skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Comparison of Treatment Outcome Between Breast-Conservation Surgery With Radiation and Total Mastectomy Without Radiation in Patients With One to Three Positive Axillary Lymph Nodes

Abstract

Purpose: To test the difference in treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation, to evaluate the benefits of adjuvant radiotherapy in patients with one to three positive axillary lymph nodes. Methods and Materials: Using the Severance Hospital Breast Cancer Registry, we divided the study population of T1, T2 and one to three axillary node-positive patients into two groups: breast-conservation surgery with radiation (BCS/RT) and total mastectomy without radiation (TM/no-RT). Data related to locoregional recurrence, distant recurrence, and death were collected, and survival rates were calculated. Results: The study population consisted of 125 patients treated with BCS/RT and 365 patients treated with TM/no-RT. With a median follow-up of 68.4 months, the 10-year locoregional recurrence-free survival rate with BCS/RT and TM/no-RT was 90.5% and 79.2%, respectively (p = 0.056). The 10-year distant recurrence-free survival rate was 78.8% for patients treated with BCS/RT vs. 68.0% for those treated with TM/no-RT (p = 0.012). The 10-years overall survival rate for patients treated with BCT/RT and TM/no-RT was 87.5% and 73.9%, respectively (p = 0.035). After multivariate analysis, patients treated with BCT/RT had better distant recurrence-free survival (hazard ratio [HR], 0.527; 95% confidence interval [CI], 0.297-0.934; p = 0.028), withmore » improving locoregional recurrence-free survival (HR, 0.491; 95% CI, 0.231-1.041; p = 0.064) and overall survival trend (HR, 0.544; 95% CI, 0.277-1.067; p = 0.076). Conclusions: This study provides additional evidence that adjuvant radiation substantially reduces local recurrence, distant recurrence, and mortality for patients with one to three involved nodes.« less

Authors:
; ;  [1]; ;  [2];  [1];  [3]
  1. Department of Surgery, Yonsei University College of Medicine, Seoul (Korea, Republic of)
  2. Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of)
  3. (Korea, Republic of)
Publication Date:
OSTI Identifier:
21587651
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 80; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.04.051; PII: S0360-3016(10)00664-4; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HAZARDS; LYMPH NODES; MAMMARY GLANDS; MORTALITY; MULTIVARIATE ANALYSIS; NEOPLASMS; RADIOTHERAPY; SURGERY; BODY; DISEASES; GLANDS; LYMPHATIC SYSTEM; MATHEMATICS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; STATISTICS; THERAPY

Citation Formats

Kim, Seung Il, Park, Seho, Park, Hyung Seok, Kim, Yong Bae, Suh, Chang Ok, Park, Byeong-Woo, E-mail: bwpark@yuhs.ac, and Brain Korea 21 Project, Yonsei University College of Medicine, Seoul. Comparison of Treatment Outcome Between Breast-Conservation Surgery With Radiation and Total Mastectomy Without Radiation in Patients With One to Three Positive Axillary Lymph Nodes. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.04.051.
Kim, Seung Il, Park, Seho, Park, Hyung Seok, Kim, Yong Bae, Suh, Chang Ok, Park, Byeong-Woo, E-mail: bwpark@yuhs.ac, & Brain Korea 21 Project, Yonsei University College of Medicine, Seoul. Comparison of Treatment Outcome Between Breast-Conservation Surgery With Radiation and Total Mastectomy Without Radiation in Patients With One to Three Positive Axillary Lymph Nodes. United States. doi:10.1016/j.ijrobp.2010.04.051.
Kim, Seung Il, Park, Seho, Park, Hyung Seok, Kim, Yong Bae, Suh, Chang Ok, Park, Byeong-Woo, E-mail: bwpark@yuhs.ac, and Brain Korea 21 Project, Yonsei University College of Medicine, Seoul. Mon . "Comparison of Treatment Outcome Between Breast-Conservation Surgery With Radiation and Total Mastectomy Without Radiation in Patients With One to Three Positive Axillary Lymph Nodes". United States. doi:10.1016/j.ijrobp.2010.04.051.
@article{osti_21587651,
title = {Comparison of Treatment Outcome Between Breast-Conservation Surgery With Radiation and Total Mastectomy Without Radiation in Patients With One to Three Positive Axillary Lymph Nodes},
author = {Kim, Seung Il and Park, Seho and Park, Hyung Seok and Kim, Yong Bae and Suh, Chang Ok and Park, Byeong-Woo, E-mail: bwpark@yuhs.ac and Brain Korea 21 Project, Yonsei University College of Medicine, Seoul},
abstractNote = {Purpose: To test the difference in treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation, to evaluate the benefits of adjuvant radiotherapy in patients with one to three positive axillary lymph nodes. Methods and Materials: Using the Severance Hospital Breast Cancer Registry, we divided the study population of T1, T2 and one to three axillary node-positive patients into two groups: breast-conservation surgery with radiation (BCS/RT) and total mastectomy without radiation (TM/no-RT). Data related to locoregional recurrence, distant recurrence, and death were collected, and survival rates were calculated. Results: The study population consisted of 125 patients treated with BCS/RT and 365 patients treated with TM/no-RT. With a median follow-up of 68.4 months, the 10-year locoregional recurrence-free survival rate with BCS/RT and TM/no-RT was 90.5% and 79.2%, respectively (p = 0.056). The 10-year distant recurrence-free survival rate was 78.8% for patients treated with BCS/RT vs. 68.0% for those treated with TM/no-RT (p = 0.012). The 10-years overall survival rate for patients treated with BCT/RT and TM/no-RT was 87.5% and 73.9%, respectively (p = 0.035). After multivariate analysis, patients treated with BCT/RT had better distant recurrence-free survival (hazard ratio [HR], 0.527; 95% confidence interval [CI], 0.297-0.934; p = 0.028), with improving locoregional recurrence-free survival (HR, 0.491; 95% CI, 0.231-1.041; p = 0.064) and overall survival trend (HR, 0.544; 95% CI, 0.277-1.067; p = 0.076). Conclusions: This study provides additional evidence that adjuvant radiation substantially reduces local recurrence, distant recurrence, and mortality for patients with one to three involved nodes.},
doi = {10.1016/j.ijrobp.2010.04.051},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 80,
place = {United States},
year = {2011},
month = {8}
}