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Title: Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non-Small-Cell Lung Cancer and Radiation Pneumonitis

Abstract

Purpose: To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials: In 88 consecutive patients, {sup 18}F-FDG-positron emission tomography was performed at a median of 70 days after completion of RT. Patients received 60 Gy in 30 fractions, and all but 15 had concurrent platinum-based chemotherapy. RT-induced pulmonary inflammatory changes occurring within the radiation treatment volume were scored, using a visual (0 to 3) radiotoxicity grading scale, by an observer blinded to the presence or absence of clinical radiation pneumonitis. Radiation pneumonitis was retrospectively graded using the Radiation Therapy Oncology Group (RTOG) scale by an observer blinded to the PET radiotoxicity score. Results: There was a significant association between the worst RTOG pneumonitis grade occurring at any time after RT and the positron emission tomograph (PET) radiotoxicity grade (one-sided p = 0.033). The worst RTOG pneumonitis grade occurring after the PET scan was also associated with the PET radiotoxicity grade (one-sided p = 0.035). For every one-level increase in the PET toxicity scale, the risk of a higher RTOG radiation pneumonitis score increased by approximately 40%. The PET radiotoxicity score showed no significantmore » correlation with the duration of radiation pneumonitis. Conclusions: The intensity of FDG uptake in pulmonary tissue after RT determined using a simple visual scoring system showed significant correlation with the presence and severity of radiation pneumonitis. {sup 18}F-FDG-PET may be useful in the prediction, diagnosis and therapeutic monitoring of radiation pneumonitis.« less

Authors:
 [1];  [2];  [3];  [4];  [3];  [1];  [3]
  1. Department of Radiation Oncology, Peter MacCallum Cancer Institute, Melbourne (Australia)
  2. Department of Radiation Oncology, Affiliated Hospital of NingXia Medical University, YinChuan, NingXia (China)
  3. Department of Diagnostic Imaging, Peter MacCallum Cancer Institute, Melbourne (Australia)
  4. Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Institute, Melbourne (Australia)
Publication Date:
OSTI Identifier:
21587637
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 80; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.04.021; PII: S0360-3016(10)00596-1; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; FLUORINE 18; FLUORODEOXYGLUCOSE; HAZARDS; INFLAMMATION; LUNGS; NEOPLASMS; PLATINUM; PNEUMONITIS; POSITRON COMPUTED TOMOGRAPHY; POSITRONS; RADIOTHERAPY; ANTILEPTONS; ANTIMATTER; ANTIMETABOLITES; ANTIPARTICLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELEMENTARY PARTICLES; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; FERMIONS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEPTONS; LIGHT NUCLEI; MATTER; MEDICINE; METALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; PATHOLOGICAL CHANGES; PLATINUM METALS; RADIOISOTOPES; RADIOLOGY; RESPIRATORY SYSTEM; SYMPTOMS; THERAPY; TOMOGRAPHY; TRANSITION ELEMENTS

Citation Formats

Mac Manus, Michael P., E-mail: michael.macmanus@petermac.org, Ding Zhe, Hogg, Annette, Herschtal, Alan, Binns, David, Ball, David L., and Hicks, Rodney J.. Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non-Small-Cell Lung Cancer and Radiation Pneumonitis. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.04.021.
Mac Manus, Michael P., E-mail: michael.macmanus@petermac.org, Ding Zhe, Hogg, Annette, Herschtal, Alan, Binns, David, Ball, David L., & Hicks, Rodney J.. Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non-Small-Cell Lung Cancer and Radiation Pneumonitis. United States. doi:10.1016/j.ijrobp.2010.04.021.
Mac Manus, Michael P., E-mail: michael.macmanus@petermac.org, Ding Zhe, Hogg, Annette, Herschtal, Alan, Binns, David, Ball, David L., and Hicks, Rodney J.. Mon . "Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non-Small-Cell Lung Cancer and Radiation Pneumonitis". United States. doi:10.1016/j.ijrobp.2010.04.021.
@article{osti_21587637,
title = {Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non-Small-Cell Lung Cancer and Radiation Pneumonitis},
author = {Mac Manus, Michael P., E-mail: michael.macmanus@petermac.org and Ding Zhe and Hogg, Annette and Herschtal, Alan and Binns, David and Ball, David L. and Hicks, Rodney J.},
abstractNote = {Purpose: To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials: In 88 consecutive patients, {sup 18}F-FDG-positron emission tomography was performed at a median of 70 days after completion of RT. Patients received 60 Gy in 30 fractions, and all but 15 had concurrent platinum-based chemotherapy. RT-induced pulmonary inflammatory changes occurring within the radiation treatment volume were scored, using a visual (0 to 3) radiotoxicity grading scale, by an observer blinded to the presence or absence of clinical radiation pneumonitis. Radiation pneumonitis was retrospectively graded using the Radiation Therapy Oncology Group (RTOG) scale by an observer blinded to the PET radiotoxicity score. Results: There was a significant association between the worst RTOG pneumonitis grade occurring at any time after RT and the positron emission tomograph (PET) radiotoxicity grade (one-sided p = 0.033). The worst RTOG pneumonitis grade occurring after the PET scan was also associated with the PET radiotoxicity grade (one-sided p = 0.035). For every one-level increase in the PET toxicity scale, the risk of a higher RTOG radiation pneumonitis score increased by approximately 40%. The PET radiotoxicity score showed no significant correlation with the duration of radiation pneumonitis. Conclusions: The intensity of FDG uptake in pulmonary tissue after RT determined using a simple visual scoring system showed significant correlation with the presence and severity of radiation pneumonitis. {sup 18}F-FDG-PET may be useful in the prediction, diagnosis and therapeutic monitoring of radiation pneumonitis.},
doi = {10.1016/j.ijrobp.2010.04.021},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 80,
place = {United States},
year = {2011},
month = {8}
}