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Title: Stereotactic Fractionated Radiotherapy and LINAC Radiosurgery in the Treatment of Vestibular Schwannoma-Report About Both Stereotactic Methods From a Single Institution

Abstract

Purpose: To evaluate tumor control and side effects associated with radiosurgery (RS) and stereotactic fractionated radiotherapy (SFR) for vestibular schwannomas (VSs) in a group of patients treated at the same institution. Methods and Materials: Between May 1997 and June 2007, 115 consecutive cases of VS were treated in our department. The SFR group (47 patients), including larger tumors (maximum diameter >1.5 cm), received a total dose of 54 Gy at 1.8 Gy per fraction. The RS group (68 patients, maximum diameter <1.5 cm) received a total dose of 12 Gy at the 100% isodose. Evaluation included serial imaging tests (magnetic resonance imaging) and neurologic and functional hearing examinations. Results: The tumor control rate was 97.9% in the SFR group for a mean follow-up time of 32.1 months and 98.5% in the RS group for a mean follow-up time of 30.1 months. Hearing function was preserved after RS in 85% of the patients and after SFR in 79%. Facial and trigeminal nerve function remained mostly unaffected after SFR. After RS, new trigeminal neuropathy occurred in 9 of 68 patients (13%). Conclusions: A high tumor control rate and low number of side effects are registered after SFR and RS of VS. Thesemore » results confirm that considering tumor diameter, both RS and SFR are good treatment modalities for VS.« less

Authors:
 [1];  [2]; ; ;  [1];  [3];  [4];  [5];  [1];  [6]
  1. Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technische Universitaet Muenchen, Munich (Germany)
  2. Hals-Nasen-Ohrenklinik und Poliklinik, Klinikum rechts der Isar der Technische Universitaet Muenchen, Munich (Germany)
  3. Neurochirurgische Klinik, Krankenhaus Bogenhausen, Muenchen, Munich (Germany)
  4. Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technische Universitaet Muenchen, Munich (Germany)
  5. Neurochirurgische Klinik und Poliklinik-Grosshadern, Muenchen, Munich (Germany)
  6. Klinik fuer Strahlenheilkunde, Universitaet Freiburg, Freiburg (Germany)
Publication Date:
OSTI Identifier:
21587661
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 80; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.04.057; PII: S0360-3016(10)00671-1; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; NMR IMAGING; RADIATION DOSES; RADIOTHERAPY; SURGERY; DIAGNOSTIC TECHNIQUES; DISEASES; DOSES; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; THERAPY

Citation Formats

Kopp, Christine, E-mail: Christine.Kopp@lrz.tu-muenchen.de, Fauser, Claudius, Mueller, Axel, Astner, Sabrina T., Jacob, Vesna, Lumenta, Christianto, Meyer, Bernhard, Tonn, Joerg-Christian, Molls, Michael, and Grosu, Anca-Ligia. Stereotactic Fractionated Radiotherapy and LINAC Radiosurgery in the Treatment of Vestibular Schwannoma-Report About Both Stereotactic Methods From a Single Institution. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.04.057.
Kopp, Christine, E-mail: Christine.Kopp@lrz.tu-muenchen.de, Fauser, Claudius, Mueller, Axel, Astner, Sabrina T., Jacob, Vesna, Lumenta, Christianto, Meyer, Bernhard, Tonn, Joerg-Christian, Molls, Michael, & Grosu, Anca-Ligia. Stereotactic Fractionated Radiotherapy and LINAC Radiosurgery in the Treatment of Vestibular Schwannoma-Report About Both Stereotactic Methods From a Single Institution. United States. doi:10.1016/j.ijrobp.2010.04.057.
Kopp, Christine, E-mail: Christine.Kopp@lrz.tu-muenchen.de, Fauser, Claudius, Mueller, Axel, Astner, Sabrina T., Jacob, Vesna, Lumenta, Christianto, Meyer, Bernhard, Tonn, Joerg-Christian, Molls, Michael, and Grosu, Anca-Ligia. Mon . "Stereotactic Fractionated Radiotherapy and LINAC Radiosurgery in the Treatment of Vestibular Schwannoma-Report About Both Stereotactic Methods From a Single Institution". United States. doi:10.1016/j.ijrobp.2010.04.057.
@article{osti_21587661,
title = {Stereotactic Fractionated Radiotherapy and LINAC Radiosurgery in the Treatment of Vestibular Schwannoma-Report About Both Stereotactic Methods From a Single Institution},
author = {Kopp, Christine, E-mail: Christine.Kopp@lrz.tu-muenchen.de and Fauser, Claudius and Mueller, Axel and Astner, Sabrina T. and Jacob, Vesna and Lumenta, Christianto and Meyer, Bernhard and Tonn, Joerg-Christian and Molls, Michael and Grosu, Anca-Ligia},
abstractNote = {Purpose: To evaluate tumor control and side effects associated with radiosurgery (RS) and stereotactic fractionated radiotherapy (SFR) for vestibular schwannomas (VSs) in a group of patients treated at the same institution. Methods and Materials: Between May 1997 and June 2007, 115 consecutive cases of VS were treated in our department. The SFR group (47 patients), including larger tumors (maximum diameter >1.5 cm), received a total dose of 54 Gy at 1.8 Gy per fraction. The RS group (68 patients, maximum diameter <1.5 cm) received a total dose of 12 Gy at the 100% isodose. Evaluation included serial imaging tests (magnetic resonance imaging) and neurologic and functional hearing examinations. Results: The tumor control rate was 97.9% in the SFR group for a mean follow-up time of 32.1 months and 98.5% in the RS group for a mean follow-up time of 30.1 months. Hearing function was preserved after RS in 85% of the patients and after SFR in 79%. Facial and trigeminal nerve function remained mostly unaffected after SFR. After RS, new trigeminal neuropathy occurred in 9 of 68 patients (13%). Conclusions: A high tumor control rate and low number of side effects are registered after SFR and RS of VS. These results confirm that considering tumor diameter, both RS and SFR are good treatment modalities for VS.},
doi = {10.1016/j.ijrobp.2010.04.057},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 80,
place = {United States},
year = {2011},
month = {8}
}