skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts

Abstract

Purpose: This study was designed to clarify the advantages of biodegradable stents in terms of mucosal reaction and biodegradation after placement. We designed a biodegradable stent and assessed stent degradation and changes in the normal bile ducts of dogs. Methods: The biodegradable stent is a balloon-expandable Z stent consisting of poly-l-lactic acid (PLLA) with a diameter of 6 mm and a length of 15 mm. We assessed four groups of three beagle dogs each at 1, 3, 6, and 9 months of follow-up. After evaluating stent migration by radiography and stent and bile duct patency by cholangiography, the dogs were sacrificed to remove the bile duct together with the stent. The bile duct lumen was examined macroscopically and histologically, and the stent degradation was examined macroscopically and by scanning electron microscopy (SEM). Results: Bile duct obstruction was absent and none of the stents migrated. Macroscopic evaluation showed moderate endothelial proliferation in the bile ducts at the implant sites at 3 and 6 months and a slight change at 9 months. Slight mononuclear cell infiltration was histologically identified at all time points and epithelial hyperplasia that was moderate at 3 months was reduced to slight at 6 and 9 months. Stentmore » degradation was macroscopically evident in all animals at 9 months and was proven by SEM in two dogs at 6 months and in all of them at 9 months. Conclusions: Our results suggest that PLLA bioabsorbable stents seems to be useful for implantation in the biliary system with further investigation.« less

Authors:
; ; ; ; ; ;  [1];  [2];  [1]
  1. Nara Medical University, Department of Radiology (Japan)
  2. Daiyukai General Hospital, Department of Radiology (Japan)
Publication Date:
OSTI Identifier:
21608699
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 34; Journal Issue: 3; Conference: CIRSE 2011: Annual meeting of the Cardiovascular and Interventional Radiological Society of Europe, Munich (Germany), 10-14 Sep 2011; Other Information: DOI: 10.1007/s00270-010-0045-2; Copyright (c) 2011 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEAGLES; BILIARY TRACT; BIODEGRADATION; EVALUATION; HISTOLOGY; SCANNING ELECTRON MICROSCOPY; ANIMALS; CHEMICAL REACTIONS; DECOMPOSITION; DIGESTIVE SYSTEM; DOGS; ELECTRON MICROSCOPY; MAMMALS; MICROSCOPY; VERTEBRATES

Citation Formats

Yamamoto, Kiyosei, E-mail: yamakiyo@zg7.so-net.ne.jp, Yoshioka, Tetsuya, Furuichi, Kinya, Sakaguchi, Hiroshi, Anai, Hiroshi, Tanaka, Toshihiro, Morimoto, Kengo, Uchida, Hideo, and Kichikawa, Kimihiko. Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts. United States: N. p., 2011. Web. doi:10.1007/S00270-010-0045-2.
Yamamoto, Kiyosei, E-mail: yamakiyo@zg7.so-net.ne.jp, Yoshioka, Tetsuya, Furuichi, Kinya, Sakaguchi, Hiroshi, Anai, Hiroshi, Tanaka, Toshihiro, Morimoto, Kengo, Uchida, Hideo, & Kichikawa, Kimihiko. Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts. United States. doi:10.1007/S00270-010-0045-2.
Yamamoto, Kiyosei, E-mail: yamakiyo@zg7.so-net.ne.jp, Yoshioka, Tetsuya, Furuichi, Kinya, Sakaguchi, Hiroshi, Anai, Hiroshi, Tanaka, Toshihiro, Morimoto, Kengo, Uchida, Hideo, and Kichikawa, Kimihiko. Wed . "Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts". United States. doi:10.1007/S00270-010-0045-2.
@article{osti_21608699,
title = {Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts},
author = {Yamamoto, Kiyosei, E-mail: yamakiyo@zg7.so-net.ne.jp and Yoshioka, Tetsuya and Furuichi, Kinya and Sakaguchi, Hiroshi and Anai, Hiroshi and Tanaka, Toshihiro and Morimoto, Kengo and Uchida, Hideo and Kichikawa, Kimihiko},
abstractNote = {Purpose: This study was designed to clarify the advantages of biodegradable stents in terms of mucosal reaction and biodegradation after placement. We designed a biodegradable stent and assessed stent degradation and changes in the normal bile ducts of dogs. Methods: The biodegradable stent is a balloon-expandable Z stent consisting of poly-l-lactic acid (PLLA) with a diameter of 6 mm and a length of 15 mm. We assessed four groups of three beagle dogs each at 1, 3, 6, and 9 months of follow-up. After evaluating stent migration by radiography and stent and bile duct patency by cholangiography, the dogs were sacrificed to remove the bile duct together with the stent. The bile duct lumen was examined macroscopically and histologically, and the stent degradation was examined macroscopically and by scanning electron microscopy (SEM). Results: Bile duct obstruction was absent and none of the stents migrated. Macroscopic evaluation showed moderate endothelial proliferation in the bile ducts at the implant sites at 3 and 6 months and a slight change at 9 months. Slight mononuclear cell infiltration was histologically identified at all time points and epithelial hyperplasia that was moderate at 3 months was reduced to slight at 6 and 9 months. Stent degradation was macroscopically evident in all animals at 9 months and was proven by SEM in two dogs at 6 months and in all of them at 9 months. Conclusions: Our results suggest that PLLA bioabsorbable stents seems to be useful for implantation in the biliary system with further investigation.},
doi = {10.1007/S00270-010-0045-2},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 34,
place = {United States},
year = {2011},
month = {6}
}