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Title: A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs

Abstract

Objective: This study was designed to establish guinea pigs as an animal model for uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM). Methods: Twenty-five female adult guinea pigs were randomly divided into two groups, including a uterine artery casting mould group (n = 10) and a UAE group (n = 15). Pelvic angiography and vascular casting mould were performed in the first group. The anatomical characters of the pelvic cavity in guinea pigs were described. In the second group, the technical feasibility of performing UAE with TAGM in guinea pigs was investigated. The histopathological slides of the uterus of guinea pigs after UAE were examined to inspect the outcomes of UAE. Results: The uterine artery springs from the internal iliac artery, ascends tortuously along the cervix, and gives off vertically 8-10 branches to the cervix uteri and uterine horns. The diameters of the trunk of the uterine artery and its first branch were 0.32 {+-} 0.027 mm and 0.14 {+-} 0.01 mm, respectively. For UAE animals, the dosages of 40-120 and 100-300 {mu}m TAGM were 0.033 {+-} 0.003 ml and 0.015 {+-} 0.002 ml, respectively. On histopathological slides, embosphere particles were found in the first branches of the uterinemore » artery, the subserous arteries, and the intramural arteries. Inflammatory reactions in the uterus were common in guinea pigs after UAE. Local or dispersed areas of necrosis in uterus also were observed in a few guinea pigs. Conclusions: Guinea pigs are an appropriate and feasible model for UAE with TAGM.« less

Authors:
; ;  [1];  [2]
  1. The First Affiliated Hospital of Sun Yat-sen University, Department of Interventional Radiology (China)
  2. The First Affiliated Hospital of Sun Yat-sen University, Department of Radiology (China)
Publication Date:
OSTI Identifier:
21608527
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 35; Journal Issue: 3; Other Information: DOI: 10.1007/s00270-011-0215-x; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADULTS; ARTERIES; BIOMEDICAL RADIOGRAPHY; CASTING MOLDS; FEMALES; GELATIN; GUINEA PIGS; INFLAMMATION; MICROSPHERES; NECROSIS; SWINE; UTERUS; AGE GROUPS; ANIMALS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; COLLOIDS; DIAGNOSTIC TECHNIQUES; DISPERSIONS; DOMESTIC ANIMALS; FEMALE GENITALS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; RADIOLOGY; RODENTS; SYMPTOMS; VERTEBRATES

Citation Formats

Zhuang Wenquan, Tan Guosheng, Guo Wenbo, E-mail: patrickguo2008@163.com, and Yang Jianyong. A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs. United States: N. p., 2012. Web. doi:10.1007/S00270-011-0215-X.
Zhuang Wenquan, Tan Guosheng, Guo Wenbo, E-mail: patrickguo2008@163.com, & Yang Jianyong. A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs. United States. doi:10.1007/S00270-011-0215-X.
Zhuang Wenquan, Tan Guosheng, Guo Wenbo, E-mail: patrickguo2008@163.com, and Yang Jianyong. Fri . "A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs". United States. doi:10.1007/S00270-011-0215-X.
@article{osti_21608527,
title = {A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs},
author = {Zhuang Wenquan and Tan Guosheng and Guo Wenbo, E-mail: patrickguo2008@163.com and Yang Jianyong},
abstractNote = {Objective: This study was designed to establish guinea pigs as an animal model for uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM). Methods: Twenty-five female adult guinea pigs were randomly divided into two groups, including a uterine artery casting mould group (n = 10) and a UAE group (n = 15). Pelvic angiography and vascular casting mould were performed in the first group. The anatomical characters of the pelvic cavity in guinea pigs were described. In the second group, the technical feasibility of performing UAE with TAGM in guinea pigs was investigated. The histopathological slides of the uterus of guinea pigs after UAE were examined to inspect the outcomes of UAE. Results: The uterine artery springs from the internal iliac artery, ascends tortuously along the cervix, and gives off vertically 8-10 branches to the cervix uteri and uterine horns. The diameters of the trunk of the uterine artery and its first branch were 0.32 {+-} 0.027 mm and 0.14 {+-} 0.01 mm, respectively. For UAE animals, the dosages of 40-120 and 100-300 {mu}m TAGM were 0.033 {+-} 0.003 ml and 0.015 {+-} 0.002 ml, respectively. On histopathological slides, embosphere particles were found in the first branches of the uterine artery, the subserous arteries, and the intramural arteries. Inflammatory reactions in the uterus were common in guinea pigs after UAE. Local or dispersed areas of necrosis in uterus also were observed in a few guinea pigs. Conclusions: Guinea pigs are an appropriate and feasible model for UAE with TAGM.},
doi = {10.1007/S00270-011-0215-X},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 35,
place = {United States},
year = {2012},
month = {6}
}