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Title: Seed-mediated synthesis, properties and application of {gamma}-Fe{sub 2}O{sub 3}-CdSe magnetic quantum dots

Abstract

Seed-mediated growth of fluorescent CdSe quantum dots (QDs) around {gamma}-Fe{sub 2}O{sub 3} magnetic cores was performed at high temperature (300 deg. C) in the presence of organic surfactants. Bi-functional magnetic quantum dots (MQDs) with tunable emission properties were successfully prepared. The as-synthesized MQDs were characterized by high-resolution transmission electron microscopy (HRTEM) and dynamic light scattering (DLS), which confirmed the assembly of heterodimers. When a longer growth period was employed, a homogeneous dispersion of QDs around a magnetic nanoparticle was obtained. The magnetic properties of these nanocomposites were examined. The MQDs were superparamagnetic with a saturation magnetization of 0.40 emu/g and a coercivity of 138 Oe at 5 K. To demonstrate their potential application in bio-labeling, these MQDs were coated with a thin silica shell, and functionalized with a polyethylene glycol (PEG) derivative. The functionalized MQDs were effectively used for the labeling of live cell membranes of 4T1 mouse breast cancer cells and HepG2 human liver cancer cells. - Graphical abstract: (a) HRTEM image of oleic acid capped MPs. The size of MPs ranges from 8 to 10 nm. (b) XRD pattern of {gamma}-Fe{sub 2}O{sub 3} MPs. Highlights: > The fabrication of MQDs through a seed-mediated approach has been demonstrated. >more » The formation and assembly of these bi-functional nanocomposites have been elucidated. > The MQDs exhibit superparamagnetism and tunable emissions characteristic of the components. > MQDs with thin silica coating were successfully employed in the labeling of cancer cell membranes.« less

Authors:
; ; ; ;  [1]; ;  [2];  [3]
  1. Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669 (Singapore)
  2. Groupe de Physique des Materiaux, UMR 6634 CNRS, Universite de Rouen, Site Universitaire du Madrillet, Avenue de l'Universite, BP 12 76801 Saint Etienne du Rouvray Cedex (France)
  3. Department of Physics, Villanova University, Villanova, PA 19085 (United States)
Publication Date:
OSTI Identifier:
21580175
Resource Type:
Journal Article
Journal Name:
Journal of Solid State Chemistry
Additional Journal Information:
Journal Volume: 184; Journal Issue: 8; Other Information: DOI: 10.1016/j.jssc.2011.05.043; PII: S0022-4596(11)00292-1; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0022-4596
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CADMIUM SELENIDES; CELL MEMBRANES; COERCIVE FORCE; COMPOSITE MATERIALS; FERRITES; FLUORESCENCE; IRON OXIDES; LIGHT SCATTERING; MAGNETIC CORES; MAGNETIC PROPERTIES; MAMMARY GLANDS; NEOPLASMS; OLEIC ACID; POLYETHYLENE GLYCOLS; QUANTUM DOTS; SUPERPARAMAGNETISM; SYNTHESIS; TEMPERATURE RANGE 0400-1000 K; TRANSMISSION ELECTRON MICROSCOPY; X-RAY DIFFRACTION; ALCOHOLS; BODY; CADMIUM COMPOUNDS; CARBOXYLIC ACIDS; CELL CONSTITUENTS; CHALCOGENIDES; COHERENT SCATTERING; DIFFRACTION; DISEASES; ELECTRON MICROSCOPY; EMISSION; FERRIMAGNETIC MATERIALS; GLANDS; GLYCOLS; HYDROXY COMPOUNDS; IRON COMPOUNDS; LUMINESCENCE; MAGNETIC MATERIALS; MAGNETIC STORAGE DEVICES; MAGNETISM; MATERIALS; MEMBRANES; MEMORY DEVICES; MICROSCOPY; MONOCARBOXYLIC ACIDS; NANOSTRUCTURES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PHOTON EMISSION; PHYSICAL PROPERTIES; POLYMERS; SCATTERING; SELENIDES; SELENIUM COMPOUNDS; TEMPERATURE RANGE; TRANSITION ELEMENT COMPOUNDS

