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Title: Diffusion dynamics of small molecules from mesoporous silicon films by real-time optical interferometry

Abstract

Time-dependent laser reflectometry measurements are presented as a means to rigorously characterize analyte diffusion dynamics of small molecules from mesoporous silicon (PSi) films for drug delivery and membrane physics applications. Calculations based on inclusion of a spatially and temporally dependent solute concentration profile in a one-dimensional Fickian diffusion flow model are performed to determine the diffusion coefficients for the selected prototypical polar species, sucrose (340 Da), exiting from PSi films. The diffusion properties of the molecules depend on both PSi pore size and film thickness. For films with average pore diameters between 10-30 nm and film thicknesses between 300-900 nm, the sucrose diffusion coefficient can be tuned between approximately 100 and 550 {mu}m{sup 2}/s. Extensions of the real-time measurement and modeling approach for determining the diffusivity of small molecules that strongly interact with and corrode the internal surfaces of PSi films are also discussed.

Authors:
;
Publication Date:
OSTI Identifier:
22036722
Resource Type:
Journal Article
Journal Name:
Applied Optics
Additional Journal Information:
Journal Volume: 50; Journal Issue: 27; Other Information: (c) 2011 Optical Society of America; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0003-6935
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; DIFFUSION; FILMS; FLOW MODELS; INCLUSIONS; INTERFEROMETRY; LASER RADIATION; MEMBRANES; MOLECULES; NANOSTRUCTURES; ONE-DIMENSIONAL CALCULATIONS; SACCHAROSE; SILICON; SIMULATION; SURFACES; THICKNESS; TIME DEPENDENCE; TIME MEASUREMENT

Citation Formats

Mares, Jeremy W., and Weiss, Sharon M. Diffusion dynamics of small molecules from mesoporous silicon films by real-time optical interferometry. United States: N. p., 2011. Web. doi:10.1364/AO.50.005329.
Mares, Jeremy W., & Weiss, Sharon M. Diffusion dynamics of small molecules from mesoporous silicon films by real-time optical interferometry. United States. doi:10.1364/AO.50.005329.
Mares, Jeremy W., and Weiss, Sharon M. Tue . "Diffusion dynamics of small molecules from mesoporous silicon films by real-time optical interferometry". United States. doi:10.1364/AO.50.005329.
@article{osti_22036722,
title = {Diffusion dynamics of small molecules from mesoporous silicon films by real-time optical interferometry},
author = {Mares, Jeremy W. and Weiss, Sharon M.},
abstractNote = {Time-dependent laser reflectometry measurements are presented as a means to rigorously characterize analyte diffusion dynamics of small molecules from mesoporous silicon (PSi) films for drug delivery and membrane physics applications. Calculations based on inclusion of a spatially and temporally dependent solute concentration profile in a one-dimensional Fickian diffusion flow model are performed to determine the diffusion coefficients for the selected prototypical polar species, sucrose (340 Da), exiting from PSi films. The diffusion properties of the molecules depend on both PSi pore size and film thickness. For films with average pore diameters between 10-30 nm and film thicknesses between 300-900 nm, the sucrose diffusion coefficient can be tuned between approximately 100 and 550 {mu}m{sup 2}/s. Extensions of the real-time measurement and modeling approach for determining the diffusivity of small molecules that strongly interact with and corrode the internal surfaces of PSi films are also discussed.},
doi = {10.1364/AO.50.005329},
journal = {Applied Optics},
issn = {0003-6935},
number = 27,
volume = 50,
place = {United States},
year = {2011},
month = {9}
}