Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma

Journal Article · Mon Mar 12 00:00:00 EDT 2012 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.3694928· OSTI ID:22025470

Iseki, Sachiko; Tanaka, Hiromasa; Kondo, Hiroki; Hori, Masaru ^[1]; Nakamura, Kae; Hayashi, Moemi; Kajiyama, Hiroaki; Kikkawa, Fumitaka ^[2]; Kano, Hiroyuki ^[3]

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1. Department of Electrical Engineering and Computer Science, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan)
2. Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550 (Japan)
3. NU Eco-Engineering Co., Ltd., 1237-87 Umazutsumi, Kurozasa-cho, Miyoshi-shi, Nishikamo-gun, Aichi 470-0201 (Japan)

Two independent ovarian cancer cell lines and fibroblast controls were treated with nonequilibrium atmospheric pressure plasma (NEAPP). Most ovarian cancer cells were detached from the culture dish by continuous plasma treatment to a single spot on the dish. Next, the plasma source was applied over the whole dish using a robot arm. In vitro cell proliferation assays showed that plasma treatments significantly decreased proliferation rates of ovarian cancer cells compared to fibroblast cells. Flow cytometry and western blot analysis showed that plasma treatment of ovarian cancer cells induced apoptosis. NEAPP could be a promising tool for therapy for ovarian cancers.

• OSTI ID: 22025470
• Journal Information: Applied Physics Letters, Vol. 100, Issue 11; Other Information: (c) 2012 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
ATMOSPHERIC PRESSURE
BIOPHYSICS
CELL PROLIFERATION
FIBROBLASTS
IN VITRO
INDUCTION
NEOPLASMS
PATIENTS
PLASMA
THERAPY