Citation Formats

Lin, Alex W.H., Ang, Chung Yen, Patra, Pranab K, Yu, Han, Hongwei, Gu, Le Breton, Jean-Marie, E-mail: jean-marie.lebreton@univ-rouen.fr, Juraszek, Jean, Chiron, Hubert, Papaefthymiou, Georgia C, Tamil Selvan, Subramanian, E-mail: subramaniant@imre.a-star.edu.sg, and Ying, Jackie Y., E-mail: jyying@ibn.a-star.edu.sg. Seed-mediated synthesis, properties and application of {gamma}-Fe{sub 2}O{sub 3}-CdSe magnetic quantum dots. United States: N. p., 2011. Web. doi:10.1016/j.jssc.2011.05.043.
Lin, Alex W.H., Ang, Chung Yen, Patra, Pranab K, Yu, Han, Hongwei, Gu, Le Breton, Jean-Marie, E-mail: jean-marie.lebreton@univ-rouen.fr, Juraszek, Jean, Chiron, Hubert, Papaefthymiou, Georgia C, Tamil Selvan, Subramanian, E-mail: subramaniant@imre.a-star.edu.sg, & Ying, Jackie Y., E-mail: jyying@ibn.a-star.edu.sg. Seed-mediated synthesis, properties and application of {gamma}-Fe{sub 2}O{sub 3}-CdSe magnetic quantum dots. United States. doi:10.1016/j.jssc.2011.05.043.
Lin, Alex W.H., Ang, Chung Yen, Patra, Pranab K, Yu, Han, Hongwei, Gu, Le Breton, Jean-Marie, E-mail: jean-marie.lebreton@univ-rouen.fr, Juraszek, Jean, Chiron, Hubert, Papaefthymiou, Georgia C, Tamil Selvan, Subramanian, E-mail: subramaniant@imre.a-star.edu.sg, and Ying, Jackie Y., E-mail: jyying@ibn.a-star.edu.sg. Mon . "Seed-mediated synthesis, properties and application of {gamma}-Fe{sub 2}O{sub 3}-CdSe magnetic quantum dots". United States. doi:10.1016/j.jssc.2011.05.043.
@article{osti_21580175,
title = {Seed-mediated synthesis, properties and application of {gamma}-Fe{sub 2}O{sub 3}-CdSe magnetic quantum dots},
author = {Lin, Alex W.H. and Ang, Chung Yen and Patra, Pranab K and Yu, Han and Hongwei, Gu and Le Breton, Jean-Marie, E-mail: jean-marie.lebreton@univ-rouen.fr and Juraszek, Jean and Chiron, Hubert and Papaefthymiou, Georgia C and Tamil Selvan, Subramanian, E-mail: subramaniant@imre.a-star.edu.sg and Ying, Jackie Y., E-mail: jyying@ibn.a-star.edu.sg},
abstractNote = {Seed-mediated growth of fluorescent CdSe quantum dots (QDs) around {gamma}-Fe{sub 2}O{sub 3} magnetic cores was performed at high temperature (300 deg. C) in the presence of organic surfactants. Bi-functional magnetic quantum dots (MQDs) with tunable emission properties were successfully prepared. The as-synthesized MQDs were characterized by high-resolution transmission electron microscopy (HRTEM) and dynamic light scattering (DLS), which confirmed the assembly of heterodimers. When a longer growth period was employed, a homogeneous dispersion of QDs around a magnetic nanoparticle was obtained. The magnetic properties of these nanocomposites were examined. The MQDs were superparamagnetic with a saturation magnetization of 0.40 emu/g and a coercivity of 138 Oe at 5 K. To demonstrate their potential application in bio-labeling, these MQDs were coated with a thin silica shell, and functionalized with a polyethylene glycol (PEG) derivative. The functionalized MQDs were effectively used for the labeling of live cell membranes of 4T1 mouse breast cancer cells and HepG2 human liver cancer cells. - Graphical abstract: (a) HRTEM image of oleic acid capped MPs. The size of MPs ranges from 8 to 10 nm. (b) XRD pattern of {gamma}-Fe{sub 2}O{sub 3} MPs. Highlights: > The fabrication of MQDs through a seed-mediated approach has been demonstrated. > The formation and assembly of these bi-functional nanocomposites have been elucidated. > The MQDs exhibit superparamagnetism and tunable emissions characteristic of the components. > MQDs with thin silica coating were successfully employed in the labeling of cancer cell membranes.},
doi = {10.1016/j.jssc.2011.05.043},
journal = {Journal of Solid State Chemistry},
issn = {0022-4596},
number = 8,
volume = 184,
place = {United States},
year = {2011},
month = {8}
}