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Title: Uterine Artery Embolization versus Myomectomy: Impact on Quality of Life-Results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) Trial

Abstract

Purpose: This study was designed to compare quality of life (QoL) outcomes after uterine artery embolization (UAE) or myomectomy. Methods: Women with symptomatic fibroids diagnosed by ultrasound who wished to preserve their uterus were randomized to myomectomy (n = 81) or UAE (n = 82). Endpoints at 1 year were QoL measured by a validated questionnaire, hospital stay, rates of complications, and need for reintervention. Results: UAE patients had shorter hospitalization (2 vs. 6 days, p < 0.001). By 1 year postintervention, significant and equal improvements in QoL scores had occurred in both groups (myomectomy n = 59; UAE n = 61). There had been two (2.9%) major complications among UAE versus 6 (8%) among myomectomy patients (not significant). By 2 years, among UAE patients (n = 57) there were eight (14.0%) reinterventions for inadequate symptom control compared with one (2.7%) among myomectomy patients (n = 37). Half of the women who required hysterectomy had concomitant adenomyosis missed by US. Conclusions: UAE and myomectomy both result in significant and equal improvements in QoL. UAE allows a shorter hospital stay and fewer major complications but with a higher rate of reintervention.

Authors:
 [1];  [2];  [3]; ;  [1];  [2]
  1. St. George's Hospital, Department of Gynaecology (United Kingdom)
  2. St. George's Hospital, Department of Radiology (United Kingdom)
  3. University of Sussex, School of Psychology (United Kingdom)
Publication Date:
OSTI Identifier:
21608522
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 35; Journal Issue: 3; Other Information: DOI: 10.1007/s00270-011-0228-5; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; CONTROL; PATIENTS; STANDARD OF LIVING; SYMPTOMS; UTERUS; WOMEN; ANIMALS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; FEMALE GENITALS; FEMALES; MAMMALS; MAN; ORGANS; PRIMATES; VERTEBRATES

Citation Formats

Manyonda, Isaac T., E-mail: imanyond@sgul.ac.uk, Bratby, Mark, Horst, Jessica S., Banu, Nassera, Gorti, Maha, and Belli, Anna-Maria. Uterine Artery Embolization versus Myomectomy: Impact on Quality of Life-Results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) Trial. United States: N. p., 2012. Web. doi:10.1007/S00270-011-0228-5.
Manyonda, Isaac T., E-mail: imanyond@sgul.ac.uk, Bratby, Mark, Horst, Jessica S., Banu, Nassera, Gorti, Maha, & Belli, Anna-Maria. Uterine Artery Embolization versus Myomectomy: Impact on Quality of Life-Results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) Trial. United States. doi:10.1007/S00270-011-0228-5.
Manyonda, Isaac T., E-mail: imanyond@sgul.ac.uk, Bratby, Mark, Horst, Jessica S., Banu, Nassera, Gorti, Maha, and Belli, Anna-Maria. Fri . "Uterine Artery Embolization versus Myomectomy: Impact on Quality of Life-Results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) Trial". United States. doi:10.1007/S00270-011-0228-5.
@article{osti_21608522,
title = {Uterine Artery Embolization versus Myomectomy: Impact on Quality of Life-Results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) Trial},
author = {Manyonda, Isaac T., E-mail: imanyond@sgul.ac.uk and Bratby, Mark and Horst, Jessica S. and Banu, Nassera and Gorti, Maha and Belli, Anna-Maria},
abstractNote = {Purpose: This study was designed to compare quality of life (QoL) outcomes after uterine artery embolization (UAE) or myomectomy. Methods: Women with symptomatic fibroids diagnosed by ultrasound who wished to preserve their uterus were randomized to myomectomy (n = 81) or UAE (n = 82). Endpoints at 1 year were QoL measured by a validated questionnaire, hospital stay, rates of complications, and need for reintervention. Results: UAE patients had shorter hospitalization (2 vs. 6 days, p < 0.001). By 1 year postintervention, significant and equal improvements in QoL scores had occurred in both groups (myomectomy n = 59; UAE n = 61). There had been two (2.9%) major complications among UAE versus 6 (8%) among myomectomy patients (not significant). By 2 years, among UAE patients (n = 57) there were eight (14.0%) reinterventions for inadequate symptom control compared with one (2.7%) among myomectomy patients (n = 37). Half of the women who required hysterectomy had concomitant adenomyosis missed by US. Conclusions: UAE and myomectomy both result in significant and equal improvements in QoL. UAE allows a shorter hospital stay and fewer major complications but with a higher rate of reintervention.},
doi = {10.1007/S00270-011-0228-5},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 35,
place = {United States},
year = {2012},
month = {6}
}