skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Pretreatment Apparent Diffusion Coefficient of the Primary Lesion Correlates With Local Failure in Head-and-Neck Cancer Treated With Chemoradiotherapy or Radiotherapy

Abstract

Purpose: This study was performed to evaluate whether the apparent diffusion coefficient (ADC) of a primary lesion correlates with local failure in primary head-and-neck squamous cell carcinoma (HNSCC) treated with chemoradiotherapy or radiotherapy. Methods and Materials: We retrospectively studied 38 patients with primary HNSCC (12 oropharynx, 20 hypopharynx, 4 larynx, 2 oral cavity) treated with chemoradiotherapy or radiotherapy with radiation dose to gross tumor volume equal to or over 60 Gy and who underwent pretreatment magnetic resonance imaging, including diffusion-weighted imaging. Ten patients developed local failure during follow-up periods of 2.0 to 9.3 months, and the remaining 28 showed local control during follow-up periods of 10.5 to 31.7 months. The variables that could affect local failure (age, tumor volume, ADC, T stage, N stage, dose, treatment method, tumor location, and overall treatment time) were analyzed using logistic regression analyses for all 38 patients and for 17 patients with Stage T3 or T4 disease. Results: In univariate logistic analysis for all 38 cases, tumor volume, ADC, T stage, and treatment method showed significant (p < 0.05) associations with local failure. In multivariate analysis, ADC and T stage revealed significance (p < 0.01). In univariate logistic analysis for the 17 patients withmore » Stage T3 or T4 disease, ADC and dose showed significant (p < 0.01) associations with local failure. In multivariate analysis, ADC alone showed significance (p < 0.05). Conclusions: The results suggest that pretreatment ADC, along with T stage, is a potential indicator of local failure in HNSCC treated with chemoradiotherapy or radiotherapy.« less

Authors:
 [1]; ; ; ; ; ; ; ; ;  [1];  [2];  [3];  [1]
  1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City (Japan)
  2. Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City (Japan)
  3. Radiology Center, Kyushu University Hospital, Kyushu University, Fukuoka City (Japan)
Publication Date:
OSTI Identifier:
21587721
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 81; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2010.05.051; PII: S0360-3016(10)00795-9; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; COMBINED THERAPY; HEAD; LARYNX; MULTIVARIATE ANALYSIS; NECK; NMR IMAGING; ORAL CAVITY; RADIATION DOSES; RADIOTHERAPY; REGRESSION ANALYSIS; BODY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DOSES; MATHEMATICS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIOLOGY; RESPIRATORY SYSTEM; STATISTICS; THERAPY

Citation Formats

Hatakenaka, Masamitsu, E-mail: mhatake@radiol.med.kyushu-u.ac.jp, Nakamura, Katsumasa, Yabuuchi, Hidetake, Shioyama, Yoshiyuki, Matsuo, Yoshio, Ohnishi, Kayoko, Sunami, Shunya, Kamitani, Takeshi, Setoguchi, Taro, Yoshiura, Takashi, Nakashima, Torahiko, Nishikawa, Kei, and Honda, Hiroshi. Pretreatment Apparent Diffusion Coefficient of the Primary Lesion Correlates With Local Failure in Head-and-Neck Cancer Treated With Chemoradiotherapy or Radiotherapy. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.05.051.
Hatakenaka, Masamitsu, E-mail: mhatake@radiol.med.kyushu-u.ac.jp, Nakamura, Katsumasa, Yabuuchi, Hidetake, Shioyama, Yoshiyuki, Matsuo, Yoshio, Ohnishi, Kayoko, Sunami, Shunya, Kamitani, Takeshi, Setoguchi, Taro, Yoshiura, Takashi, Nakashima, Torahiko, Nishikawa, Kei, & Honda, Hiroshi. Pretreatment Apparent Diffusion Coefficient of the Primary Lesion Correlates With Local Failure in Head-and-Neck Cancer Treated With Chemoradiotherapy or Radiotherapy. United States. doi:10.1016/j.ijrobp.2010.05.051.
Hatakenaka, Masamitsu, E-mail: mhatake@radiol.med.kyushu-u.ac.jp, Nakamura, Katsumasa, Yabuuchi, Hidetake, Shioyama, Yoshiyuki, Matsuo, Yoshio, Ohnishi, Kayoko, Sunami, Shunya, Kamitani, Takeshi, Setoguchi, Taro, Yoshiura, Takashi, Nakashima, Torahiko, Nishikawa, Kei, and Honda, Hiroshi. Sat . "Pretreatment Apparent Diffusion Coefficient of the Primary Lesion Correlates With Local Failure in Head-and-Neck Cancer Treated With Chemoradiotherapy or Radiotherapy". United States. doi:10.1016/j.ijrobp.2010.05.051.
@article{osti_21587721,
title = {Pretreatment Apparent Diffusion Coefficient of the Primary Lesion Correlates With Local Failure in Head-and-Neck Cancer Treated With Chemoradiotherapy or Radiotherapy},
author = {Hatakenaka, Masamitsu, E-mail: mhatake@radiol.med.kyushu-u.ac.jp and Nakamura, Katsumasa and Yabuuchi, Hidetake and Shioyama, Yoshiyuki and Matsuo, Yoshio and Ohnishi, Kayoko and Sunami, Shunya and Kamitani, Takeshi and Setoguchi, Taro and Yoshiura, Takashi and Nakashima, Torahiko and Nishikawa, Kei and Honda, Hiroshi},
abstractNote = {Purpose: This study was performed to evaluate whether the apparent diffusion coefficient (ADC) of a primary lesion correlates with local failure in primary head-and-neck squamous cell carcinoma (HNSCC) treated with chemoradiotherapy or radiotherapy. Methods and Materials: We retrospectively studied 38 patients with primary HNSCC (12 oropharynx, 20 hypopharynx, 4 larynx, 2 oral cavity) treated with chemoradiotherapy or radiotherapy with radiation dose to gross tumor volume equal to or over 60 Gy and who underwent pretreatment magnetic resonance imaging, including diffusion-weighted imaging. Ten patients developed local failure during follow-up periods of 2.0 to 9.3 months, and the remaining 28 showed local control during follow-up periods of 10.5 to 31.7 months. The variables that could affect local failure (age, tumor volume, ADC, T stage, N stage, dose, treatment method, tumor location, and overall treatment time) were analyzed using logistic regression analyses for all 38 patients and for 17 patients with Stage T3 or T4 disease. Results: In univariate logistic analysis for all 38 cases, tumor volume, ADC, T stage, and treatment method showed significant (p < 0.05) associations with local failure. In multivariate analysis, ADC and T stage revealed significance (p < 0.01). In univariate logistic analysis for the 17 patients with Stage T3 or T4 disease, ADC and dose showed significant (p < 0.01) associations with local failure. In multivariate analysis, ADC alone showed significance (p < 0.05). Conclusions: The results suggest that pretreatment ADC, along with T stage, is a potential indicator of local failure in HNSCC treated with chemoradiotherapy or radiotherapy.},
doi = {10.1016/j.ijrobp.2010.05.051},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 81,
place = {United States},
year = {2011},
month = {10}
}