Liver Hypertrophy After Percutaneous Portal Vein Embolization: Comparison of N-Butyl-2-Cyanocrylate Versus Sodium Acrylate-Vinyl Alcohol Copolymer Particles in a Swine Model

Journal Article · Sat Oct 15 00:00:00 EDT 2011 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-010-0046-1· OSTI ID:21608584

Tsoumakidou, Georgia ^[1]; Theocharis, Stamatis ^[2]; Ptohis, Nikolaos; Alexopoulou, Efthimia ^[1]; Mantziaras, George ^[3]

---

1. National and Kapodistrian University of Athens, 2nd Department of Radiology, Medical School, General University Hospital Attikon (Greece)
2. National and Kapodistrian University of Athens, Department of Forensic Medicine and Toxicology, Medical School (Greece)
3. Academy of Athens, Biomedical Research Foundation (Greece)

Purpose: Percutaneous portal vein embolization (PPVE) induces hypertrophy of the future liver remnant before hepatic resection. The ideal embolic material has not yet been determined. We compared N-butyl-2-cyanocrylate (NBCA) with sodium acrylate-vinyl alcohol copolymer particles using a swine model. Materials and Methods: Twelve pigs underwent PPVE. Six pigs (group A) were embolized with NBCA, and 6 pigs (group B) were embolized with sodium acrylate-vinyl alcohol copolymer particles. Computed tomographic volumetry of the embolized lobe (EL) and the nonembolized lobe (NEL), along with liver function tests, was performed before and at 14 and 28 days after embolization. Tissue samples from both lobes were taken 14 and 28 days after PPVE. Results: NEL-volume and NEL-ratio increases were significantly higher in group A at 14 and 28 days after PPVE (78 and 52% and 91 and 66%, respectively) than in group B (32 and 12% and 28 and 10%, respectively) (p < 0.05). Percent change of the EL-volume was significantly higher for group A at 28 days after PPVE. No statistically significant difference was found between the groups regarding hepatocyte proliferation on the NEL and apoptosis on the EL at both time intervals. Conclusion: PPVE using NBCA is more efficient and causes more NEL hypertrophy than microspheres.

• OSTI ID: 21608584
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 34, Issue 5; Other Information: DOI: 10.1007/s00270-010-0046-1; Copyright (c) 2011 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACRYLATES
APOPTOSIS
COPOLYMERS
HYPERTROPHY
LIVER
MATERIALS
PARTICLES
SWINE
VEINS
ANIMALS
BLOOD VESSELS
BODY
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
GLANDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PATHOLOGICAL CHANGES
POLYMERS
VERTEBRATES