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Title: Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q{sub 10} pretreatment

Abstract

Numerous epidemiological studies have shown an association between pesticide exposure and increased risk of developing Parkinson's diseases. Oxidative stress generated as a result of mitochondrial dysfunction has been implicated as an important factor in the etiology of Parkinson's disease. Previously, we reported that chronic dichlorvos exposure causes mitochondrial impairments and nigrostriatal neuronal death in rats. The present study was designed to test whether Coenzyme Q{sub 10} (CoQ{sub 10}) administration has any neuroprotective effect against dichlorvos mediated nigrostriatal neuronal death, {alpha}-synuclein aggregation, and motor dysfunction. Male albino rats were administered dichlorvos by subcutaneous injection at a dose of 2.5 mg/kg body weight over a period of 12 weeks. Results obtained there after showed that dichlorvos exposure leads to enhanced mitochondrial ROS production, {alpha}-synuclein aggregation, decreased dopamine and its metabolite levels resulting in nigrostriatal neurodegeneration. Pretreatment by Coenzyme Q{sub 10} (4.5 mg/kg ip for 12 weeks) to dichlorvos treated animals significantly attenuated the extent of nigrostriatal neuronal damage, in terms of decreased ROS production, increased dopamine and its metabolite levels, and restoration of motor dysfunction when compared to dichlorvos treated animals. Thus, the present study shows that Coenzyme Q{sub 10} administration may attenuate dichlorvos induced nigrostriatal neurodegeneration, {alpha}-synuclein aggregation and motor dysfunctionmore » by virtue of its antioxidant action. - Highlights: > CoQ{sub 10} administration attenuates dichlorvos induced nigrostriatal neurodegenaration. > CoQ{sub 10} pre treatment leads to preservation of TH-IR neurons. > CoQ{sub 10} may decrease oxidative damage and {alpha}-synuclin aggregation. > CoQ{sub 10} treatment enhances motor function and protects rats from catalepsy.« less

Authors:
;  [1];  [2];  [1]
  1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 (India)
  2. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh (India)
Publication Date:
OSTI Identifier:
21587851
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 256; Journal Issue: 1; Other Information: DOI: 10.1016/j.taap.2011.07.015; PII: S0041-008X(11)00284-5; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AGGLOMERATION; COENZYMES; DOPAMINE; ETIOLOGY; HYDROXYLASES; MALES; MITOCHONDRIA; NERVE CELLS; NERVOUS SYSTEM DISEASES; OXIDATION; OXYGEN; SAFETY; STRESSES; SUBCUTANEOUS INJECTION; TYROSINE; AMINES; AMINO ACIDS; ANIMAL CELLS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; CARBOXYLIC ACIDS; CARDIOTONICS; CARDIOVASCULAR AGENTS; CELL CONSTITUENTS; CHEMICAL REACTIONS; DISEASES; DRUGS; ELEMENTS; ENZYMES; HYDROXY ACIDS; HYDROXY COMPOUNDS; INJECTION; INTAKE; NEUROREGULATORS; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXIDOREDUCTASES; PHENOLS; POLYPHENOLS; PROTEINS; SOMATIC CELLS; SYMPATHOMIMETICS

Citation Formats

Binukumar, BK, Gupta, Nidhi, Bal, Amanjit, and Gill, Kiran Dip, E-mail: kdgill2002@yahoo.co.in. Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q{sub 10} pretreatment. United States: N. p., 2011. Web. doi:10.1016/j.taap.2011.07.015.
Binukumar, BK, Gupta, Nidhi, Bal, Amanjit, & Gill, Kiran Dip, E-mail: kdgill2002@yahoo.co.in. Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q{sub 10} pretreatment. United States. doi:10.1016/j.taap.2011.07.015.
Binukumar, BK, Gupta, Nidhi, Bal, Amanjit, and Gill, Kiran Dip, E-mail: kdgill2002@yahoo.co.in. Sat . "Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q{sub 10} pretreatment". United States. doi:10.1016/j.taap.2011.07.015.
@article{osti_21587851,
title = {Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q{sub 10} pretreatment},
author = {Binukumar, BK and Gupta, Nidhi and Bal, Amanjit and Gill, Kiran Dip, E-mail: kdgill2002@yahoo.co.in},
abstractNote = {Numerous epidemiological studies have shown an association between pesticide exposure and increased risk of developing Parkinson's diseases. Oxidative stress generated as a result of mitochondrial dysfunction has been implicated as an important factor in the etiology of Parkinson's disease. Previously, we reported that chronic dichlorvos exposure causes mitochondrial impairments and nigrostriatal neuronal death in rats. The present study was designed to test whether Coenzyme Q{sub 10} (CoQ{sub 10}) administration has any neuroprotective effect against dichlorvos mediated nigrostriatal neuronal death, {alpha}-synuclein aggregation, and motor dysfunction. Male albino rats were administered dichlorvos by subcutaneous injection at a dose of 2.5 mg/kg body weight over a period of 12 weeks. Results obtained there after showed that dichlorvos exposure leads to enhanced mitochondrial ROS production, {alpha}-synuclein aggregation, decreased dopamine and its metabolite levels resulting in nigrostriatal neurodegeneration. Pretreatment by Coenzyme Q{sub 10} (4.5 mg/kg ip for 12 weeks) to dichlorvos treated animals significantly attenuated the extent of nigrostriatal neuronal damage, in terms of decreased ROS production, increased dopamine and its metabolite levels, and restoration of motor dysfunction when compared to dichlorvos treated animals. Thus, the present study shows that Coenzyme Q{sub 10} administration may attenuate dichlorvos induced nigrostriatal neurodegeneration, {alpha}-synuclein aggregation and motor dysfunction by virtue of its antioxidant action. - Highlights: > CoQ{sub 10} administration attenuates dichlorvos induced nigrostriatal neurodegenaration. > CoQ{sub 10} pre treatment leads to preservation of TH-IR neurons. > CoQ{sub 10} may decrease oxidative damage and {alpha}-synuclin aggregation. > CoQ{sub 10} treatment enhances motor function and protects rats from catalepsy.},
doi = {10.1016/j.taap.2011.07.015},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 1,
volume = 256,
place = {United States},
year = {2011},
month = {10}
}