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Title: Radiation Pneumopathy in the Rat After Intravenous Application of {sup 188}Re-Labeled Microspheres

Abstract

Purpose: To determine the dose dependence and kinetics of pneumopathy after systemic administration of rhenium-188 ({sup 188}Re)-labeled microspheres in a rat model. Methods and Materials: {sup 188}Re-microspheres were injected intravenously into adult Wistar rats (n = 54, age, 8 {+-} 2 months). The rats were divided into 6 groups according to the intended absorbed dose in the lung (maximum 60 Gy). Gamma camera scans were used to estimate the individual whole lung doses. One control group (n = 5) received nonlabeled microspheres. The breathing rate was measured before and weekly after the treatment using whole body plethysmography until 24 weeks. An increase in the breathing rate by 20% compared with the individual pretreatment control value was defined as the quantal endpoint for dose-effect analyses. Results: A biphasic increase in the breathing rate was observed. The first impairment of lung function occurred in Weeks 3-6. For late changes, the interval to onset was clearly dose dependent and was 17 weeks (10-30 Gy) and 10 weeks (50-60 Gy), respectively. The incidence of the response was highly dependent on the estimated lung dose. The median effective dose for an early and late response was virtually identical (19.9 {+-} 0.6 Gy and 20.4 {+-}more » 3.1 Gy, respectively). A significant correlation was found between the occurrence of an early and a late effect in the same rat, suggesting a strong consequential component. Conclusions: The effects of radiolabeled microspheres can be studied longitudinally in a rat model, using changes in the breathing rate as the functional, clinically relevant response. The isoeffective doses from the present study using radionuclide administration and those from published investigations of homogeneous external beam radiotherapy are almost similar.« less

Authors:
; ; ;  [1];  [2];  [3];  [4];  [1];  [4];  [3];  [1]
  1. Department of Nuclear Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden (Germany)
  2. Department of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden (Germany)
  3. (Germany)
  4. Experimental Center, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden (Germany)
Publication Date:
OSTI Identifier:
21587746
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 81; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2010.08.025; PII: S0360-3016(10)03071-3; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADULTS; GAMMA CAMERAS; KINETICS; LUNGS; MICROSPHERES; RADIATION DOSES; RADIONUCLIDE ADMINISTRATION; RADIOTHERAPY; RATS; RESPIRATION; RHENIUM 188; AGE GROUPS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CAMERAS; DOSES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; RESPIRATORY SYSTEM; RHENIUM ISOTOPES; RODENTS; THERAPY; VERTEBRATES

Citation Formats

Liepe, Knut, Faulhaber, Diana, Wunderlich, Gerd, Andreeff, Michael, Haase, Michael, Department of Pediatric Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Jung, Roland, Oehme, Liane, Doerr, Wolfgang, Department of Radiotherapy and Radiation Oncology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, and Kotzerke, Joerg, E-mail: joerg.kotzerke@mailbox.tu-dresden.de. Radiation Pneumopathy in the Rat After Intravenous Application of {sup 188}Re-Labeled Microspheres. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.08.025.
Liepe, Knut, Faulhaber, Diana, Wunderlich, Gerd, Andreeff, Michael, Haase, Michael, Department of Pediatric Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Jung, Roland, Oehme, Liane, Doerr, Wolfgang, Department of Radiotherapy and Radiation Oncology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, & Kotzerke, Joerg, E-mail: joerg.kotzerke@mailbox.tu-dresden.de. Radiation Pneumopathy in the Rat After Intravenous Application of {sup 188}Re-Labeled Microspheres. United States. doi:10.1016/j.ijrobp.2010.08.025.
Liepe, Knut, Faulhaber, Diana, Wunderlich, Gerd, Andreeff, Michael, Haase, Michael, Department of Pediatric Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Jung, Roland, Oehme, Liane, Doerr, Wolfgang, Department of Radiotherapy and Radiation Oncology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, and Kotzerke, Joerg, E-mail: joerg.kotzerke@mailbox.tu-dresden.de. Sat . "Radiation Pneumopathy in the Rat After Intravenous Application of {sup 188}Re-Labeled Microspheres". United States. doi:10.1016/j.ijrobp.2010.08.025.
@article{osti_21587746,
title = {Radiation Pneumopathy in the Rat After Intravenous Application of {sup 188}Re-Labeled Microspheres},
author = {Liepe, Knut and Faulhaber, Diana and Wunderlich, Gerd and Andreeff, Michael and Haase, Michael and Department of Pediatric Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden and Jung, Roland and Oehme, Liane and Doerr, Wolfgang and Department of Radiotherapy and Radiation Oncology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden and Kotzerke, Joerg, E-mail: joerg.kotzerke@mailbox.tu-dresden.de},
abstractNote = {Purpose: To determine the dose dependence and kinetics of pneumopathy after systemic administration of rhenium-188 ({sup 188}Re)-labeled microspheres in a rat model. Methods and Materials: {sup 188}Re-microspheres were injected intravenously into adult Wistar rats (n = 54, age, 8 {+-} 2 months). The rats were divided into 6 groups according to the intended absorbed dose in the lung (maximum 60 Gy). Gamma camera scans were used to estimate the individual whole lung doses. One control group (n = 5) received nonlabeled microspheres. The breathing rate was measured before and weekly after the treatment using whole body plethysmography until 24 weeks. An increase in the breathing rate by 20% compared with the individual pretreatment control value was defined as the quantal endpoint for dose-effect analyses. Results: A biphasic increase in the breathing rate was observed. The first impairment of lung function occurred in Weeks 3-6. For late changes, the interval to onset was clearly dose dependent and was 17 weeks (10-30 Gy) and 10 weeks (50-60 Gy), respectively. The incidence of the response was highly dependent on the estimated lung dose. The median effective dose for an early and late response was virtually identical (19.9 {+-} 0.6 Gy and 20.4 {+-} 3.1 Gy, respectively). A significant correlation was found between the occurrence of an early and a late effect in the same rat, suggesting a strong consequential component. Conclusions: The effects of radiolabeled microspheres can be studied longitudinally in a rat model, using changes in the breathing rate as the functional, clinically relevant response. The isoeffective doses from the present study using radionuclide administration and those from published investigations of homogeneous external beam radiotherapy are almost similar.},
doi = {10.1016/j.ijrobp.2010.08.025},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 81,
place = {United States},
year = {2011},
month = {10}
}