-Sign 10{sup -5} cm s{sup -1} at the mucous membrane of normal esophagus and ESCC tissues to (1.82 {+-} 0.04) Multiplication-Sign 10{sup -5} and (3.53 {+-} 0.09) Multiplication-Sign 10{sup -5} cm s{sup -1} at the submucous layer approximately 742 {mu}m away from the epithelial surface of normal esophagus and ESCC tissues, respectively. (optical coherence tomography)},
doi = {10.1070/QE2011V041N10ABEH014549},
url = {https://www.osti.gov/biblio/22043664}, journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 10,
volume = 41,
place = {United States},
year = {Mon Oct 31 00:00:00 EDT 2011},
month = {Mon Oct 31 00:00:00 EDT 2011}
}