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Title: Daily Megavoltage Computed Tomography in Lung Cancer Radiotherapy: Correlation Between Volumetric Changes and Local Outcome

Abstract

Purpose: To assess the predictive or comparative value of volumetric changes, measured on daily megavoltage computed tomography during radiotherapy for lung cancer. Patients and Methods: We included 80 patients with locally advanced non-small-cell lung cancer treated with image-guided intensity-modulated radiotherapy. The radiotherapy was combined with concurrent chemotherapy, combined with induction chemotherapy, or given as primary treatment. Patients entered two parallel studies with moderately hypofractionated radiotherapy. Tumor volume contouring was done on the daily acquired images. A regression coefficient was derived from the volumetric changes on megavoltage computed tomography, and its predictive value was validated. Logarithmic or polynomial fits were applied to the intratreatment changes to compare the different treatment schedules radiobiologically. Results: Regardless of the treatment type, a high regression coefficient during radiotherapy predicted for a significantly prolonged cause-specific local progression free-survival (p = 0.05). Significant differences were found in the response during radiotherapy. The significant difference in volumetric treatment response between radiotherapy with concurrent chemotherapy and radiotherapy plus induction chemotherapy translated to a superior long-term local progression-free survival for concurrent chemotherapy (p = 0.03). An enhancement ratio of 1.3 was measured for the used platinum/taxane doublet in comparison with radiotherapy alone. Conclusion: Contouring on daily megavoltage computed tomography imagesmore » during radiotherapy enabled us to predict the efficacy of a given treatment. The significant differences in volumetric response between treatment strategies makes it a possible tool for future schedule comparison.« less

Authors:
 [1]; ; ; ;  [1];  [2];  [1]
  1. Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel, Brussels (Belgium)
  2. Department of Medical Oncology, Oncology Center, Universitair Ziekenhuis Brussel, Brussels (Belgium)
Publication Date:
OSTI Identifier:
21587664
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 80; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.04.002; PII: S0360-3016(10)00505-5; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; COMPUTERIZED TOMOGRAPHY; CT-GUIDED RADIOTHERAPY; LUNGS; NEOPLASMS; PLATINUM; BODY; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; MEDICINE; METALS; NUCLEAR MEDICINE; ORGANS; PLATINUM METALS; RADIOLOGY; RADIOTHERAPY; RESPIRATORY SYSTEM; THERAPY; TOMOGRAPHY; TRANSITION ELEMENTS

Citation Formats

Bral, Samuel, E-mail: samuelbral@yahoo.co.uk, De Ridder, Mark, Duchateau, Michael, Gevaert, Thierry, Engels, Benedikt, Schallier, Denis, and Storme, Guy. Daily Megavoltage Computed Tomography in Lung Cancer Radiotherapy: Correlation Between Volumetric Changes and Local Outcome. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.04.002.
Bral, Samuel, E-mail: samuelbral@yahoo.co.uk, De Ridder, Mark, Duchateau, Michael, Gevaert, Thierry, Engels, Benedikt, Schallier, Denis, & Storme, Guy. Daily Megavoltage Computed Tomography in Lung Cancer Radiotherapy: Correlation Between Volumetric Changes and Local Outcome. United States. doi:10.1016/j.ijrobp.2010.04.002.
Bral, Samuel, E-mail: samuelbral@yahoo.co.uk, De Ridder, Mark, Duchateau, Michael, Gevaert, Thierry, Engels, Benedikt, Schallier, Denis, and Storme, Guy. Mon . "Daily Megavoltage Computed Tomography in Lung Cancer Radiotherapy: Correlation Between Volumetric Changes and Local Outcome". United States. doi:10.1016/j.ijrobp.2010.04.002.
@article{osti_21587664,
title = {Daily Megavoltage Computed Tomography in Lung Cancer Radiotherapy: Correlation Between Volumetric Changes and Local Outcome},
author = {Bral, Samuel, E-mail: samuelbral@yahoo.co.uk and De Ridder, Mark and Duchateau, Michael and Gevaert, Thierry and Engels, Benedikt and Schallier, Denis and Storme, Guy},
abstractNote = {Purpose: To assess the predictive or comparative value of volumetric changes, measured on daily megavoltage computed tomography during radiotherapy for lung cancer. Patients and Methods: We included 80 patients with locally advanced non-small-cell lung cancer treated with image-guided intensity-modulated radiotherapy. The radiotherapy was combined with concurrent chemotherapy, combined with induction chemotherapy, or given as primary treatment. Patients entered two parallel studies with moderately hypofractionated radiotherapy. Tumor volume contouring was done on the daily acquired images. A regression coefficient was derived from the volumetric changes on megavoltage computed tomography, and its predictive value was validated. Logarithmic or polynomial fits were applied to the intratreatment changes to compare the different treatment schedules radiobiologically. Results: Regardless of the treatment type, a high regression coefficient during radiotherapy predicted for a significantly prolonged cause-specific local progression free-survival (p = 0.05). Significant differences were found in the response during radiotherapy. The significant difference in volumetric treatment response between radiotherapy with concurrent chemotherapy and radiotherapy plus induction chemotherapy translated to a superior long-term local progression-free survival for concurrent chemotherapy (p = 0.03). An enhancement ratio of 1.3 was measured for the used platinum/taxane doublet in comparison with radiotherapy alone. Conclusion: Contouring on daily megavoltage computed tomography images during radiotherapy enabled us to predict the efficacy of a given treatment. The significant differences in volumetric response between treatment strategies makes it a possible tool for future schedule comparison.},
doi = {10.1016/j.ijrobp.2010.04.002},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 80,
place = {United States},
year = {2011},
month = {8}
}