Successful Thrombolysis and Spasmolysis of Acute Leg Ischemia after Accidental Intra-arterial Injection of Dissolved Flunitrazepam Tablets

Journal Article · Sat Oct 15 00:00:00 EDT 2011 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-011-0173-3· OSTI ID:21608591

Radeleff, B; Stampfl, U; Sommer, C -M; Bellemann, N ^[1]; Hyhlik-Duerr, A ^[2]; Weber, M -A ^[1]; Boeckler, D ^[2]; Kauczor, H -U ^[1]

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1. University of Heidelberg, Diagnostic and Interventional Radiology (Germany)
2. University of Heidelberg, Department of Vascular and Endovascular Surgery (Germany)

A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery. A combination of anticoagulation, vasodilatation, and local selective and superselective thrombolysis with urokinase was performed to salvage the leg. As a result of the severe ischemia-induced pain, the patient had to be monitored over the complete therapy period on the intensive care unit with permanent administration of intravenous fluid and analgetics. We describe the presenting symptoms and the interventional technique, and we discuss the recent literature regarding the management of accidental intra-arterial injection of dissolved flunitrazepam tablets.

• OSTI ID: 21608591
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 34, Issue 5; Other Information: DOI: 10.1007/s00270-011-0173-3; Copyright (c) 2011 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
DRUG ABUSE
FLUIDS
INJECTION
ISCHEMIA
LEGS
MAN
PAIN
PATIENTS
SURGERY
THERAPY
UROKINASE
VASODILATION
ANEMIAS
ANIMALS
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ENZYMES
FIBRINOLYTIC AGENTS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HYDROLASES
INTAKE
LIMBS
MAMMALS
MEDICINE
NONSPECIFIC PEPTIDASES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PRIMATES
PROTEINS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES