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Title: Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study

Abstract

A series of modified SBA-15 materials were applied in drug delivery systems. The internal surface of siliceous hexagonal structure of SBA-15 was modified with different amount of (3-mercaptopropyl)trimethoxysilane (MPTMS) and oxidized in the presence of hydrogen peroxide. The sulfonated material was loaded with metoprolol tartrate or papaverine hydrochloride. Both drugs indicated strong chemical interaction with modified mesoporous surface. The characteristic of the obtained materials was performed with XRD and DRUV-vis spectrometry, themogravimetry and nitrogen adsorption (BET) measurements. The obtained results show that modification of the mesoporous materials leads towards significant decrease of the drug delivery rate. - Graphical abstract: XRD and DSC of the -SO{sub 3}H modified SBA-15 loaded with metoprolol. Highlights: > Modification of SBA-15 internal channels with SO{sub 3}H groups. > Adsorption of metoprolol and papaverine on modified SBA-15. > Uniform and homogeneous distribution of the drugs inside the mesoporous structure of SBA-15. > Release of the supported drugs.

Authors:
 [1];  [1]
  1. Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznan (Poland)
Publication Date:
OSTI Identifier:
21580154
Resource Type:
Journal Article
Journal Name:
Journal of Solid State Chemistry
Additional Journal Information:
Journal Volume: 184; Journal Issue: 7; Other Information: DOI: 10.1016/j.jssc.2011.05.015; PII: S0022-4596(11)00264-7; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0022-4596
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ADSORPTION; CALORIMETRY; DRUGS; HYDROGEN PEROXIDE; INTERACTIONS; MATERIALS; NANOSTRUCTURES; NITROGEN; SPECTROSCOPY; SURFACES; X-RAY DIFFRACTION; COHERENT SCATTERING; DIFFRACTION; ELEMENTS; HYDROGEN COMPOUNDS; NONMETALS; OXYGEN COMPOUNDS; PEROXIDES; SCATTERING; SORPTION

Citation Formats

Moritz, MichaL, and Laniecki, Marek, E-mail: laniecki@amu.edu.pl. Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study. United States: N. p., 2011. Web. doi:10.1016/j.jssc.2011.05.015.
Moritz, MichaL, & Laniecki, Marek, E-mail: laniecki@amu.edu.pl. Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study. United States. doi:10.1016/j.jssc.2011.05.015.
Moritz, MichaL, and Laniecki, Marek, E-mail: laniecki@amu.edu.pl. Fri . "Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study". United States. doi:10.1016/j.jssc.2011.05.015.
@article{osti_21580154,
title = {Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study},
author = {Moritz, MichaL and Laniecki, Marek, E-mail: laniecki@amu.edu.pl},
abstractNote = {A series of modified SBA-15 materials were applied in drug delivery systems. The internal surface of siliceous hexagonal structure of SBA-15 was modified with different amount of (3-mercaptopropyl)trimethoxysilane (MPTMS) and oxidized in the presence of hydrogen peroxide. The sulfonated material was loaded with metoprolol tartrate or papaverine hydrochloride. Both drugs indicated strong chemical interaction with modified mesoporous surface. The characteristic of the obtained materials was performed with XRD and DRUV-vis spectrometry, themogravimetry and nitrogen adsorption (BET) measurements. The obtained results show that modification of the mesoporous materials leads towards significant decrease of the drug delivery rate. - Graphical abstract: XRD and DSC of the -SO{sub 3}H modified SBA-15 loaded with metoprolol. Highlights: > Modification of SBA-15 internal channels with SO{sub 3}H groups. > Adsorption of metoprolol and papaverine on modified SBA-15. > Uniform and homogeneous distribution of the drugs inside the mesoporous structure of SBA-15. > Release of the supported drugs.},
doi = {10.1016/j.jssc.2011.05.015},
journal = {Journal of Solid State Chemistry},
issn = {0022-4596},
number = 7,
volume = 184,
place = {United States},
year = {2011},
month = {7}
}