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Title: A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate

Abstract

The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement wouldmore » permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.« less

Authors:
; ;  [1];  [2];  [1]; ;  [2];  [1]
  1. University Charite, Center for Musculoskeletal Surgery (Germany)
  2. University Charite, Department of Radiology (Germany)
Publication Date:
OSTI Identifier:
21608533
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 35; Journal Issue: 3; Other Information: DOI: 10.1007/s00270-011-0192-0; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; APATITES; CEMENTS; DOSES; IMAGES; INJECTION; NMR IMAGING; PMMA; PULSES; SIGNALS; SIMULATION; SPIN ECHO; SURGERY; VERTEBRAE; BODY; BUILDING MATERIALS; DIAGNOSTIC TECHNIQUES; ESTERS; INTAKE; MATERIALS; MEDICINE; MINERALS; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANS; PHOSPHATE MINERALS; POLYACRYLATES; POLYMERS; POLYVINYLS; SKELETON

Citation Formats

Wichlas, Florian, E-mail: florian.wichlas@charite.de, Seebauer, Christian J., Schilling, Rene, Rump, Jens, Chopra, Sascha S., Walter, Thula, Teichgraeber, Ulf K. M., and Bail, Hermann J. A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate. United States: N. p., 2012. Web. doi:10.1007/S00270-011-0192-0.
Wichlas, Florian, E-mail: florian.wichlas@charite.de, Seebauer, Christian J., Schilling, Rene, Rump, Jens, Chopra, Sascha S., Walter, Thula, Teichgraeber, Ulf K. M., & Bail, Hermann J. A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate. United States. doi:10.1007/S00270-011-0192-0.
Wichlas, Florian, E-mail: florian.wichlas@charite.de, Seebauer, Christian J., Schilling, Rene, Rump, Jens, Chopra, Sascha S., Walter, Thula, Teichgraeber, Ulf K. M., and Bail, Hermann J. Fri . "A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate". United States. doi:10.1007/S00270-011-0192-0.
@article{osti_21608533,
title = {A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate},
author = {Wichlas, Florian, E-mail: florian.wichlas@charite.de and Seebauer, Christian J. and Schilling, Rene and Rump, Jens and Chopra, Sascha S. and Walter, Thula and Teichgraeber, Ulf K. M. and Bail, Hermann J.},
abstractNote = {The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement would permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.},
doi = {10.1007/S00270-011-0192-0},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 35,
place = {United States},
year = {2012},
month = {6}
}