skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients

Abstract

Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 {+-} 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P < 0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P < 0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P < 0.001). The majority of patients (70 of 81; 86%) did not use an externalmore » brace after PV (P < 0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.« less

Authors:
 [1];  [2];  [3];  [1]; ; ; ;  [4];  [1];  [5]
  1. Institute for Cancer Research and Treatment, Interventional Radiology Unit (Italy)
  2. Institute for Cancer Research and Treatment, Oncology Unit (Italy)
  3. Massachusetts General Hospital, Interventional Neuroradiology (United States)
  4. Institute for Cancer Research and Treatment, Anesthesiology Unit (Italy)
  5. Institute for Cancer Research and Treatment, Radiology Unit (Italy)
Publication Date:
OSTI Identifier:
21608634
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 35; Journal Issue: 1; Other Information: DOI: 10.1007/s00270-011-0111-4; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANALGESICS; CEMENTS; FRACTURES; INJECTION; METASTASES; OSTEOPOROSIS; PAIN; PATIENTS; SAFETY; SKELETON; THERAPY; BODY; BUILDING MATERIALS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASES; DRUGS; FAILURES; INTAKE; MATERIALS; MEDICINE; ORGANS; SKELETAL DISEASES; SYMPTOMS

Citation Formats

Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it, Manca, Antonio, Montemurro, Filippo, Hirsch, Joshua, Chiara, Gabriele, Grignani, Giovanni, Carnevale Schianca, Fabrizio, E-mail: fabrizio.carnevale@ircc.it, Capaldi, Antonio, Rota Scalabrini, Delia, E-mail: delia.rotascalabrini@ircc.it, Sardo, Elena, Debernardi, Felicino, Iussich, Gabriella, and Regge, Daniele. Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients. United States: N. p., 2012. Web. doi:10.1007/S00270-011-0111-4.
Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it, Manca, Antonio, Montemurro, Filippo, Hirsch, Joshua, Chiara, Gabriele, Grignani, Giovanni, Carnevale Schianca, Fabrizio, E-mail: fabrizio.carnevale@ircc.it, Capaldi, Antonio, Rota Scalabrini, Delia, E-mail: delia.rotascalabrini@ircc.it, Sardo, Elena, Debernardi, Felicino, Iussich, Gabriella, & Regge, Daniele. Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients. United States. https://doi.org/10.1007/S00270-011-0111-4
Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it, Manca, Antonio, Montemurro, Filippo, Hirsch, Joshua, Chiara, Gabriele, Grignani, Giovanni, Carnevale Schianca, Fabrizio, E-mail: fabrizio.carnevale@ircc.it, Capaldi, Antonio, Rota Scalabrini, Delia, E-mail: delia.rotascalabrini@ircc.it, Sardo, Elena, Debernardi, Felicino, Iussich, Gabriella, and Regge, Daniele. 2012. "Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients". United States. https://doi.org/10.1007/S00270-011-0111-4.
@article{osti_21608634,
title = {Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients},
author = {Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it and Manca, Antonio and Montemurro, Filippo and Hirsch, Joshua and Chiara, Gabriele and Grignani, Giovanni and Carnevale Schianca, Fabrizio, E-mail: fabrizio.carnevale@ircc.it and Capaldi, Antonio and Rota Scalabrini, Delia, E-mail: delia.rotascalabrini@ircc.it and Sardo, Elena and Debernardi, Felicino and Iussich, Gabriella and Regge, Daniele},
abstractNote = {Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 {+-} 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P < 0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P < 0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P < 0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P < 0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.},
doi = {10.1007/S00270-011-0111-4},
url = {https://www.osti.gov/biblio/21608634}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 1,
volume = 35,
place = {United States},
year = {Wed Feb 15 00:00:00 EST 2012},
month = {Wed Feb 15 00:00:00 EST 2012}
}