Nuclear magnetic resonance study of Gd-based nanoparticles to tag boron compounds in boron neutron capture therapy

Journal Article · Fri Apr 01 00:00:00 EDT 2011 · Journal of Applied Physics

DOI:https://doi.org/10.1063/1.3556951· OSTI ID:21560096

Corti, M; Bonora, M; Borsa, F ^[1]; Bortolussi, S; Protti, N; Santoro, D; Stella, S; Altieri, S ^[2]; Zonta, C; Clerici, A M; Cansolino, L; Ferrari, C; Dionigi, P ^[3]; Porta, A; Zanoni, G; Vidari, G ^[4]

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1. Dipartimento di Fisica A.Volta, Unita CNISM e Unita INSTM, Via Bassi 6, Universita di Pavia, I-27100 Pavia (Italy)
2. Dipartimento di Fisica Nucleare e Teorica e INFN Pavia, Via Bassi 6, Universita di Pavia, I-27100 Pavia (Italy)
3. Dipartimento di Scienze Chirurgiche, Laboratorio di Chirurgia Sperimentale Botta2, Via Ferrata 9, Universita di Pavia, I-27100 Pavia (Italy)
4. Dipartimento di Chimica Organica, Via Taramelli 10, Universita di Pavia, I-27100 Pavia (Italy)

We report the investigation of new organic complexes containing a magnetic moment (Gd-based molecular nanomagnets), which can serve the double purpose of acting as boron neutron capture therapy (BNCT) agents, and at the same time act as contrast agents to detect the molecule in the tissue by a proton magnetic resonance imaging (MRI). We also explore the possibility of monitoring the concentration of the BNCT agent directly via proton and boron NMR relaxation. The absorption of {sup 10}B-enriched molecules inside tumoral liver tissues has been shown by NMR measurements and confirmed by {alpha} spectroscopy. A new molecular Gd-tagged nanomagnet and BNCT agent (GdBPA) has been synthesized and characterized measuring its relaxivity R{sub 1} between 10 kHz and 66 MHz, and its use as a contrast agent in MRI has been demonstrated. The NMR-based evidence of the absorption of GdBPA into living tumoral cells is also shown.

• OSTI ID: 21560096
• Journal Information: Journal of Applied Physics, Vol. 109, Issue 7; Conference: 55. annual conference on magnetism and magnetic materials, Atlanta, GA (United States), 14-18 Nov 2010; Other Information: DOI: 10.1063/1.3556951; (c) 2011 American Institute of Physics; ISSN 0021-8979
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
62 RADIOLOGY AND NUCLEAR MEDICINE
77 NANOSCIENCE AND NANOTECHNOLOGY
ABSORPTION
ALPHA SPECTROSCOPY
BIOPHYSICS
BORON
BORON 10
BORON COMPOUNDS
CONTRAST MEDIA
GADOLINIUM COMPOUNDS
MAGNETIC MOMENTS
MAGNETISM
MOLECULES
NANOSTRUCTURES
NEUTRON CAPTURE THERAPY
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEAR MEDICINE
PARTICLES
PROTONS
RELAXATION
BARYONS
BORON ISOTOPES
DIAGNOSTIC TECHNIQUES
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
HADRONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MEDICINE
NEUTRON THERAPY
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
PHYSICS
RADIOLOGY
RADIOTHERAPY
RARE EARTH COMPOUNDS
RESONANCE
SEMIMETALS
SORPTION
SPECTROSCOPY
STABLE ISOTOPES
THERAPY