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Title: The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats

Abstract

The debate on tungsten (W) is fostered by its continuous usage in military munitions. Reports demonstrate W solubilizes in soil and can migrate into drinking water supplies and, therefore, is a potential health risk to humans. This study evaluated the reproductive, systemic and neurobehavioral effects of sodium tungstate (NaW) in rats following 70 days of daily pre-and postnatal exposure via oral gavage to 5, 62.5 and 125 mg/kg/day of NaW through mating, gestation and weaning (PND 0-20). Daily administration of NaW produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development. Distress vocalizations were elevated in F{sub 1} offspring from the high dose group, whereas righting reflex showed unexpected sex differences where males demonstrated faster righting than females; however, the effects were not dose-dependent. Locomotor activity was affected in both low and high-dose groups of F{sub 1} females. Low-dose group showed increased distance traveled, more time in ambulatory movements and less time in stereotypic behavior than controls or high dose animals. The high-dose group had more time in stereotypical movements than controls, and less time resting than controls and the lowest exposure group. Maternal retrieval was not affected by NaW exposure. Tungstenmore » analysis showed a systemic distribution of NaW in both parents and offspring, with preferential uptake within the immune organs, including the femur, spleen and thymus. Histopathological evidence suggested no severe chronic injury or loss of function in these organs. However, the heart showed histological lesions, histiocytic inflammation from minimal to mild with cardiomyocyte degeneration and necrosis in several P{sub 0} animals of 125 mg NaW dose group. The result of this study suggests that pre and postnatal exposure to NaW may produce subtle neurobehavioral effects in offspring related to motor activity and emotionality.« less

Authors:
 [1];  [2];  [3];  [4];  [1];  [1]
  1. Naval Medical Research Unit at Dayton (NAMRU), Wright Patterson Air Force Base, OH (United States)
  2. Two Steps Forward, LLC, Sun Prairie, WI (United States)
  3. U.S. Naval Academy, 572M Holloway Road, Annapolis, MD (United States)
  4. Navy Drug Screening Laboratory P.O. Box 113, Naval Air Station Jacksonville, FL (United States)
Publication Date:
OSTI Identifier:
21587790
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 254; Journal Issue: 2; Conference: TRAC 2008/2009 meeting: 2008 Toxicology and Risk Assessment Conference;2009 Toxicology and Risk Assessment Conference, West Chester, OH (United States);West Chester, OH (United States), 14-17 Apr 2008;27-30 Apr 2009; Other Information: DOI: 10.1016/j.taap.2010.04.021; PII: S0041-008X(11)00044-5; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CONTROL; DOSES; DRINKING WATER; FEMALES; FEMUR; HEALTH HAZARDS; HEART; INFLAMMATION; MALES; MILITARY EQUIPMENT; PROGENY; RATS; SEX; SODIUM; SPLEEN; THYMUS; TUNGSTATES; TUNGSTEN; ALKALI METALS; ANIMALS; BODY; CARDIOVASCULAR SYSTEM; ELEMENTS; EQUIPMENT; HAZARDS; HYDROGEN COMPOUNDS; LYMPHATIC SYSTEM; MAMMALS; METALS; ORGANS; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; REFRACTORY METAL COMPOUNDS; REFRACTORY METALS; RODENTS; SKELETON; SYMPTOMS; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; TUNGSTEN COMPOUNDS; VERTEBRATES; WATER

Citation Formats

McInturf, S.M., Bekkedal, M.Y.V., Wilfong, E., Arfsten, D., Chapman, G., and Gunasekar, P.G., E-mail: palur.gunasekar@wpafb.af.mil. The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats. United States: N. p., 2011. Web. doi:10.1016/j.taap.2010.04.021.
McInturf, S.M., Bekkedal, M.Y.V., Wilfong, E., Arfsten, D., Chapman, G., & Gunasekar, P.G., E-mail: palur.gunasekar@wpafb.af.mil. The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats. United States. doi:10.1016/j.taap.2010.04.021.
McInturf, S.M., Bekkedal, M.Y.V., Wilfong, E., Arfsten, D., Chapman, G., and Gunasekar, P.G., E-mail: palur.gunasekar@wpafb.af.mil. Fri . "The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats". United States. doi:10.1016/j.taap.2010.04.021.
@article{osti_21587790,
title = {The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats},
author = {McInturf, S.M. and Bekkedal, M.Y.V. and Wilfong, E. and Arfsten, D. and Chapman, G. and Gunasekar, P.G., E-mail: palur.gunasekar@wpafb.af.mil},
abstractNote = {The debate on tungsten (W) is fostered by its continuous usage in military munitions. Reports demonstrate W solubilizes in soil and can migrate into drinking water supplies and, therefore, is a potential health risk to humans. This study evaluated the reproductive, systemic and neurobehavioral effects of sodium tungstate (NaW) in rats following 70 days of daily pre-and postnatal exposure via oral gavage to 5, 62.5 and 125 mg/kg/day of NaW through mating, gestation and weaning (PND 0-20). Daily administration of NaW produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development. Distress vocalizations were elevated in F{sub 1} offspring from the high dose group, whereas righting reflex showed unexpected sex differences where males demonstrated faster righting than females; however, the effects were not dose-dependent. Locomotor activity was affected in both low and high-dose groups of F{sub 1} females. Low-dose group showed increased distance traveled, more time in ambulatory movements and less time in stereotypic behavior than controls or high dose animals. The high-dose group had more time in stereotypical movements than controls, and less time resting than controls and the lowest exposure group. Maternal retrieval was not affected by NaW exposure. Tungsten analysis showed a systemic distribution of NaW in both parents and offspring, with preferential uptake within the immune organs, including the femur, spleen and thymus. Histopathological evidence suggested no severe chronic injury or loss of function in these organs. However, the heart showed histological lesions, histiocytic inflammation from minimal to mild with cardiomyocyte degeneration and necrosis in several P{sub 0} animals of 125 mg NaW dose group. The result of this study suggests that pre and postnatal exposure to NaW may produce subtle neurobehavioral effects in offspring related to motor activity and emotionality.},
doi = {10.1016/j.taap.2010.04.021},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,
volume = 254,
place = {United States},
year = {2011},
month = {7}
}